Omega-3 pentaenoic acid compositions and methods of use
A composition and technology of eicosapentaenoic acid, applied in the direction of drug combination, active ingredient of heterocyclic compound, application, etc., can solve problems such as unmet medical needs
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Embodiment 1
[0188] Intermediates MEGAPEX E90D00EE (90% EPA ethyl ester) and MAXOMEGA DPA95FFA (≥95% DPA synthetic fatty acid made from EPA ethyl ester concentrate) converted to ethyl esters respectively by mixing and homogenizing in a ratio of 98:2 to prepare the composition of the present invention. These intermediates are prepared and sold commercially by Chemport Korea (MEGAPEX) and Equateq Ltd (MAXOMEGA) from Scotland, UK. The relative amounts of fatty acids present in the starting intermediates and the resulting novel compositions are listed in Table 1 below. The resulting novel composition comprises 89.10% EPA, 1.95% DPA, 0.19% HPA, 91.24% omega-3-pentaenoic acid, less than 0.01% DHA, 91.24% omega-3-pentaenoic acid, 93.09% of total omega-3 fatty acids, 3.15% ARA and 3.57% omega-6 fatty acids (all area %).
[0189] Table 1. The intermediate of embodiment 1 and the fatty acid composition (area %) of novel composition
[0190]
Embodiment 2
[0192] Intermediates MEGAPEX E90D00EE (90% EPA ethyl ester) and MAXOMEGA DPA95FFA (≥95% DPA synthetic fatty acid made from EPA ethyl ester concentrate) converted to ethyl esters respectively by mixing and homogenizing in a ratio of 96:4 to prepare the composition of the present invention. These intermediates are prepared and sold commercially by Chemport Korea (MEGAPEX) and Equateq Ltd (MAXOMEGA) from Scotland, UK. The relative amounts of fatty acids present in the starting intermediates and the resulting novel compositions are listed in Table 2 below. The resulting novel composition contained 87.28% EPA, 3.89% DPA, 0.18% HPA, 91.35% omega-3-pentaenoic acid, less than 0.01% DHA, 93.17% total omega-3 fatty acids, and 3.49% omega -6 fatty acids (both area %).
[0193] Table 2. The intermediate of embodiment 2 and the fatty acid composition (area %) of novel composition
[0194]
Embodiment 3
[0196] Intermediates MEGAPEX E90D00EE (90% EPA ethyl ester) and MAXOMEGA DPA95FFA (≥95% DPA synthetic fatty acid made from EPA ethyl ester concentrate) converted to ethyl esters respectively by mixing and homogenizing in a ratio of 94:6 to prepare the composition of the present invention. These intermediates are prepared and sold commercially by Chemport Korea (MEGAPEX) and Equateq Ltd (MAXOMEGA) from Scotland, UK. The relative amounts of fatty acids present in the starting intermediates and the resulting novel compositions are listed in Table 3 below. The resulting novel composition contained 85.46% EPA, 5.84% DPA, 0.18% HPA, 91.48% omega-3-pentaenoic acid, less than 0.01% DHA, 93.26% total omega-3 fatty acids, 3.02% ARA and 3.42% omega-6 fatty acids (both area %).
[0197] Table 3. The intermediate of embodiment 3 and the fatty acid composition (area %) of novel composition
[0198]
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