Sampling interface device for ionization source, mass spectrometer and liquid chromatography-mass spectrometer

Abstract

The invention provides a sample injection interface device for an ionization source, a mass spectrometer and a liquid chromatography-mass spectrometer; the sample injection interface device for an ionization source includes a liquid phase capillary, which has a liquid phase inlet; The liquid sample at the phase outlet is converted into a gas-liquid spray pipe that is transported to the ionization area between the outlet of the ion source and the ion sampling port of the mass spectrometer. There are sheath gas inlet and sheath liquid inlet; the sheath gas pipeline for delivering preset pressure sheath gas to the gas-liquid channel, which communicates with the sheath gas inlet; the sheath fluid pipeline for delivering sheath fluid to the gas-liquid channel , which communicates with the sheath liquid inlet; a heating element for heating the spray sprayed from the outlet of the gas-liquid nozzle, which is located on the side of the outlet of the gas-liquid nozzle close to the ionization region. The invention can reduce the influence of inorganic salts and weak polar organic solvents on the ionization of mass spectrometers, and expand the application range of liquid mass spectrometry.

Description

technical field [0001] The present invention relates to the technical field of detection and analysis, and more specifically, to a sample injection interface device for ionization sources. Liquid Chromatography Mass Spectrometry. Background technique [0002] Mass spectrometry is a technology that ionizes target molecules through physical and chemical means, and uses electromagnetic fields to distinguish and detect charged molecules according to their mass-to-charge ratios. This technology has the characteristics of fast analysis speed, high sensitivity and strong specificity, so it is widely used in the fields of chemistry and chemical engineering, biology and life science, medicine, pharmacy, material science, environmental protection science and so on. Liquid chromatography analysis technology, including capillary electrophoresis, is a relatively mature separation method, which has the characteristics of high separation efficiency, high sensitivity, fast speed, wide adap...

AI Technical Summary

Problems solved by technology

However, when the liquid sample contains non-volatile inorganic salts (such as inorganic buffer salts or hydrochloride, etc.), the salts will accumulate at the nozzle, destroy the integrity of the spray, and block the ion transmission channel of the mass spectrometer, and the salt and Weakly polar organic reagents in liquid samples can also produce inhibitory effects such as competitive ionization and matrix effects, which prevent effective ionization of target molecules

Therefore, the scope of application of LC-MS is limited

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