Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease

An adsorbent, oral technology, applied in the field of liver disease treatment or preventive agent, kidney disease treatment or preventive agent, can solve the problem of large economic burden on patients, and achieve the effect of excellent adsorption capacity and high efficacy

Inactive Publication Date: 2015-10-07
KUREHA KAGAKU KOGYO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since such a hemodialysis type artificial kidney uses a special device, specialized technical personnel are required for safety management.
Furthermore, since blood is taken out of the body, there is a problem that the physical, mental, and economical burdens on the patient are large, so this is not necessarily a satisfactory method.

Method used

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  • Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease
  • Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease
  • Orally administered adsorbent, therapeutic agent for renal disease, and therapeutic agent for liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129]4500 g of ion-exchanged water, 0.9 g of sodium nitrite, and 6.8 g of methylcellulose (METOLOSE) 60SH-15, manufactured by Shin-Etsu Chemical Co., Ltd., were placed in a 10 L polymerization reactor. Here, 376g of styrene, 1049g of divinylbenzene, namely 57% of divinylbenzene and 43% of ethylvinylbenzene, 75g of acrylonitrile, 8.7g of 2,2'-azobis(2, 4-dimethylvaleronitrile) and 525 g hexane as porogen. Thereafter, the inside of the system was replaced with nitrogen gas. This two-phase system was heated to 55° C. while stirring at 180 rpm, and then kept in this state for 20 hours. Then, the obtained resin was washed with water, filtered, and dried at 180° C. for 16 hours under nitrogen flow to obtain a spherical porous synthetic resin with an average particle diameter of 197 μm.

[0130] The obtained spherical porous synthetic resin was charged into a reaction tube with a porous plate, and infusible treatment was performed in a vertical tubular furnace. As non-melting tre...

Embodiment 2

[0132] The resin preparation operation of Example 1 was repeated except that 301 g of styrene, 150 g of acrylonitrile, and 180 rpm of the two-phase system were used to prepare a spherical porous synthetic resin. The obtained spherical porous synthetic resin had an average particle diameter of 193 μm.

[0133] And, in addition to using the spherical porous synthetic resin, an activation treatment was performed until the BET specific surface area became 1630m 2 / g, the operations of the non-melting treatment and the activation treatment of Example 1 were repeated to prepare surface-modified spherical activated carbon. The properties of the obtained surface-modified spherical activated carbon are shown in Table 1.

Embodiment 3

[0135] 4500 g of deionized water, 6.0 g of sodium nitrite, and 6.8 g of methylcellulose (METOLOSE) 60SH-15, manufactured by Shin-Etsu Chemical Co., Ltd., were placed in a 10 L polymerization reactor. Here, 582 g of styrene, 393 g of divinylbenzene, namely 57% of divinylbenzene and 43% of ethylvinylbenzene, 525 g of acrylonitrile and 8.7 g of 2,2'-azobis(2, 4-dimethylvaleronitrile), and 375 g of hexane as a porogen, the system was replaced with nitrogen. This two-phase system was heated to 55° C. while stirring at 150 rpm, and then kept in this state for 20 hours. Then, the obtained resin was washed with water, filtered, and dried at 180° C. for 16 hours under nitrogen flow to obtain a spherical porous synthetic resin with an average particle diameter of 171 μm.

[0136] The obtained spherical porous synthetic resin was charged into a reaction tube with a porous plate, and infusible treatment was performed in a vertical tubular furnace. As non-melting treatment, dry air is di...

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Abstract

The purpose of the present invention is to provide surface-modified spherical active carbon exhibiting excellent adsorption capacity with respect to uremic substances in the body, and particularly with respect to β-aminoisobutyric acid. Accordingly, provided is an orally administered adsorbent characterized by including surface-modified spherical active carbon which includes at least 0.5 wt% of nitrogen, and which has a specific surface area obtained using the Brunauer-Emmett-Teller (BET) method of 800-3000 m2 / g, an average particle size of 0.01-1 mm, and a total acid group content of at least 0.30 meq / g.

Description

technical field [0001] The present invention relates to an adsorbent for oral administration comprising surface-modified spherical activated carbon containing more than 0.5% by weight of nitrogen atoms. Furthermore, the present invention relates to a therapeutic or preventive agent for kidney disease and a therapeutic or preventive agent for liver disease, which contain the adsorbent for oral administration as an active ingredient. [0002] The adsorbent for oral administration according to the present invention is excellent in the ability to adsorb uremic substances in the living body, particularly amino β-isobutyrate. Background technique [0003] Patients with renal and hepatic impairments may accumulate or generate harmful toxic substances in the blood as their organs become dysfunctional. Therefore, it is easy to cause encephalopathy such as uremia and disturbance of consciousness. The number of these patients tends to increase year by year. Therefore, the development ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61K31/785A61P1/16A61P13/12A61P39/02
CPCA61K31/785A61K9/14A61K33/44B01J20/28064B01J20/28066B01J20/28004B01J20/28019B01J20/20A61P1/16A61P13/12A61P39/02
Inventor 若穗围尚志秋田恭弘园部直弘桑原三惠子
Owner KUREHA KAGAKU KOGYO KK
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