Application of vorinostat for preparation of immunomodulatory drugs

An immunomodulatory drug, the technology of vorinostat, which is applied in the field of medicine and can solve problems such as inapplicable cases

Inactive Publication Date: 2015-11-18
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, long-term application of such drugs locally or systemically can lead to many ocular or systemic complications
In addition, due to the heterogeneity of human uveitis itself, blocking a single cytokine is not suitable for all cases

Method used

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  • Application of vorinostat for preparation of immunomodulatory drugs
  • Application of vorinostat for preparation of immunomodulatory drugs
  • Application of vorinostat for preparation of immunomodulatory drugs

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Embodiment Construction

[0036] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0037] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides an application of vorinostat for preparation of immunomodulatory drugs. New properties of vorinostat are determined through a large quantity of experiments and include that vorinostat can inhibit STAT-1 and STAT-3 signal pathways, so that naive T cells are inhibited from differentiating to Th1 and Th17 lymphocytes, and IFN-gamma and IL-17 expression quantities are reduced; vorinostat can increase the number of nTreg cells of CD4<+>CD25<+>Foxp3<+>; vorinostat can inhibit expression of NF-kappa B P65, thereby inhibiting the expression quantity of TNF-alpha and relieving infiltration of macrophages; vorinostat can further increase the expression quantity of tight junction protein claudin-5, and accordingly, blood retinal barrier injury is repaired. On the basis of the properties, the novel application of vorinostat as the immunomodulatory drug is determined, the application of vorinostat used for experimental autoimmune uveitis therapeutic drugs is further determined, and the experiments prove that vorinostat has definite curative effect on experimental autoimmune uveitis, has a brand-new treatment pathway, is free of side effects and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, and further relates to the new medical application of the substance, in particular to the application of vorinostat for preparing immunomodulatory drugs. Background technique [0002] Immunomodulatory drugs generally refer to a series of drugs that can regulate the microscopic operation of the immune system. Since there are many types of diseases whose effect is the imbalance of the microscopic operating state of the immune system, the regulation of the immune system through drug intervention may be used as a therapeutic approach for different diseases. [0003] The uvea (Uvea) is the middle layer of the eyeball wall, including the iris, ciliary body and choroid, three structures rich in blood vessels and pigments. Autoimmune uveitis (Autoimmuneuveitis) is a complex group of vision-threatening diseases and is one of the leading causes of vision loss worldwide. Autoimmune uveitis can be divided...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61P37/02A61P27/02
Inventor 颜华孟祥达方思捷刘媛媛郑芳张竹红
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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