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A kind of Xuesaitong soft capsule and its preparation method and detection method

A detection method and soft capsule technology, which can be used in capsule delivery, measuring devices, and pharmaceutical formulations, can solve problems affecting the accuracy of the detection method, large error range, and inaccurate dosage, so as to achieve appropriate hardness, reduce errors, and improve quality. good stability effect

Active Publication Date: 2018-07-20
KUNMING SHENGHUO PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional preparations do not contain vegetable oil, and the existing method for the determination of notoginseng saponins can be used for product content detection. However, Xuesaitong soft capsules contain vegetable oil in the preparation content, and if the existing method for detecting total saponins of notoginseng is used, it will be due to vegetable oil Therefore, these methods are not suitable for the content determination of Xuesaitong soft capsules, and the error range is large, which will directly lead to inaccurate dosage

Method used

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  • A kind of Xuesaitong soft capsule and its preparation method and detection method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 60kg of Panax notoginseng total saponins, 8kg of beeswax, 242kg of peanut oil and 20kg of palm oil, mix them evenly, and grind to obtain the contents; then weigh 220kg of medicinal gelatin, 99kg of glycerin, 1.76kg of white pigment, 0.308kg of ethylparaben, milk Mix 1.012kg of chocolate brown and 242kg of purified water, sol, filter, and stabilize the gel to obtain capsule skins; the contents and capsule skins are placed in a pilling device for pilling, drying, ball selection, polishing, and packaging. Specifications: 0.33g per capsule, each capsule contains 60mg of Panax notoginseng saponins.

Embodiment 2

[0027] Weigh 65kg of Panax notoginseng total saponins, 10kg of beeswax, 235kg of peanut oil, and 20kg of palm oil, mix them evenly, and grind to obtain the contents; then weigh 220kg of medicinal gelatin, 99kg of glycerin, 1.76kg of white pigment, 0.308kg of ethylparaben, milk Mix 1.012kg of chocolate brown and 242kg of purified water, sol, filter, and stabilize the gel to obtain capsule skins; the contents and capsule skins are placed in a pilling device for pilling, drying, ball selection, polishing, and packaging. Specifications: 0.33g per capsule, each capsule contains 60mg of Panax notoginseng saponins.

Embodiment 3

[0029] With the above-mentioned embodiment gained product waits for inspection as test sample.

[0030] [Content Determination] The total saponins of Panax notoginseng were determined by UV-Vis spectrophotometry (Appendix VA of Chinese Pharmacopoeia 2010 Edition).

[0031] Preparation of reference substance solution: Accurately weigh an appropriate amount of ginsenoside Re reference substance, add methanol to make a solution containing 1mg per 1ml.

[0032] Drawing of the standard curve: Precisely draw 0.3ml, 0.4ml, 0.5ml, 0.6ml, 0.7ml of the above solutions into 10ml volumetric flasks respectively, add methanol to dilute to the mark, shake well, precisely draw 2ml of the above-mentioned series of reference substance solutions, and place them in In a 10ml stoppered test tube, evaporate to dryness in a water bath, cool to room temperature, add 0.2ml of 5% vanillin glacial acetic acid solution, 0.8ml of perchloric acid, develop color in a 70°C water bath for 15 minutes, let cool...

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Abstract

The invention discloses Xuesaitong soft capsules, a preparation method of the Xuesaitong soft capsules, and a detecting method of the Xuesaitong soft capsules and belongs to the technical field of pharmaceutical preparation. Each soft capsule contains 330mg of content, wherein the content comprises 60mg of panax notoginseng saponins and the balance of pharmaceutic adjuvant. The panax notoginseng saponins comprise 3.0-5.0mg of notoginsenoside R1, 15.0-20.0mg of ginsenoside Rg1, 15.0-20.0mg of ginsenoside Rb1, 1.5-4.5mg of ginsenoside Re and 3.0-5.0mg of ginsenoside Rd, and the total amount of the saponins is 45-50mg. The Xuesaitong soft capsules and the preparation and detecting methods of the Xuesaitong soft capsules have the advantage that the Xuesaitong soft capsules are more stable and controllable in detecting result during detecting.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a Xuesaitong soft capsule, a preparation method and a detection method thereof. Background technique [0002] Xuesaitong soft capsule is a preparation made of Panax notoginseng saponins as the main component, which has the functions of promoting blood circulation and removing blood stasis, and dredging the meridians and collaterals. It is used in the recovery period of meridians in apoplexy due to blood stasis and closed veins syndrome. Symptoms include hemiplegia, hemiplegia, crooked mouth and tongue, strong tongue and difficulty in speaking or not speaking. Or it can be used for coronary heart disease angina pectoris caused by heart blood stasis, and symptoms include chest tightness, chest pain, palpitation, dark purple tongue or ecchymosis. [0003] Xuesaitong products use Panax notoginseng saponins as the main raw material, and are available i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/258A61K31/704A61K47/44G01N21/33G01N30/02
Inventor 方松兰锋蓝桂华
Owner KUNMING SHENGHUO PHARMA GRP
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