A flat pet system and its application

Abstract

A flat-panel PET system for in vitro cell radionuclide experiments, including a data acquisition module, which includes two sets of parallel and oppositely placed PET detection flat panels to detect gamma photons emitted by cell samples; a data processing module to obtain PET detection flat panels The energy information, position information and time information of the received gamma photons are processed to obtain the projection data; the image reconstruction module: process the projection data to obtain the reconstructed image; and the cell culture plate fixing module is used to set the cell culture plate between the two PET detectors Between the plates, the mechanical control module is used to adjust the relative positions of the cell culture plate and the two groups of PET detection plates so that the cell culture plate is located at the center of the field of view of the flat PET system. It further improves the sensitivity of PET, can detect samples with lower activity, and is more suitable for the conditions of in vitro cell experiments. It can also obtain more data, obtain a higher image signal-to-noise ratio, and improve the accuracy of quantification.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to a positron emission tomography imaging system. Background technique [0002] In the research of new drug development, efficacy evaluation, etc., the in vitro nuclide uptake experiment of cells is usually carried out before in vivo animal experiments, and the results of in vitro cell experiments will be directly used as the basis for animal experiments. Therefore, in vitro cell experiments Whether accurate experimental data can be obtained is particularly important for animal experiments. [0003] Positron-labeled radionuclide tracers are widely used in in vitro nuclide uptake experiments in cells. By obtaining cells that are exposed to radionuclides (such as: 11 C (a carbon nuclide with a mass number of 11), 18 The F (fluorine nuclide with a mass number of 18)) labeled compound, that is, the uptake of the tracer, can reflect the physiological information of the cell. The radionucl...

AI Technical Summary

Problems solved by technology

But the method that utilizes gamma radioimmunocounter to carry out measurement often has the following deficiencies: (1) when measuring the residual amount of imaging agent in the cell, need to digest respectively to the cell in each hole in the cell orifice plate, wash, Gamma counts were collected and measured with a gamma radioimmunocounter to obtain gamma counts in each well

(3) Dynamic measurement cannot be performed; (4) Since the cell experiment is measured by a gamma radioimmunometer, and the subsequent small animal experiments in the body are measured by small animal PET, the results of the experiment cannot be directly measured. To be transformed, a series of theoretical analysis is required to realize the transformation from the results of in vitro experiments to the results of in vivo experiments

Therefore, the sensitivity of PET dedicated to humans or small animals cannot fully adapt to in vitro cell experiments. Due to the lack of sensitivity, when direct application of PET dedicated to humans or small animals for in vitro cell experiments, the quality of the final imaging cannot effectively meet the requirements. experimental needs

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