Maca chewable double layer tablet and preparation method

A chewable tablet, double-layer technology, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of obesity, difficult to mix taste, and inconvenient for users to carry and take. , to achieve the effect of fast absorption, improve self-immunity, and improve compliance

Active Publication Date: 2018-05-08
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, it is mentioned in some literatures that maca is prepared into compound candy products, although the bitterness and pungent taste of maca are covered, but excessive intake will bring negative effects such as obesity
And some simple processing, such as making it into maca wine, pasta, biscuits or drinks, is not convenient for users to carry and take
There are also literatures mentioning that the flavoring agent is mixed with maca powder to make tablets, but due to its special taste, it is difficult to prepare a taste easily acceptable to consumers

Method used

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  • Maca chewable double layer tablet and preparation method
  • Maca chewable double layer tablet and preparation method
  • Maca chewable double layer tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The sweet mannitol and sorbitol are selected as the diluent, the sucralose is used as the corrective agent, and the taste is masked with the essence. The formula is shown in Table 1.

[0061] Table 1

[0062]

[0063] Chewable tablets are prepared according to the formula in Table 1, and the preparation method is as follows:

[0064] 1. Weigh the maca powder, mannitol, and sorbitol in the prescribed amount and mix them, make wet granules with 8% PVP K30 50% ethanol solution, granulate with a 24-mesh sieve, dry at 50°C, and granulate with a 24-mesh sieve;

[0065] 2. Weigh the above granules, mix them with sucralose, essence and magnesium stearate, and press into tablets.

[0066] The flavors in the above formula are selected from strawberry flavor, lemon flavor and mixed berry flavor, and chewable tablets with three flavors are prepared respectively.

[0067] The three chewable tablets prepared in Example 1 were all sweet and then bitter during chewing, and the es...

Embodiment 2

[0069] Since the flavor of the chewable tablet prepared according to the formula in Example 1 has a light smell, it cannot cover the unique smell of maca, and during the granulation process, the material will gather into agglomerates, which is easy to sieve, so the formula needs to be adjusted. Use other flavors with strong aroma for prescription screening, and make the chewable tablets into a sweet and sour taste, and increase the concentration of ethanol as a binder to 70%. The main ingredient formula is shown in Table 2.

[0070] Table 2

[0071]

[0072] The flavors in the formula in Table 2 were selected from the following flavors: lemon flavor, mint flavor, pineapple flavor, sweet orange flavor, mint flavor plus lemon flavor, and five chewable tablets were prepared.

[0073] Chewable tablets are prepared according to the formula in Table 2, and the preparation method is as follows:

[0074] 1. Weigh the maca powder, mannitol, and sorbitol in the prescribed amount, m...

Embodiment 3

[0078] A flavoring layer with a refreshing and stimulating taste is introduced into the formula, and the flavoring layer is laminated into 6mm circular small pieces and placed in a yellow triangular drug-containing layer to make packaged chips. The package chip formula is shown in Table 3.

[0079] table 3

[0080]

[0081] Chewable tablets are prepared according to the formula in Table 3, and the preparation method is as follows:

[0082] 1. Weigh the maca powder, sorbitol, citric acid, and sucralose according to the formula of the drug-containing layer, mix them, make wet granules with 5% PVP K30 80% ethanol solution, granulate with a 24-mesh sieve, and dry at 50°C Dry, granulate with a 24-mesh sieve, add magnesium stearate, mix evenly to obtain Granule 1, and set aside;

[0083] 2. According to the formula of the flavoring layer, weigh the prescribed amount of sorbitol, citric acid, mint essence, and peach essence, mix evenly, add magnesium stearate, mix evenly, granul...

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PUM

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Abstract

The invention relates to a Maca double-layer chewable tablet, which comprises: a drug-containing layer, which contains maca powder as an active ingredient, and a diluent, a flavoring agent, a binder, a lubricant, and a flavoring layer, which contains a filler agent, flavoring agent, lubricant, and optionally, an appropriate amount of coating material is also included in the chewable tablet. The maca double-layer chewable tablet can improve the user's compliance of taking, has fast dispersion and fast absorption in the gastrointestinal tract after being chewed, and has high bioavailability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to maca double-layer chewable tablets and a preparation method thereof. Background technique [0002] Maca (Maca), also known as Maca, Peruvian ginseng, maka, maka-maca, maino, ayakchichira, ayakwillku, etc., is native to the South African Andes at an altitude of 3500-4500 meters, mainly distributed in the Puno ecological zone and the central part of Peru. Puno, a city in southeastern Peru, is a plant of the genus Lepidium of the Cruciferae family (Cruciiferae), with the scientific name Lepidium meyenii Walp. It is a plant of great nutritional and pharmacological value. [0003] The nutritional value of Maca is reflected in its rich nutritional content, including a variety of vitality nutrients, 20 kinds of essential amino acids, 16 kinds of trace elements and 8 kinds of vitamins. It is traditionally used to strengthen the body, improve self-immunity, and improve fertility ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/28A61K36/31A61K47/26A61K47/36A61P37/04A61P15/00A61P39/00A61P25/28A61P13/08A61P39/06A61P25/24A61P35/00A61P35/02A61P15/12
Inventor 谢剑炜姜庆伟王旭光林妮妮吴剑峰李朝铭
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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