Agent for modulating the dissemination of cancer cells, product comprising said agent, and use of said agent in the treatment and/or prevention of cancer

A medicament and application technology, applied in the field of medicaments regulating the spread of cancer cells, especially metastatic cancer cells, can solve problems such as low efficiency and lethality

Inactive Publication Date: 2015-12-02
塞加斯 +3
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  • Abstract
  • Description
  • Claims
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  • Agent for modulating the dissemination of cancer cells, product comprising said agent, and use of said agent in the treatment and/or prevention of cancer
  • Agent for modulating the dissemination of cancer cells, product comprising said agent, and use of said agent in the treatment and/or prevention of cancer
  • Agent for modulating the dissemination of cancer cells, product comprising said agent, and use of said agent in the treatment and/or prevention of cancer

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[0116] Materials and Methods

[0117] Purification and Characterization of Exosomes

[0118] Exosomes were isolated and purified by ultracentrifugation from the ascites of patients diagnosed with ovarian cancer at the Campustral University Hospital in Santiago. Briefly, 36 ml of ascitic fluid was centrifuged sequentially at 300 g for 10 min, 2,000 g for 20 min, and 10,000 g for 30 min in order to collect cell pellets and debris. The supernatant was filtered through a syringe filter with a pore size of 22 μm, and then centrifuged at 100,000 g for 90 min (SW80 rotor; Beckman Instruments). The collected cell mass was resuspended in 100 μL of phosphate buffered saline, aliquoted and stored at -20°C. Exosomes were quantified by solubilizing exosomal proteins and using nanodroplet and Bradford methods. The size of exosomes was analyzed by 90° angle detection and laser Doppler anemometry and anemometry (Zetasizer 3000HS Malvern Instruments), respectively, at 25°C. Exosome morphol...

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Abstract

The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent is a capture agent and/or a chemoattractant for tumor cells. The invention also relates to a product, comprising an agent for modulating metastatic kidneys tumor cell dissemination, and to a method of treatment or prevention of cancer.

Description

technical field [0001] The present invention relates to a medicament for regulating the dissemination of cancer cells, especially metastatic cancer cells, and the use of the medicament in treating or preventing cancer. The pharmaceutical composition can capture and / or attract cancer cells, especially metastatic cancer cells. The invention also relates to a method of treating or preventing cancer. Background technique [0002] The metastatic process is responsible for more than 90% of deaths caused by cancer and also represents a major challenge in oncology. Primary disease is fairly amenable to surgery and / or radiation therapy, has an acceptable response to chemotherapy, and has a favorable prognosis; however, metastatic dissemination of cancer cells is associated with contraindications to surgery and radiation therapy, especially for Chemotherapy is resistant and the prognosis is worse. [0003] In recent years, cancer cell metastasis has been identified as a stepwise pr...

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Application Information

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IPC IPC(8): A61K39/00A61K45/06A61P35/04
CPCA61K35/12A61K35/28A61K35/545A61K38/18A61K38/1808A61K38/1825A61K38/1841A61K38/19A61K38/39A61K39/0011A61K45/06A61P35/04A61P43/00
Inventor 亚历山大·德·拉·富恩特·冈萨雷斯拉斐尔·洛佩兹米格尔·阿巴尔·波萨达
Owner 塞加斯
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