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A kind of anti-biological pollution material and preparation method thereof

An anti-biological pollution, hydrophilic polymer technology, applied in the field of materials science, can solve problems such as unfavorable inhibition of protein adsorption and bacterial adhesion, and difficulty in further improving PEG surface coverage, so as to inhibit bacterial adhesion and improve surface coverage. , The effect of low protein adsorption

Active Publication Date: 2018-07-03
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The above method uses PEG grafting on the surface of the material to obtain anti-biological pollution materials that promote cell growth, but the surface coverage of PEG is difficult to further increase, which is not conducive to inhibiting protein adsorption and bacterial adhesion

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  • A kind of anti-biological pollution material and preparation method thereof
  • A kind of anti-biological pollution material and preparation method thereof
  • A kind of anti-biological pollution material and preparation method thereof

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preparation example Construction

[0065] The present invention also provides a kind of preparation method of anti-biological pollution material, comprises the following steps:

[0066] The surface of the substrate is grafted with both ends of the double-end hydrophilic polymer to obtain an anti-biological pollution material; the two end groups of the double-end hydrophilic polymer are independently selected from sulfhydryl, amino, NHS-, carboxyl or sulfonic acid groups.

[0067] The present invention provides a new idea for constructing a system for inhibiting biological pollution. The present invention adopts a simple and feasible two-end grafting modification method, and does not require complex synthesis techniques to prepare ring-shaped hydrophilic polymers on the surface of different substrates. The structural layer, that is, the anti-biofouling coating is constructed on the surface of different substrates, thereby preparing a new type of anti-biofouling material with low protein adsorption and anti-bacte...

Embodiment 1

[0096] Dissolve 10 mg of SH-PEG5000-SH (purchased from Shanghai Yanyi Biology, with a number average molecular weight of 5000) in 10 mL of PBS solution to prepare a PEG solution with a concentration of 1 mg / mL. Filtered to remove impurities and bacteria.

[0097] Set the experimental temperature at 20.0±0.1°C, first use PBS buffer to flow through the sample cell of the quartz crystal microbalance (QCM-D) to perform baseline calibration, and after the temperature and baseline are stable, the PEG is injected at a rate of 100 μL / min. The solution was passed on the surface of the QCM-D gold chip for 10 minutes, at which time the PEG molecular chains had been grafted and fixed to the chip surface through sulfur-gold bonds, and then the physically adsorbed PEG molecular chains were washed away with PBS to obtain anti-biological contamination materials.

[0098] Use VG ESCALAB MK II X-ray photoelectron spectrometer (XPS) to analyze the surface elements of the samples before and after...

Embodiment 2

[0102] Dissolve 10 mg of SH-PEG5000 (purchased from Shanghai Yanyi Biology) and SH-PEG5000-SH (purchased from Shanghai Yanyi Biology) in 10 mL of PBS solution to prepare a 1 mg / mL PEG solution.

[0103] Set the experimental temperature at 20.0±0.1°C, firstly use PBS buffer to flow through the sample cell of quartz crystal microbalance (QCM-D) for baseline calibration, and after the temperature and baseline are stable, transfer all the samples at a speed of 100 μL / min The above-mentioned PEG solution was introduced into the surface of the QCM-D gold chip for 10 min. At this time, the PEG molecular chains had been grafted and fixed to the chip surface through the sulfur-gold bond, and then the physically adsorbed PEG molecular chains were washed away with PBS respectively to obtain monothiol PEG grafts. Branched material and bis-mercapto PEG grafted material.

[0104] After the baseline was stable, the PBS solution of fibrinogen (Fib) was passed through at the same speed for 10 ...

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Abstract

The present application provides an anti-biological fouling material and a preparation method thereof. The anti-biological fouling material comprises: a substrate and a double-ended hydrophilic polymer with both ends grafted on the surface of the substrate; the double-ended hydrophilic polymer The two end groups of the polymer are independently selected from mercapto, amino, NHS-, carboxyl or sulfonic acid groups. The invention fixes both ends of the double-ended hydrophilic polymer molecular chain on the surface of the substrate at the same time, which can not only effectively improve the surface coverage of the molecular chain of the hydrophilic substance, but also effectively increase the viscoelasticity of the polymer on the surface of the substrate. In the present invention, on the one hand, the intersecting cyclic conformation surfaces can resist the insertion of proteins, especially fibrin, thereby effectively inhibiting the adsorption of proteins; on the other hand, the formed cyclic hydrophilic polymer layer can also reduce the water contact angle, It can inhibit the adhesion of bacteria and prevent the formation of biofilm. Therefore, the anti-biological pollution material provided by the present invention can achieve low protein adsorption and inhibit bacterial adhesion.

Description

technical field [0001] The invention relates to the technical field of material science, in particular to an anti-biological pollution material and a preparation method thereof. Background technique [0002] Biofouling is not only a major problem in the use of blood-contact materials, but also a key point to be paid attention to in the preparation of marine antifouling materials. When blood-contacting materials come into contact with blood, the first thing that happens is plasma protein adsorption, and then induces platelet adhesion, and irreversible platelet aggregation finally causes blood coagulation. The first occurrence of marine biological pollution is the adsorption of polysaccharides and proteins, followed by the adhesion of a large number of bacteria to form a biofilm, and finally the adhesion of a large number of green algae and shellfish, resulting in an irreversible biological pollution layer on the material. Therefore, it is particularly important to prepare an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12A61L27/28
Inventor 金晶胡宇姜伟韩媛媛
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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