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Osmotic pump controlled-release preparation containing loxoprofen sodium and preparation method thereof

An osmotic pump controlled release, loxoprofen sodium technology, applied in the directions of anti-inflammatory agents, pill delivery, non-central analgesics, etc., can solve the problems of easy side effects, poor absorption, and many times of administration. The effect of reducing gastrointestinal irritation and plasma concentration fluctuations, reducing the number of administrations, and improving patient compliance

Active Publication Date: 2018-03-20
CHANGZHOU ORFAMA PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The embodiment of the present invention provides an osmotic pump controlled-release preparation containing loxoprofen sodium to solve the problems in the prior art that loxoprofen sodium is administered frequently and poorly absorbed, and is prone to side effects

Method used

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  • Osmotic pump controlled-release preparation containing loxoprofen sodium and preparation method thereof
  • Osmotic pump controlled-release preparation containing loxoprofen sodium and preparation method thereof
  • Osmotic pump controlled-release preparation containing loxoprofen sodium and preparation method thereof

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Embodiment 1

[0030] Such as figure 2 As shown, this embodiment provides an osmotic pump controlled-release preparation containing loxoprofen sodium, which includes a tablet core 3 and a semipermeable membrane 2 with a drug release hole 1. The tablet core is made of the following raw materials by weight percentage Ingredients: Loxoprofen sodium (calculated as anhydrous) 90g, sodium chloride 13g, lactose 4g, microcrystalline cellulose 103g, ethanol 25g, magnesium stearate 3g;

[0031] The semi-permeable membrane is made of the following raw materials according to weight percentage: 40.5g of cellulose acetate, 2.59g of polyethylene glycol, 20ml of water, and 1000ml of acetone.

[0032] The preparation method of the above-mentioned osmotic pump control preparation containing loxoprofen sodium is as follows:

[0033] (1) Pass the loxoprofen sodium, filler, osmotic pressure enhancer, release regulator, and binder through a 60-mesh sieve, and mix them according to the above weight percentage, then add...

Embodiment 2

[0038] This embodiment provides an osmotic pump controlled-release preparation containing loxoprofen sodium, which includes a tablet core and a semipermeable membrane with drug release holes, and the tablet core is made of the following raw materials by weight percentage: Sodium (calculated as anhydrous) 90g, sodium chloride 70g, microcrystalline cellulose 20g, polyvinylpyrrolidone 16g, ethanol 20g, magnesium stearate 4g;

[0039] The semi-permeable membrane is made of the following raw materials according to weight percentage: 36.3 g of cellulose acetate, 3.16 g of polyethylene glycol, 20 ml of water, and 1100 ml of acetone.

[0040] The preparation method of the above-mentioned osmotic pump control preparation containing loxoprofen sodium is as follows:

[0041] (1) Pass loxoprofen sodium, fillers, osmotic pressure enhancers, release regulators, and adhesives through a 40-mesh sieve, and mix them according to the above weight percentages, then add ethanol to make a soft material, a...

Embodiment 3

[0046] This embodiment provides an osmotic pump controlled-release preparation containing loxoprofen sodium, which includes a tablet core and a semipermeable membrane with drug release holes, and the tablet core is made of the following raw materials by weight percentage: Sodium (calculated as anhydrous) 90g, sodium chloride 41g, microcrystalline cellulose 45g, polyvinylpyrrolidone 9g, hydroxypropylmethylcellulose 35g, ethanol 22g, magnesium stearate 5g;

[0047] The semi-permeable membrane is made of the following raw materials according to weight percentage: 36.0g cellulose acetate, 3.44g polyethylene glycol, 24ml water, 1200ml acetone

[0048] The preparation method of the above-mentioned osmotic pump control preparation containing loxoprofen sodium is as follows:

[0049] (1) Pass the loxoprofen sodium, filler, osmotic pressure enhancer, release regulator, and adhesive through an 80-mesh sieve, and mix them according to the above weight percentage, then add ethanol to make a soft...

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Abstract

The present invention relates to the technical field of pharmaceuticals. The embodiment of the present invention discloses an osmotic pump controlled-release preparation containing loxoprofen sodium and a preparation method thereof, wherein the osmotic pump controlled-release preparation is an osmotic pump controlled-release tablet, comprising a tablet A core and a semipermeable membrane with drug release holes, the tablet core is made of the following raw materials by weight percentage: loxoprofen sodium 35-45%, filler 10-55%, osmotic pressure accelerator 5-35% , release regulator 0-15%, binder 0-10%, lubricant 0.5-2.5%. The embodiment of the invention also discloses the preparation method of the pharmaceutical preparation. The pharmaceutical preparation provided by the invention can not only reduce the number of administrations and improve patient compliance, but also can release the drug at a constant rate, reduce gastrointestinal irritation and blood drug concentration fluctuations, and at the same time enrich the types of dosage forms that doctors can choose for clinical application. The preparation method provided by the invention is simple, efficient, highly operable, saves manpower and material resources, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an osmotic pump controlled-release preparation containing loxoprofen sodium and a preparation method thereof. Background technique [0002] Loxoprofen sodium, also known as loxoprofen sodium, loxoprofen sodium, loxoprofen sodium, is the first phenylpropionic acid precursor non-steroidal anti-inflammatory drug, the chemical name is 2-[4 -(2-oxocyclopentane-1-ylmethyl)phenyl]sodium propionate dihydrate, molecular formula is C15H17NaO3, structural formula is as follows: [0003] [0004] As a prodrug, the drug is absorbed by the digestive tract and converted into an active metabolite in the body. The active metabolite exerts analgesic, anti-inflammatory and antipyretic effects by inhibiting the synthesis of prostaglandins, and its analgesic effect is stronger than that of indole Mexin is 10 times stronger, and its anti-inflammatory and antipyretic effects are equivalent to it....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K31/192A61K47/38A61P29/00
Inventor 马建国赵昱王奕兰桑泽廷
Owner CHANGZHOU ORFAMA PHARM TECH CO LTD
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