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Antitussive and expectorant medicinal composition

A composition and drug technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems of imperfect function, low resistance to external pathogens, destruction of elastic tissue of alveolar walls, etc., and achieve good social benefits. and economic benefits, ease of quality testing, and clear efficacy components

Active Publication Date: 2018-07-31
SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, long-lasting and severe cough can affect rest, and is easy to consume physical strength, and can cause damage to the elastic tissue of the alveolar wall, and induce emphysema.
Children's viscera are delicate. On the one hand, they have low ability to resist external pathogens and are very susceptible to illness; on the other hand, due to the imperfect functions of various organs, they are extremely sensitive to drugs. very cautious
[0003] At present, although there are many kinds of drugs used to treat children's cough, there is no safe and effective specific drug. The clinical treatment is more common with chemical drugs. Most of the drugs are antipyretic, antitussive, and anti-inflammatory. However, the side effects of clinical drugs are large and dangerous. Combination with paracetamol, compound aspirin and other antipyretics and antibiotics and anti-inflammatory drugs will increase the risk of clinical drug use in children and easily produce drug resistance

Method used

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  • Antitussive and expectorant medicinal composition
  • Antitussive and expectorant medicinal composition
  • Antitussive and expectorant medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0044] Preparation Example 1 Capsule Preparation

[0045]Add one or more auxiliary materials such as starch, microcrystalline cellulose, lactose, etc. to 5 parts of betaine, 5 parts of scopoletin, 25 parts of sangxin, and 15 parts of glycyrrhizic acid in the proportion by weight, mix well, and granulate. Dried, sieved, packed into capsules, each capsule weighs 0.2-0.5g, which is the capsule of the present invention, and is taken orally to treat cough.

preparation Embodiment 2

[0046] Preparation Example 2 Tablet Preparation

[0047] 5 parts of betaine, 4 parts of scopolamine, 25 parts of sangxin, and 10 parts of glycyrrhizic acid are added by weight, and one or more of auxiliary materials such as starch, microcrystalline cellulose, and lactose are added, mixed evenly, and granulated. Dried, sieved, pressed into tablets, each tablet weighs 0.2-0.5g, which is the capsule of the present invention, and is taken orally to treat cough.

preparation Embodiment 3

[0048] Preparation Example 3 Syrup Preparation

[0049] Dissolve 1 part of betaine, 1 part of scopolamine, 30 parts of sangshin, and 15 parts of glycyrrhizic acid in water, add simple syrup, paraben, and benzoic acid, mix well and fill into colored glass bottles , namely the syrup of the present invention, for oral treatment of cough.

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Abstract

The invention discloses an antitussive and expectorant pharmaceutical composition, which contains 1-10 parts by weight of betaine, 1-10 parts of scopolamine, 10-40 parts of sangxinsu, and 10-20 parts of glycyrrhizic acid . Pharmacological experimental studies prove that the pharmaceutical composition has pharmacological activities of antitussive and expectorant, and can be used for treating diseases such as cough and pneumonia.

Description

technical field [0001] The invention relates to an antitussive and expectorant pharmaceutical composition, which has pharmacological activities of antitussive and expectorant, and can be used for treating cough, pneumonia and other diseases. Background technique [0002] Cough is a common and frequently-occurring disease, and it is also one of the most common symptoms of pediatric respiratory diseases. Especially infants often cough frequently due to repeated infections. If it is not treated in time, it is very easy to cause lower respiratory tract infections such as bronchitis and pneumonia. Affect the physical and mental health and life study of patients. Traditional Chinese medicine believes that cough is caused by exogenous six evils, internal injury of internal organs, affecting the lungs and causing vocal and phlegm symptoms. "Su Wen Pathogenesis Qi Yi Bao Ming Collection": "Cough means no phlegm but sound, lung qi injury is not clear; cough is silent but phlegm, sple...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P11/14A61P11/10A61P11/00A61K31/37A61K31/205A61K31/352A61K31/343
Inventor 谭道鹏严启新曾伟珍冯贻东佘琴陈艳萍
Owner SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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