Unlock instant, AI-driven research and patent intelligence for your innovation.

An imaging agent for pet/ct

A imaging agent and imaging agent technology, applied in the field of imaging agents, can solve the problems of false positives and achieve the effects of good targeting, excellent imaging effect, and long imaging maintenance time

Active Publication Date: 2018-08-07
GUANGDONG PHARMA UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] but 18 F-FDG is a non-tumor-specific tracer. In addition to the physiological uptake of normal tissues, some benign lesions such as inflammation, active tuberculosis, sarcoidosis, inflammatory pseudotumor, and post-radiotherapy and post-operative reactions can all be manifested as 18 High F-FDG uptake, leading to false positive results

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • An imaging agent for pet/ct
  • An imaging agent for pet/ct
  • An imaging agent for pet/ct

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] English abbreviations are as follows:

[0023] 18 F-NFP is 4-nitrobenzene-2- 18 F-propionate, DMSO is dimethylsulfoxide, DIPEA is N,N-diisopropylethylamine, FP-Arg is N -(2-fluoropropionyl)- L - arginine, 18 F-FP-Arg is N- (2- 18 F-fluoropropionyl)- L - Arginine.

[0024] A kind of imaging agent for PET / CT, described imaging agent is N -(2- 18 F-fluoropropionyl)- L - Arginine.

[0025] A preparation method for a developer for PET / CT, comprising the following steps:

[0026] 1) Preparation 18 f - Ions: radionuclides produced by cyclotron nuclear reactions 18 f - Ions, captured by the QMA column 18 f - ions, then with K 222 solution pair 18 f - Ions were eluted, the excess solvent and water in the eluent were removed, and nitrogen was blown to dry to obtain dry 18 f - ion.

[0027] 2) Under the condition of heating at 100°C for 10 minutes, the 18 f - The ions were reacted with ethyl 2-bromopropionate, potassium hydroxide, and bis(p-nitrophenyl)car...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an imaging agent for PET / CT. The imaging agent is N-(2-18F-fluoropropionyl)-L-arginine, which is composed of auxiliary group 4-nitrobenzene-2-18F-propionate and L-arginine ethyl Ester hydrochloride is prepared by amidation reaction and further hydrolysis. The imaging agent of the present invention has good targeting to lung cancer in the human lung cancer tumor-bearing nude mouse model, has relatively low uptake in the brain and muscle, and has good safety and stability; and the imaging effect is better than 18F‑FDG, long imaging duration. Therefore, the 18F-FP-Arg imaging agent of the present invention may become a better imaging agent for lung cancer and various other cancers outside the liver and kidney in the future.

Description

technical field [0001] The present invention relates to an imaging agent for PET / CT. Background technique [0002] Molecular imaging plays a huge role in tumor diagnosis, and positron emission computed tomography (PET / CT), which has emerged in recent years, is an important part of it. PET / CT has obvious advantages in tumor staging and typing, identification of benign and malignant tumors, and evaluation of curative effect. With the help of PET drugs, dynamic biological information about the energy metabolism of tumor tissues that cannot be given by CT or magnetic resonance imaging (MRI) can be provided. [0003] Currently widely used imaging agents are 18 F-fluorodeoxyglucose ( 18 F-fluorodeoxyglucose, 18 F-FDG), which enjoys the name of century molecular 18 F-FDG is currently the most widely used positron imaging agent. Glucose is an important energy substrate for the human body, and the glucose metabolism of tissues and organs reflects their functional status to a la...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/04C07C277/08C07C279/14A61K101/02
Inventor 臧林泉高思远
Owner GUANGDONG PHARMA UNIV