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Methods for treating and diagnosing systemic lupus erythematosus

A systemic technology for lupus erythematosus, applied in disease diagnosis, instrumentation, biomaterial analysis, etc., to solve problems such as organ damage

Active Publication Date: 2016-01-06
EXAGEN DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And, over time, these flares can cause irreversible organ damage

Method used

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  • Methods for treating and diagnosing systemic lupus erythematosus
  • Methods for treating and diagnosing systemic lupus erythematosus
  • Methods for treating and diagnosing systemic lupus erythematosus

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[0103] introduction

[0104] Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, which leads to autoantibody-mediated tissue damage and potentially life-threatening multiple organ failure (1). In the United States, this confounding inflammatory disease affects 161,000 to 322,000 adults, with women affected more than 9 times as many as men (2). In addition, among African Americans and Hispanics, the prevalence is higher than that of Caucasians, and the sociodemographic background predicts a poor prognosis (3). The manifestations of SLE are diverse, including erythema, arthritis, anemia, thrombocytopenia, serositis, nephritis, epilepsy, and psychosis. Because these symptoms are mixed, non-specific, and developmental, and often mimic those of other diseases, the diagnosis of SLE is complicated and can be a challenge for doctors. The diagnosis of SLE depends on a combination of the patient's medical history, current symptoms, and laboratory tests. Although the revi...

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Abstract

Methods and reagents for diagnosing, prognosing, and treating systemic lupus erythematosus (SLE) are disclosed, involving calculating an SLE risk score for a subject based on a level of each of an erythrocyte C4d (EC4d) marker, a B-cell C4d (BC4d) marker, antinuclear antibodies (ANA), anti-Smith antibodies (anti-Sm) and optional rule-out markers (SS-B / La, Scl-70, Jo-1, CENP, MCV).

Description

[0001] cross reference [0002] This application claims priority to US Provisional Patent Application Serial No. 61 / 792284 filed on March 15, 2013, which is incorporated herein by reference in its entirety. Background technique [0003] Systemic lupus erythematosus (SLE) is an autoimmune disease, which can be characterized by the production of unusual autoantibodies in the blood. These autoantibodies bind to their respective antigens to form immune complexes, which circulate and eventually deposit in tissues. This deposition of immune complexes leads to chronic inflammation and tissue damage. [0004] The exact cause of the abnormal autoimmunity of lupus is unknown. Genetics, viruses, ultraviolet light, and drugs may all play a role. Genetic factors increase the tendency to develop autoimmune diseases, and autoimmune diseases such as lupus, rheumatoid arthritis, and immune thyroid disorders are more common among relatives of lupus patients than the general population. Some scient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/564
CPCG01N33/564G01N2800/104G01N2800/50G01N2800/52G01N2800/56G01N2800/60G01N33/6854A61K39/4636G01N2333/705G01N33/6893G01N2800/24
Inventor T·德尔维厄D·巴肯
Owner EXAGEN DIAGNOSTICS
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