A preparation method of nanoparticles for heavy metal ion adsorption

A nanoparticle and heavy metal adsorption technology, which is applied in the field of nanoparticle preparation, can solve the problems of unseen preparation, and achieve the effect of simple preparation method, good effect and good stability

Active Publication Date: 2018-05-11
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no APS (artificial Pulmonary Surfactant) has been used in the preparation of heavy metal ion adsorption materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a. In the ethanol that is 2000 parts by mass, add 20 parts of dipalmitoylphosphatidylcholine, 10 parts of cholesterol, and 30 parts of phospholipids;

[0022] b. Stir magnetically at 40°C for 30 minutes until completely dissolved and no obvious lumps;

[0023] c. in the water of 2000 parts by mass, add 20 parts of acetic acid, after mixing, add 100 parts of chitosan;

[0024] d. Stir magnetically at room temperature for 12 hours until completely dissolved and no obvious particles;

[0025] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 50° C. for 60 minutes to obtain chitosan nanoparticles.

[0026] Test result: Particle size analysis is carried out after dilution, and the particle size is mainly distributed at 388nm.

Embodiment 2

[0028] a. In the ethanol that is 2000 parts by mass, add 40 parts of dipalmitoylphosphatidylcholine, 10 parts of cholesterol, and 50 parts of phospholipids;

[0029] b. Stir magnetically at 50°C for 30 minutes until completely dissolved and no obvious lumps;

[0030] c. in the water of 2000 parts by mass, add 20 parts of acetic acid, after mixing, add 100 parts of chitosan;

[0031] d. Stir magnetically at room temperature for 12 hours until completely dissolved and no obvious particles;

[0032] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 70° C. for 60 minutes to obtain chitosan nanoparticles.

[0033] Test result: Particle size analysis after dilution, the particle size is mainly distributed at 293nm.

Embodiment 3

[0035] a. In the ethanol that is 2000 parts by mass, add 80 parts of dipalmitoylphosphatidylcholine, 100 parts of cholesterol, and 10 parts of phospholipids;

[0036] b. Stir magnetically at 70°C for 50 minutes until completely dissolved and no obvious lumps;

[0037] c. in the water of 2000 parts by mass, add 40 parts of acetic acid, after mixing, add 80 parts of chitosan;

[0038] d. Stir magnetically at room temperature for 18 hours until completely dissolved and no obvious particles;

[0039] e. Add the solution obtained in b to the solution obtained in d, and keep stirring at 50° C. for 120 minutes to obtain chitosan nanoparticles.

[0040] Test result: Particle size analysis after dilution, the particle size is mainly distributed at 350nm.

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Abstract

The invention provides a method for preparing nanoparticles for adsorbing heavy metal ions. The specific steps are as follows: (1) Add a certain amount of acetic acid into water, stir to prepare a certain concentration of acetic acid solution, and weigh a certain amount of chitosan Add sugar powder into the acetic acid solution and stir for a certain period of time to obtain a uniformly dissolved chitosan acetic acid solution; (2) Weigh a certain amount of dipalmitoylphosphatidylcholine, cholesterol and phospholipids, add an appropriate amount of ethanol, stir, Obtain a completely dissolved solution; (3) Add dipalmitoylphosphatidylcholine ethanol solution to chitosan acetic acid solution, and keep stirring at a certain temperature to obtain chitosan nanoparticles. The nanoparticle adsorbing heavy metal ions prepared by the invention has many advantages such as high efficiency, low cost, and various kinds of adsorbed ions.

Description

technical field [0001] The invention relates to the field of preparation of nanometer materials, in particular to a method for preparing nanoparticle for adsorbing heavy metal ions. Background technique [0002] Chitosan is a cationic polymer, insoluble in common organic solvents, stable in lye, has strong hydrophilicity, can expand and form gel in dilute hydrochloric acid and dilute acetic acid solutions, and can be made into various A sustained-release, controlled-release dosage form (Miyazaki et al., 1988; Sawayanagi et al., 1982) has good film-forming properties, and the water-swelled chitosan film is a tough elastic material; due to the strong crystallization of chitin structure, its solubility and reactivity are poor, chitosan as a drug carrier can control drug release, prolong drug efficacy, reduce drug side effects, improve the permeability of hydrophobic drugs to cell membranes and drug stability and change the drug delivery The drug route can also greatly enhance ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/722A61K47/24A61K47/28A61P39/02A61K31/685
Inventor 何丹农朱君易帆乔宇姚燕杰刘恬
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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