Tibetan medicine ash bark bone setting cataplasm and preparation method thereof

A technology of skin bonding and ointment, which is applied in the field of medicine, can solve the problems of air bubbles affecting the quality, failure to form, and low peel strength, etc., and achieve the effect of less air bubbles, less air bubbles, and good adhesion

Inactive Publication Date: 2016-01-27
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the peeling strength (viscosity) of traditional Chinese medicine cataplasm plaster is relatively small, and auxiliary stickers are usually required to fix it. Using conventional research ideas, that is, the complete pulverization and complete extraction of the medicinal materials of Qinpi and bone grafts to prepare cataplasm plaster cannot be formed. In addition, during the preparation of Babu ointment, it is easy to produce a large number of air bubbles and affect its quality.

Method used

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  • Tibetan medicine ash bark bone setting cataplasm and preparation method thereof
  • Tibetan medicine ash bark bone setting cataplasm and preparation method thereof
  • Tibetan medicine ash bark bone setting cataplasm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0044] Experimental example 1 Study on the molding process of Babu ointment

[0045] Experiments have found that the medicinal material of Qinpi and Bone Bone is completely crushed into fine powder for feeding, or it is extracted with conventional water or ethanol, and then prepared into catarrh, but the results are not ideal, and the catarrh cannot be formed well.

[0046] 1) Prepare Pabu ointment by pulverizing the medicinal materials of Qin Pi and Bone Bone

[0047] Take the prescription medicinal materials of Qinpi bone joint, crush them and pass through a 180-mesh sieve, and select the base of the babu ointment such as gelatin, sodium hydroxymethyl cellulose, sodium polyacrylate, polyvinyl alcohol, propylene glycol, glycerin, micro-powdered silica gel, kaolin, polyethylene glycol One or several of the 400 and other matrices are prepared and mixed with pulverized prescription medicinal materials to prepare Pabu ointment. As a result, the obtained sample cannot be molded, o...

experiment example 2

[0053] Experimental example 2 Babu ointment base optimization test

[0054] On the basis of single factor investigation, the amount of water added in each step remains unchanged, the amount of azone is fixed at 20g, the amount of ethyl paraben is fixed at 2g, the extract is fixed at 10g, the fritillaria is fixed at 5g, and the keel is fixed at 5g. Intensity was used as an index, and the dosage and ratio of sodium carboxymethylcellulose, gelatin, glycerin, and sodium polyacrylate in the prescription were optimized by using an orthogonal design. 9 (3 4 ) orthogonal table to test, the factor level table is shown in Table 3

[0055] Table 1 Orthogonal design investigation factor level table

[0056]

[0057] Table 2 Babu ointment base optimization experiment results

[0058]

[0059] Table 3 Orthogonal test analysis of variance table

[0060]

[0061] According to the results of the orthogonal test, the influence order of the four factors on the peeling strength of th...

experiment example 3

[0063] Experimental example 3 optimizes the preparation process of babu ointment and reduces the generation of air bubbles

[0064] (1) Preparation of the extracts of Qinpi and Western Sichuan Feverfew: take the prescription amount of Qinpi and Western Sichuan Feverfew, add 70% ethanol to extract twice, add 70% ethanol of 10 times the amount of medicinal materials for the first time, decoct for 2 hours, the second Add 8 times the amount of 70% ethanol each time, decoct for 2 hours, combine the extracts, filter, concentrate under reduced pressure at 65°C to form a dry paste, and set aside;

[0065] (2) Take an appropriate amount of sodium carboxymethyl cellulose, an appropriate amount of sodium polyacrylate, 100g of glycerin, stir well, add 700g of water, and keep stirring in a water bath at 50°C;

[0066] (3) Take 20g of gelatin, add 300g of water, and swell in a water bath at 50°C for later use;

[0067] (4) Get 2g of ethylparaben, add dehydrated alcohol 18g to dissolve, get...

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Abstract

The invention discloses Tibetan medicine ash bark bone setting cataplasm and a preparation method thereof. Proper matrixes and the proportion thereof are screened through an experiment, part of medicinal materials are smashed and used as medicine and diluents, and the obtained cataplasm has few bubbles, is good in adhesiveness and needs no auxiliary paster.

Description

technical field [0001] The invention relates to a Tibetan medicine Qinpi Jiegu Babu ointment and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Qinpi Jiegu Capsules, recorded in the National Compilation of Chinese Patent Standards, standard number: WS-10901(ZD-0901)-2002-2011Z; the prescription composition of Qinpi Jiegu Capsules is: Qinpi 113.0g, Sichuan West Fever Chrysanthemum 80.0g, keel 57.0g, Chuan Fritillaria 80.0g; its preparation method is: take the prescription amount of Qin Pi, West Sichuan Feverfew Chrysanthemum, keel, and Chuan Fritillaria, pulverize into fine powder, mix well, pack into capsules, and get final product; Healing bone and analgesic effect, used for bruises, sprained muscles and bones, congestion, swelling and pain; clinically proven, the curative effect is remarkable. However, capsules are oral preparations. After absorption, the drug effect can only be brought into play after the blood c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/70A61K47/42A61P19/08A61P29/00
Inventor 姬涛李怀平王海苹艾洛加杨文钰
Owner SHANDONG JINHE DRUG RES DEV
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