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BET inhibition therapy for heart disease

A therapy, cardiomyopathy technology, applied in one area of ​​​​that can address high morbidity and mortality

Inactive Publication Date: 2016-02-24
DANA FARBER CANCER INST INC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although such therapies have improved survival in HF patients, the remaining morbidity and mortality remain unacceptably high

Method used

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  • BET inhibition therapy for heart disease
  • BET inhibition therapy for heart disease
  • BET inhibition therapy for heart disease

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Experimental program
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[0205] method:

[0206] Animal Models. All protocols for animal use were approved by the Institutional Animal Care and Use Committee at Case Western Reserve University and performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals. All models were performed in C57B1 / 6J mice (Jackson Laboratories) maintained in a pathogen-free facility under standard light / dark cycles with ad libitum access to food and water.

[0207] Human samples. LV samples from healthy human hearts were as described (Harley et al., 2006; Margulies et al., 2005) according to the Investigation Review Committee at the Hospital of the University of Pennsylvania, Philadelphia, PA. , Philadelphia, PA). Nucleoproteins were extracted using the NE-Per kit (Thermo Scientific #78833) according to the manufacturer's instructions. Gene expression profiles of the left ventricle obtained from non-failing and failing human hearts were curated from a publicly available dataset (Hainen-Harry et a...

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Abstract

Method for treating cardiac diseases using BET inhibitors including JQ1 are provided. Methods for treating cardiac hypertrophy, method for treating heart failure not arising from inflammation, methods for treating myocardial infarction, methods for cardio protection and methods for inhibiting restenosis are described herein. The methods involve the use of effective amounts of BET inhibitors such as JQ1.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Application No. 61 / 828,166, filed May 28, 2013, and U.S. Provisional Application No. 61 / 931,062, filed January 24, 2014, under 35 U.S.C. § 119(e), which The content of the US provisional application is incorporated herein by reference in its entirety. [0003] Federally Funded Research [0004] This invention was made with government support under National Institute of Health Grant No. R01DK093821. Accordingly, the US Government has certain rights in this invention. Background technique [0005] Heart failure (HF) is the leading cause of mortality, hospitalization and medical costs in modern society. The disease occurs when the heart is unable to maintain organ perfusion at levels sufficient to meet tissue demands, and causes fatigue, dyspnea, multiple organ dysfunction, and premature death. Existing drug therapies for individuals suffering from HF, such as beta adrenergic recept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496C07D237/04C07D413/04
CPCC07D495/14A61K31/551A61K31/5517A61P35/00A61P43/00A61P9/00A61P9/04A61P9/10A61P9/12A61K9/0034A61L31/08A61L31/16
Inventor S·M·哈尔达J·E·布拉德内尔J·D·布朗
Owner DANA FARBER CANCER INST INC