Application of sodium butyrate in preventing and curing high permeability of blood vessels and relevant diseases

Abstract

The invention discloses application of sodium butyrate in preparing medicine used for treating and restraining diseases or symptoms relevant to blood vessel permeability enhancement or postponing outbreak of the diseases or symptoms or abating the caused diseases or symptoms. The sodium butyrate can increase the expression of vascular endothelial cell adherent junction gap-associated protein p120 on the oxygen deficit condition, endothelial cell adherent junction stability is kept, and blood vessel endothelium permeability is restrained from being increased on the oxygen deficit condition; the sodium butyrate is soluble in an aqueous solution and stable in property, and not matter dry powder or the aqueous solution can be preserved at normal temperature. The sodium butyrate can be completely and directly absorbed by the intestinal tract, secondary degradation is avoided, and the price is low.

Description

technical field

[0001] The invention relates to a medical field, in particular to an application of sodium butyrate in preventing and treating vascular hyperpermeability and related diseases. Background technique

[0002] Increased vascular endothelial permeability refers to a series of pathological changes in the morphology of vascular endothelial cells or the destruction of intercellular junction complexes caused by various combined factors, resulting in increased intercellular gaps, impaired barrier function, and rapidly increased permeability. Change. Increased permeability of vascular endothelial cells allows small molecules (ions, water, nutritional molecules), macromolecules, plasma proteins, and cell components to pass through the vascular endothelium abnormally or excessively, which is an important link that causes tissue edema and inflammatory invasion. therefore. How to maintain the integrity of vascular endothelium and inhibit the increase of endothelial permea...

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