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Application of chimonanthus nitens leaf tablets in preparing medicine for inhibiting cell proliferation of breast tumor cell C127

A technique for breast tumor and cell proliferation, which is applied in the field of preparation of leaves of Prunus chinensis, can solve the problems of rough process, influence on clinical application, and many impurities.

Inactive Publication Date: 2016-03-23
济南新时代医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of the leaves of Waxweed in the preparation of drugs for inhibiting the proliferation of human breast tumor cell C127 cells, and there is no report on the use of supercritical extraction in the preparation of the leaves of Waxwax. The method of extracting volatile oil by boiling and steam distillation has a rough and backward process and many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 1500g of waxberry leaves, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 500 tablets, each weighing 0.35g.

[0025] After testing, the content of quercetin and kaempferol in the finished product is 362 μg / tablet.

Embodiment 2

[0027] Take 1500g of waxberry leaves, add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 500 tablets, each weighing 0.35g.

[0028] After testing, the content of quercetin and kaempferol in the finished product is 220 μg / tablet.

Embodiment 3

[0030] Take 1500g of waxberry leaves, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 700min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 500 tablets, each weighing 0.35g.

[0031] After testing, the content of quercetin and kaempferol in the finished product is 308 μg / tablet.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to application of chimonanthus nitens leaf tablets in preparing medicine for inhibiting cell proliferation of the breast tumor cell C127 and a preparing method of the chimonanthus nitens leaf tablets. The chimonanthus nitens leaf tablets are prepared from 1,500 g of chimonanthus nitens leaves serving as a raw material through supercritical extraction, and thus the content of quercetin and the content of kaempferol are greatly increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of waxberry leaves in preparing medicines for inhibiting the proliferation of breast tumor cell C127 cells and the preparation method of waxberry leaves. Background technique [0002] The standard number of waxberry leaves is WS-11310 (ZD-1310)-2002, which is recorded in the National Compilation of Chinese Patent Medicine Standards Internal Medicine Pulmonary System (1) Volume. It is made from 1500g of waxberry leaves as a raw material medicine, and has the effects of pungent and cooling, relieving exterior, clearing away heat and detoxifying. For wind-heat cold, fever, aversion to cold, sore throat. [0003] In the prior art, there is no report on the application of the leaves of Waxweed in the preparation of drugs for inhibiting the proliferation of human breast tumor cell C127 cells, and there is no report on the use of superc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/20A61K47/36A61P35/00
CPCA61K9/2059A61K36/185A61K2236/37
Inventor 李晶杨志华
Owner 济南新时代医药科技有限公司
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