A kind of external washing medicine for treating children's prickly heat and its preparation method

A technology for prickly heat and medicine, which is applied in the field of washing medicine for treating children's prickly heat and its preparation. It can solve the use of bitter gourd oil to remove heat rash medicine ingredients, can not meet the needs of washing medicine, and the extraction of active ingredients is not complete. problems, to achieve the effect of wide range of applicable people, low cost, and relief of itching and burning sensation

Active Publication Date: 2019-08-06
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction object is limited to the bitter melon seeds, and the active ingredients in the bitter melon fruit, which is richer in raw materials, are not extracted at the same time.
At the same time, the bitter gourd seeds need to be shelled and separated before extraction, which is a cumbersome process
In addition, this method directly performs supercritical extraction on the obtained bitter melon seed powder without pretreatment of the obtained bitter melon seed powder, and the extraction of all active ingredients in the bitter melon seed kernel is incomplete, and the extraction efficiency is low
The resulting product is only balsam pear oil, which cannot meet the needs of preparing external washing medicines for treating prickly heat in children, and the patent only mentions the use of balsam pear oil in promoting blood circulation, removing blood stasis, reducing inflammation, relieving pain, arthritis, etc. Uses of ingredients in prickly heat medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Take 1Kg of bitter gourd, wash it, cut it into 2mm thick slices, crush the melon seeds, put it in a drying oven, adjust the drying temperature to 40°C, dry it, and take it out when the water content of the bitter gourd slices is 10%.

[0033] 2. Use NaOH to prepare an aqueous solution with a pH of 9.1, dissolve the dried bitter melon slices and melon seeds, soak for 2 hours, and filter to obtain the supernatant and filter residue.

[0034] 3. Take the supernatant obtained in step 2, adjust its pH to 3.0 with hydrochloric acid, and precipitate out. The precipitate was collected by filtration, washed with water, and set aside.

[0035] 4. Take the filter residue obtained in step 2, vacuum dry it at 600Pa, 40°C, take it out when the water content of the filter residue is 10%, place it in a supercritical extraction tank, seal it, and fill it with CO 2 , Carry out the first extraction at 45MPa, 40°C. CO 2 The flow rate is 10Kg / h. After dynamic separation for 6 hours, ...

Embodiment 2

[0043] 1. Take 1Kg of bitter gourd, wash it, cut it into 2mm thick slices, crush the melon seeds, put it in a drying oven, adjust the drying temperature to 45°C, dry it, and take it out when the water content of the bitter gourd slices is 12%.

[0044] 2. Prepare an aqueous solution with a pH of 9.2 with NaOH, dissolve the dried bitter melon slices and melon seeds, soak for 1.5 hours, and filter to obtain the supernatant and filter residue.

[0045] 3. Take the supernatant obtained in step 2, adjust its pH to 2.5 with hydrochloric acid, and there is precipitation. The precipitate was collected by filtration, washed with water, and set aside.

[0046] 4. Take the filter residue obtained in step 2, vacuum dry it at 700Pa, 40°C, take it out when the water content of the filter residue is 15%, place it in a supercritical extraction tank, seal it, and fill it with CO 2 , Carry out the first extraction at 50MPa, 45°C. CO 2 The flow rate is 20Kg / h. After dynamic separation for 6 ...

Embodiment 3

[0054] 1. Take 1Kg of bitter gourd, wash it, cut it into 2mm thick slices, crush the melon seeds, put it in a drying oven, adjust the drying temperature to 50°C, dry it, and take it out when the water content of the bitter gourd slices is 10%.

[0055] 2. Use NaOH to prepare an aqueous solution with a pH of 9.2, dissolve the dried bitter melon slices and melon seeds, soak for 2 hours, and filter to obtain the supernatant and filter residue.

[0056] 3. Take the supernatant obtained in step 2, adjust its pH to 3.0 with hydrochloric acid, and precipitate out. The precipitate was collected by filtration, washed with water, and set aside.

[0057] 4. Take the filter residue obtained in step 2, vacuum-dry it at 800 Pa and 40° C., take it out when the water content of the filter residue is 13%, place it in a supercritical extraction tank, and seal it. Charge CO 2 , Carry out the first extraction at 48MPa, 50°C. CO 2 The flow rate is 25Kg / h. After dynamic separation for 6 hours,...

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Abstract

The invention relates to the field of a medicine for skin external use and specifically discloses an external washing medicine for treating children's prickly heat and a preparation method thereof. The preparation method comprises the following steps: slicing bitter gourd fruit, crushing bitter gourd seeds, and preparing bitter gourd oil and a bitter gourd mixed dry powder by an alkali treatment combined supercritical extraction method; slicing cucumber fruit, and adopting an organic solvent immersion combined supersonic extraction method to obtain a cucumber extract dry powder; and adding water and mixing the bitter gourd oil, the bitter gourd mixed dry powder and the cucumber extract dry powder in any proportion according to age and skin features of children patients so as to prepare the external washing medicine for treating children's prickly heat. Raw material resource by the method is rich, extraction efficiency is high, and there is no organic solvent residue in the product. The obtained medicine can effectively remove prickly heat and is suitable for children of different ages and with different skin features.

Description

technical field [0001] The invention relates to an external medicine for skin, in particular to an external washing medicine for treating prickly heat in children and a preparation method thereof. Background technique [0002] Prickly heat is a common skin disease in summer. Due to high external temperature and high humidity, the skin sweats are not easy to discharge in time, the sweat glands are blocked, the sweat ducts are broken, and the sweat seeps into the surrounding tissues, which leads to mild skin irritation in the dermis. Acute inflammatory reaction, prone to hyperhidrosis and skin folds such as the neck, forehead, upper chest, back, armpits, and elbow fossa. During the acute onset, dense pinpoint-sized red papules appear on the skin, with itching, stinging and burning sensations, which bring great pain to patients, especially sick children. [0003] There are many kinds of external medicines for the treatment of prickly heat in the market, mainly in the form of p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/42A61P17/00
CPCA61K9/0014A61K36/42A61K2236/17A61K2236/33A61K2236/331A61K2236/37A61K2300/00
Inventor 赵红魏巍陈怀明
Owner ANHUI UNIV OF SCI & TECH
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