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A kind of preparation method of poultry artificial bear bile powder

A technology of bear bile powder and poultry, which is applied in the field of preparation of poultry artificial bear bile powder, can solve the problems of low efficiency and cumbersome extraction methods, and achieve the effect of high efficiency and simple preparation method

Inactive Publication Date: 2018-05-18
四川新功生物科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the poultry bear bile powder usually follows the above two methods. The oxidizing agent adopts dichromate (sodium dichromate or potassium dichromate), and the reducing agent adopts metallic sodium, which not only introduces heavy metal chromium, but also has a cumbersome extraction method and low efficiency.

Method used

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  • A kind of preparation method of poultry artificial bear bile powder
  • A kind of preparation method of poultry artificial bear bile powder
  • A kind of preparation method of poultry artificial bear bile powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Get the fresh bile 1000g that just extracts from live chicken body, adopt high performance liquid chromatography to analyze its bile acid composition, such as figure 1 As shown, it was found that the bile acid component ratio in the bile was TCDCA:TCA=83:17.

[0033] At room temperature, add 15% dilute hydrochloric acid dropwise to the chicken bile to adjust the pH to 3; then slowly stir the bile at a stirring speed of 0.02m / s, during the stirring process, according to the ratio of bile to sodium peroxide mass ratio of 1:0.015, Slowly add sodium peroxide into the bile in 10 batches within 5 hours, and add a batch of sodium peroxide about every 30 minutes. After the sodium peroxide is completely added, continue to stir and react at room temperature for 9 hours to carry out the oxidation reaction; after the oxidation reaction is completed, Such as figure 2 As shown, the high-performance liquid chromatography sampling analysis shows that the bile acid composition change ...

Embodiment 2

[0038] Take 1000g of fresh bile just extracted from live ducks, analyze its bile acid components by high performance liquid chromatography, and find that the ratio of bile acid components in the bile is TCDCA:TCA=82:18.

[0039] At room temperature, add 12% dilute hydrochloric acid dropwise to the chicken bile to adjust the pH to 4; then slowly stir the bile at a stirring speed of 0.03m / s. During the stirring process, according to the ratio of bile to sodium peroxide mass ratio of 1:0.017, Slowly add sodium peroxide into the bile in 15 batches within 5 hours, and add a batch of sodium peroxide approximately every 20 minutes. After the sodium peroxide is completely added, continue to stir and react at room temperature for 10 hours to carry out the oxidation reaction; after the oxidation reaction is completed, High-efficiency liquid chromatography sampling analysis draws that after the reaction is completed, the bile acid composition changes as TCDCA: T7-ketoLCA=8.8: 91.2 (becaus...

Embodiment 3

[0044] Take 1000g of fresh bile just extracted from live goose, and analyze its bile acid components by high performance liquid chromatography, and find that the ratio of bile acid components in the bile is TCDCA:TCA=83.5:16.5.

[0045] At room temperature, add 10% dilute hydrochloric acid dropwise to the chicken bile to adjust the pH to 4; then slowly stir the bile at a stirring speed of 0.03m / s. During the stirring process, according to the ratio of bile to sodium peroxide mass ratio of 1:0.017, Slowly add sodium peroxide into the bile in 15 batches within 5 hours, and add a batch of sodium peroxide about every 20 minutes. After the sodium peroxide is completely added, continue to stir and react at room temperature for 10 hours to carry out the oxidation reaction; after the oxidation reaction is completed, High-efficiency liquid chromatography sampling analysis draws that after the reaction is completed, the bile acid composition changes as TCDCA: T7-ketoLCA=8.5: 91.5 (becaus...

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Abstract

The invention discloses a method for preparing poultry artificial bear bile powder. The method comprises the following steps: regulating pH of fresh poultry bile to be 3-4 at normal temperature with diluted hydrochloric acid; slowly adding sodium peroxide into the bile in batches under a slowly stirring state according to the mass ratio of bile to sodium peroxide being 1:(0.013-0.017), and stirring to react for 8-12 hours at normal temperature; adding metal sodium into the bile under a slowly stirring state according to the mass ratio of bile to metal sodium being 1:(0.008-0.010), and reacting for 3.5-4.5 hours at normal temperature; and regulating pH of the bile to 8-9 with diluted hydrochloric acid after the reaction is completed, drying in vacuum and grinding at 55-65 DEG C to obtain the poultry artificial bear bile powder. The preparation method is simple and has high efficiency, the final product of oxidant and reducing agent in the reacting process is sodium chloride, other heavy metal particles are not introduced, and the quality of bear bile powder cannot be influenced. The content of tauroursodeoxycholic acid in a bear bile powder product is more than 38.5 percent.

Description

technical field [0001] Embodiments of the present invention relate to the field of traditional Chinese medicine, and more specifically, embodiments of the present invention relate to a preparation method of poultry artificial bear bile powder. Background technique [0002] Bear bile referred to in traditional Chinese medicine is obtained by drying bear bile. Early bear bile was made by hunting wild bears and taking bile. Due to the high demand for bear bile and the protection of wild bears, it promoted the emergence and development of artificial bear farming. In order to distinguish it from natural bear bile, the active ingredient extracted from the bile of artificially raised bears is called bear bile powder. Although artificial bear breeding has solved the market demand for bear bile powder to a certain extent, the growth rate of market demand is higher than the yield of bear bile powder of artificial bear farming industry, resulting in a state of shortage of bear bile po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K35/57
CPCA61K31/575A61K35/57A61K2300/00
Inventor 周虹刘新宇
Owner 四川新功生物科技集团有限公司