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A method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene/apatite composite coating

A technology for composite coatings and implants, applied in coatings, metal material coating processes, prostheses, etc., can solve the problem of mechanical integrity loss, poor bonding strength of apatite film substrate, low corrosion potential of magnesium metal, high Corrosion rate and other issues, to achieve the effects of inhibiting bacterial growth, improving bone fusion speed, corrosion resistance and enhanced membrane-base bonding strength

Active Publication Date: 2018-08-28
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of low corrosion potential of magnesium metal in the prior art, high corrosion rate in body fluid environment, excessive loss of mechanical integrity and poor film-base bonding strength of apatite and easy wear and tear. , and proposed a method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene / apatite composite coating

Method used

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  • A method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene/apatite composite coating
  • A method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene/apatite composite coating
  • A method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene/apatite composite coating

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specific Embodiment approach 1

[0029] Embodiment 1: A method of preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene / apatite composite coating in this embodiment is specifically prepared according to the following steps:

[0030] Step 1. Process the magnesium metal into a cage-shaped implant. After cleaning the cage-shaped implant with 20-100ml of acetone at room temperature (room temperature is 15-25°C) for 5-20 minutes, use 20-100ml of absolute ethanol in the Ultrasonic cleaning of the cage implant at 15-25°C for 5-20 minutes;

[0031] Step 2: Use deionized water at a temperature of 15 to 25°C to clean the cage-like implant after ultrasonic cleaning with absolute ethanol for 3 to 5 minutes, then dry it at a temperature of 20 to 50°C for 10 to 20 minutes to obtain pretreatment Magnesium metal material; (this deionized water is designated by the International Organization for Standardization ISO / TC)

[0032] Step 3, carry out hydrothermal treatment to the pretr...

specific Embodiment approach 2

[0047] Embodiment 2: This embodiment differs from Embodiment 1 in that the magnesium metal described in Step 1 is pure magnesium, magnesium-aluminum alloy, magnesium-zinc alloy, magnesium-zirconium alloy, rare earth magnesium alloy or magnesium-calcium alloy. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0048] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the inside of the cage-shaped implant described in step 1 is filled with collagen, autologous granular bone, allogeneic granular bone, active factors for promoting bone fusion, or antibacterial sustained release One or more of the factors. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention provides a method for preparing a degradable magnesium cage implant with an antibacterial and anti-corrosion graphene / apatite composite coating and relates to a degradable magnesium cage implant, aiming to solve the problems that magnesium in the prior art has low corrosion potential, high corrosion rate in the body fluid environment and excessively fast mechanical integrity loss, and apatite has the defects of poor film-substrate bonding strength and easiness in wear. The method is achieved by the following steps: I, processing magnesium into a cage and removing oil, thus obtaining a cage implant; II, adding the cage implant to a reaction kettle to undergo hydrothermal reaction for surface modification, thus obtaining a hydrothermal composite coating containing graphene and apatite; and III, washing the hydrothermal composite coating by using deionized water and drying the hydrothermal composite coating, thus obtaining the degradable magnesium cage implant with the antibacterial and anti-corrosion graphene / apatite composite coating. The method is applied to the field of degradable magnesium cage implants.

Description

technical field [0001] The invention relates to a degradable magnesium cage implant, in particular to a method for preparing a degradable magnesium cage implant with an antibacterial and corrosion-resistant graphene / apatite composite coating. Background technique [0002] Bone defect is a common clinical disease, which may be caused by bone trauma, bone infection, sequestrum removal, bone tumor segment resection, etc. Bone defect repair techniques mainly include Ilizarow technique, fibula transplantation, and allograft bone therapy. Adjuvant therapy with implant devices is a common treatment method, which has the advantages of stable fixation and accurate reset. The existing implant devices for repairing bone defects generally use non-degradable or refractory alloys such as titanium, zirconium, zirconia, platinum, rhodium, niobium, surgical stainless steel, cobalt-chromium-steel, tantalum, etc., such as bone stabilizer equipment (CN 104602629 A), the cage implant of the in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C18/12A61L27/30A61L27/32A61L27/58A61L27/54
CPCA61L27/303A61L27/32A61L27/54A61L27/58A61L2300/108A61L2300/112A61L2300/404A61L2300/608A61L2420/04C23C18/1204C23C18/125
Inventor 王亚明吴云峰郭立新贾德昌周玉
Owner HARBIN INST OF TECH
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