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Acoustic Bioreactor Process

A bioreactor, reflector technology, applied in the direction of bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, microorganisms, etc., can solve problems such as limiting attraction

Active Publication Date: 2018-07-31
FLODESIGN SONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This has limited their appeal in the past

Method used

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  • Acoustic Bioreactor Process
  • Acoustic Bioreactor Process
  • Acoustic Bioreactor Process

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Embodiment Construction

[0033] The present disclosure will be better understood by reference to the following detailed description of desired embodiments and examples thereof. In the following specification and its appended claims, a number of terms are mentioned, which shall be defined to have the following meanings.

[0034] Although specific terms are used in the following description for the sake of clarity, these terms are only intended to refer to specific structures of the embodiments chosen to be shown in the figures, and are not intended to define or limit the scope of the present disclosure. In the drawings and the following description, it should be understood that like numerals refer to parts with like functions.

[0035] The singular forms "a", "an" and "the" include plural referents unless stated otherwise.

[0036] As used herein, the term "comprising" means that the indicated components are present, and the presence of other components is permitted. The term "comprising" should be i...

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Abstract

A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 61 / 845,531, filed July 12, 2013. This application is also a continuation-in-part of U.S. Patent Application Serial No. 14 / 175,766, filed February 7, 2014, which is also U.S. Patent Application Serial No. 14 / 175,766, filed September 13, 2013 Continuation in part of 14 / 026,413. The entire contents of these applications are incorporated herein by reference. Background technique [0003] Many factors have led to developments in the field of biotechnology, some of which include improvements in the equipment available for bioreactors. Improvements in equipment have enabled large-scale, low-cost production of biological derivatives, such as monoclonal antibodies and recombinant proteins. One of the key elements of the production process for new biologically-based drugs is the bioreactor and its associated auxiliary processes. [0004] A modern ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N13/00C12M1/00
CPCB06B1/0238B06B1/0648B06B2201/76C07K1/145C12M47/02C12N13/00C12P21/02
Inventor 托马斯·J·肯尼迪三世巴特·利普肯斯路易斯·玛斯斯担利·科瓦尔斯基三世克里斯·莱德尔
Owner FLODESIGN SONICS