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Dynamic assay selection and sample preparation apparatus and methods and machine-readable mediums thereof

A sample, defined technique, applied in the fields of biochemical equipment and methods, chemical instruments and methods, and microbiological determination/inspection, which can solve problems such as errors and inflexibility

Inactive Publication Date: 2016-04-20
SIEMENS HEALTHCARE DIAGNOSTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While these prior art methods operate as desired, they are often prone to error (manually) or are generally inflexible, i.e. one assay per test plate

Method used

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  • Dynamic assay selection and sample preparation apparatus and methods and machine-readable mediums thereof
  • Dynamic assay selection and sample preparation apparatus and methods and machine-readable mediums thereof
  • Dynamic assay selection and sample preparation apparatus and methods and machine-readable mediums thereof

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Embodiment Construction

[0034] Reference will now be made in detail to various embodiments of the present disclosure, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts. The Definitions section below provides definitions for some of the terms used herein.

[0035] As discussed above, due to the fixed-format preparation of the test plate, many potential test locations in the PCR plate (eg, test plate microwells) may not be used in existing automated processing methods. Alternatively, low sample preparation throughput within the laboratory may result from allowing sufficient numbers of assay orders to be placed and PCR plates to be filled more fully, but at the expense of high labor costs, increased risk of error and variability.

[0036] Accordingly, one or more embodiments of the invention provide sample preparation methods and sample preparation devices that include imp...

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Abstract

Automated methods of preparing patient samples for assays are disclosed. The methods include performing sample processing of multiple patient samples in multiple extraction wells of an extraction plate to prepare multiple eluded samples in at least some of the multiple extraction wells, and transferring, based upon an electronic plate map including multiple assay regions, one of the multiple eluded samples from a single extraction well of the multiple extraction wells into multiple test wells of the test plate, wherein each of the multiple test wells of the test plate are configured to carry out a different assay and receives a different master mix for a different assay type. Sample preparation apparatus configured to carry out the methods are described, as are other aspects

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application Serial No. 61 / 876798, entitled "Open Dynamic Assay Selection and Sample Preparation," filed September 12, 2013, the disclosure of which U.S. Provisional Application is hereby incorporated by reference in its entirety This article. technical field [0003] The present invention generally relates to methods and devices for preparing test panels for performing assays, such as by using polymerase chain reaction (PCR) tests. Background technique [0004] A wide variety of diagnostic instruments, such as clinical analyzers or immunoassay instruments, are used to analyze patient specimens (biological samples). These diagnostic instruments may use magnetic particles, one or more reagents, buffers, controls, or other additives to perform assays (such as immunoassays) to identify one or more components (such as nucleic acids) in a patient sample or Characteristics of Patient Samples....

Claims

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Application Information

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IPC IPC(8): G01N35/00
CPCG01N35/0092G01N35/028B01L3/545B01L3/5453B01L7/52B01L2300/0829B01L3/5085B01L9/56C12Q1/6806G01N35/00029G01N35/00722G01N35/0099G01N2035/00099
Inventor A.纳塔勒I.菲格罗亚
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC
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