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Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method and application thereof

A technology of traditional Chinese medicine preparations and hand, foot and mouth disease, which is applied in antiviral agents, medical formulas, medical preparations containing active ingredients, etc., can solve problems such as adverse reactions, slow treatment, and treat symptoms rather than the root cause, achieving non-toxic side effects and excellent curative effect Good, quick effect

Inactive Publication Date: 2016-05-04
陈杏芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The clinical prevention and treatment of hand, foot and mouth disease and exogenous diseases mostly adopts antiviral, cooling and symptomatic treatment. The therapeutic effect has certain limitations, the scope of application is small, and the damp heat and detoxification in the body cannot be eliminated. Onset, incomplete treatment, long-term use of western medicine, easy to damage the liver and kidneys, and even produce some serious adverse reactions, and the treatment is slow, so there are hidden dangers in the safety of clinical medication

Method used

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  • Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method and application thereof
  • Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method and application thereof
  • Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In the embodiment of the present invention, a traditional Chinese medicine preparation for treating hand, foot and mouth disease is composed of the following raw materials in parts by weight: 22 parts of Columbine, 10 parts of Radix Paeoniae Alba, and 5 parts of Turmeric.

[0022] Wash the fake columbine, drain, dry, and crush it into 60 mesh fake columbine powder; put the fake columbine powder into supercritical CO 2 The extraction kettle of the extraction device is equipped with an ultrasonic generator, and then the extraction is carried out. The supercritical CO 2 The extraction conditions are: extraction vessel pressure 35MPa, temperature 55°C, separation vessel I pressure 25MPa, temperature 35°C, separation vessel II pressure 12MPa, temperature 50°C, CO 2 The circulating flow rate is 11kg / h, the extraction time is 4 hours; the ultrasonic auxiliary extraction conditions are: ultrasonic frequency 15KHz, ultrasonic power density 120W / L; after vacuum distillation, the materi...

Embodiment 2

[0024] In the embodiment of the present invention, a Chinese medicinal preparation for treating hand, foot and mouth disease is composed of the following raw materials in parts by weight: 28 parts of pseudo columbine, 15 parts of white peony root, and 11 parts of turmeric.

[0025] Wash the fake columbine, drain, dry, and crush it into 80 mesh fake columbine powder; put the fake columbine powder into supercritical CO 2 The extraction kettle of the extraction device is equipped with an ultrasonic generator, and then the extraction is carried out. The supercritical CO 2 The extraction conditions are: extraction vessel pressure 35MPa, temperature 60°C, separation vessel I pressure 25MPa, temperature 40°C, separation vessel II pressure 12MPa, temperature 55°C, CO 2 The circulating flow rate is 12kg / h, the extraction time is 4.5 hours; the ultrasonic auxiliary extraction conditions are: ultrasonic frequency 18KHz, ultrasonic power density 130W / L; after vacuum distillation, the material i...

Embodiment 3

[0027] In the embodiment of the present invention, a Chinese medicinal preparation for treating hand, foot and mouth disease is composed of the following raw materials in parts by weight: 24 parts of pseudo columbine, 12 parts of peony root, and 6 parts of turmeric.

[0028] Wash the fake columbine, drain, dry, and crush into 70 mesh fake columbine powder; put the fake columbine powder into supercritical CO 2 The extraction kettle of the extraction device is equipped with an ultrasonic generator, and then the extraction is carried out. The supercritical CO 2 The extraction conditions are: extraction vessel pressure 35MPa, temperature 57°C, separation vessel I pressure 25MPa, temperature 37°C, separation vessel II pressure 12MPa, temperature 52°C, CO 2 The circulating flow rate is 11.5kg / h, and the extraction time is 4.2 hours; the ultrasonic auxiliary extraction conditions are: ultrasonic frequency 16KHz, ultrasonic power density 125W / L; after vacuum distillation, the material is di...

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating the hand-foot-and-mouth disease and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from, by weight, 22-28 parts of paraquilegia microphylla, 10-15 parts of radix paeoniae alba and 5-11 parts of radix curcumae. Paraquilegia microphylla is thoroughly washed, dewatered, dried and smashed, the powder is subjected to supercritical CO2 extraction, ultrasonic-assisted extraction, reduced pressure distillation and spray drying, and then paraquilegia microphylla extract is obtained; radix paeoniae alba and radix curcumae are thoroughly washed, dried and smashed, the powder is subjected to enzymolysis, microwave treatment and concentration, and radix paeoniae alba and radix curcumae extract is obtained; the paraquilegia microphylla extract is put in the radix paeoniae alba and radix curcumae extract, water is added for heat treatment, the mixture is cooled to room temperature, and the traditional Chinese medicine preparation is obtained. Under the synergistic effect of all the raw materials, when the traditional Chinese medicine preparation is used for treating the hand-foot-and-mouth disease, the advantages that the curative effect is good, effect taking is rapid, no toxic or side effect exists, and relapse is avoided after healing are achieved, and according to clinical statistics, the cure rate is 92% or above, and the effective rate is 98% or above.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating hand, foot and mouth disease, and a preparation method and application thereof. Background technique [0002] Hand, foot and mouth disease is an infectious disease caused by enteroviruses. There are more than 20 types of enteroviruses that cause hand, foot and mouth disease, of which Coxsackie virus A16 (CoxA16) and enterovirus 71 (EV71) are the most common. It mostly occurs in children under 5 years old, with mouth sore, anorexia, low fever, small herpes or small ulcers in the hands, feet, mouth and other parts. Most children heal on their own in about a week. A few children can cause myocarditis, pulmonary edema, and sterility Complications such as meningoencephalitis. Individual severely ill children developed rapidly, leading to death. At present, there is a lack of effective therapeutic drugs and mainly symptom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P31/14
CPCA61K36/9066A61K36/65A61K36/71A61K2236/19A61K2236/33A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈杏芬
Owner 陈杏芬