Preparation method of a highly sensitive nano-zirconia-doped dezocine molecularly imprinted electrochemical sensor

A nano-zirconia, molecular imprinting technology, applied in the direction of material electrochemical variables, can solve the problems of low sensitivity, poor cross-linking rigidity, and inability to properly match functional monomers and template molecules.

Inactive Publication Date: 2017-11-28
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method of a highly sensitive nano-zirconia-doped dezocine molecularly imprinted electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of dezocine molecularly imprinted electrochemical sensor

[0017] To 10.0mL solvent ethanol, add 0.4mmol template molecule dezocine, 2.0mmol functional monomer (5s, 8s)-3-(4'-chloro-3'-fluoro-4-propenylbiphenyl) -3-yl)-4-hydroxyl-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one, 5mmol crosslinking agent maleic rosin ethylene glycol acrylate, 0.25mmol initiation Azobisisobutyronitrile and 0.0350g of nano-zirconia, each chemical reagent added ultrasonically dissolved for 9 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. The t...

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Abstract

The present invention discloses a method for preparing a high-sensitivity nano-zirconia-doped dezocine molecular imprinting electrochemical sensor, the high-sensitivity nano-zirconia-doped dezocine molecular imprinting electrochemical sensor is prepared by use of dezocine as a template molecule, (5s, 8s)-3-(4'-chloro-3'-fluoro-4-propenyl-biphenyl-3-yl)-4-hydroxy-8-methoxy-1-aza-spiro [4.5] dec-3-ene-2-one as a single function monomer, azobisisobutyronitrile as an initiator, nano-zirconia as a dopant and maleic rosin ethylene glycol acrylate as a crosslinking agent, wherein the maleic rosin ethylene glycol acrylate is prepared from rosin as a raw material, and the method is simple and practical, and overcomes the shortcomings that a conventional analysis method is complicated, expensive in equipment, and low in sensitivity.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a highly sensitive nanometer zirconia-doped dezocine molecularly imprinted electrochemical sensor. Background technique [0002] The main function of dezocine is for analgesia, and it is mainly used for postoperative intramuscular injection to relieve pain. However, excessive use of such drugs can cause side effects such as disorientation, hallucinations, sweating, and tachycardia. It poses a fatal risk to humans and is therefore listed as a controlled drug in most countries of the world. [0003] The methods for determination of dezocine include ultraviolet spectroscopy, high performance liquid chromatography gradient elution method, reversed phase high performance liquid chromatography-diode array method and so on. However, these methods have the disadvantages of high cost, long time-consuming, or low sensitivity due to the need for expe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26
CPCG01N27/26
Inventor 余会成韦贻春李浩雷福厚陈其锋谭学才
Owner GUANGXI UNIV FOR NATITIES
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