A traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens and preparation method thereof

A technology for green-shelled laying hens and a composition is applied in the directions of pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc., and can solve the problems of infringing the reproductive tract, short intestines of quails, antibiotic-resistant antibiotics, etc. Improve the survival rate and improve the therapeutic effect

Inactive Publication Date: 2019-10-18
SICHUAN AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the hot and humid summer, the chicken house is low, the ventilation is not good, the house temperature rises, and the daily drinking water of the laying hens increases, causing diarrhea. At the same time, the temperature is high in summer, and microorganisms are easy to breed. Timely disinfection will lead to the growth of various bacteria and molds. Generally, Escherichia coli, Salmonella, and Pasteurella are more common, which can easily cause enteritis and lead to a decrease in the egg production rate of laying hens, and bacterial infections may directly invade the reproductive tract. It can also lead to a decrease in laying hen egg production
[0004] At present, the methods for the prevention and control of Escherichia coli, Salmonella, and Pasteurella in green-shell hens are mainly antibiotics such as gentamicin, apramycin, and florfenicol. The main problems are drug resistance and antibiotic residues. question
However, traditional Chinese medicine compound preparations, such as Huanglian Jiedu Powder, Pulsatilla Pulsatilla Powder, etc., have large particles and short intestines of quail, so the absorption of Chinese medicine powder is limited, resulting in ineffective effects; at the same time, the cost of other compound prescriptions is relatively high

Method used

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  • A traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens and preparation method thereof
  • A traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens and preparation method thereof
  • A traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens and preparation method thereof

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preparation example Construction

[0022] The present invention also provides a preparation method of a traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens, such as figure 1 shown, including the following steps:

[0023] Step 1, pretreatment: dry and pulverize the burnet, yellow root, donkey grass, salvia miltiorrhiza and tangerine peel and pass through a 60-mesh sieve;

[0024] Step 2, Weighing: Weigh the pretreated components in step 1 according to parts by mass: 2-4 parts of Burnet, 1-4 parts of yellow root, 1-3 parts of syringa, 1-3 parts of Salvia miltiorrhiza 0.5-2 parts of tangerine peel;

[0025] Step 3, reflux extraction of the weighed components twice, the first time 15 times the amount of water, reflux extraction for 2 hours, the second time 10 times the amount of water, reflux extraction for 1 hour, combine the filtrates, and place overnight ;

[0026] Step 4, concentrate the combined filtrate to 1:1 (that is, 1 gram of crude drug per milliliter of medic...

Embodiment 1

[0029] Take 250 grams of Burnet, 200 grams of yellow root, 200 grams of japonica, 200 grams of Salvia miltiorrhiza, and 150 grams of tangerine peel, dry them and crush them through a 60-mesh sieve. The preparation method is to weigh the above-mentioned traditional Chinese medicine materials respectively and carry out reflux extraction. A total of 2 extractions, the first time 15 times the amount of water, reflux extraction for 2 hours, the second time, 10 times the amount of water, reflux extraction for 1 hour; and the filtrate was placed overnight, filtered, and the filtrate was concentrated to 1: 1. Add ethanol to make the volume concentration of the filtrate reach 75%, static precipitation, take the supernatant and concentrate, recover the ethanol until it has no alcohol smell, adjust the pH value to 6 with 2mol / L HCl, adjust the total amount with water for injection, which is equivalent to Raw medicinal material 1g / mL, stir well, fill; sterilize at 121°C for 15min. This p...

Embodiment 2

[0031] Take 300 grams of Burnet, 250 grams of yellow root, 250 grams of japonica, 150 grams of Salvia miltiorrhiza, and 100 grams of tangerine peel, dry them and crush them through a 60-mesh sieve. The preparation method is to weigh the above-mentioned traditional Chinese medicine materials respectively and carry out reflux extraction. A total of 2 extractions, the first time 15 times the amount of water, reflux extraction for 2 hours, the second time, 10 times the amount of water, reflux extraction for 1 hour; and the filtrate was placed overnight, filtered, and the filtrate was concentrated to 1: 1. Add ethanol to make the volume concentration of the filtrate reach 75%, static precipitation, take the supernatant and concentrate, recover the ethanol until it has no alcohol smell, adjust the pH value to 6 with 2mol / L HCl, adjust the total amount with water for injection, which is equivalent to Raw medicinal material 1g / mL, stir well, fill; sterilize at 121°C for 15min. This p...

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Abstract

The invention discloses a traditional Chinese medicine composition used for bacteriostasis in vitro of blue-shell chickens. The traditional Chinese medicine composition is prepared from the following ingredients in parts by mass: 2-4 parts of garden burnet, 1-3 parts of prismatomeris tetrandra, 1-3 parts of marsh marigold, 1-3 parts of the root of red-rooted salvia and 0.5-2 parts of pericarpium citri reticulatae. The invention also discloses a preparation method of the traditional Chinese medicine composition used for the bacteriostasis in vitro of the blue-shell chickens. The traditional Chinese medicine composition disclosed by the invention improves the survival rate, the laying rate, the average egg weight, the feed-grain ratio and the like of salmonella-contaminated chickens, and has a good treating function.

Description

technical field [0001] The application belongs to the field of veterinary pharmaceuticals, and in particular relates to a traditional Chinese medicine composition for antibacterial in vitro of green-shell laying hens and a preparation method thereof. Background technique [0002] For a long time, our country has mainly used antibiotics to prevent and treat bacterial infections in veterinary clinics. However, with the widespread use of antibiotics, a series of problems such as allergic reactions, toxic reactions, veterinary drug residues and drug resistance have become increasingly prominent. . In order to deal with such problems, it is urgent to find other safe and effective antibacterial drugs to replace or reduce the use of antibiotics to meet the needs of veterinary clinics. According to the latest research at home and abroad, traditional Chinese medicine or natural plant extracts can directly kill pathogenic bacteria or indirectly exert the effect of preventing and curi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P31/04
Inventor 舒刚赵小玲李霞辉林居纯王志刚符华林尹立子吕程殷中琼朱庆
Owner SICHUAN AGRI UNIV
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