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Method for structuring motion sickness model of dragon tiger panacea

A construction method and technology of dynamic models, applied in the field of motion sickness model construction, can solve problems such as unclear ingredients and material basis of unfavorable drug efficacy

Inactive Publication Date: 2016-07-06
SHANGHAI ZHONGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no relevant report on the pharmacokinetics of Longhurendan in motion sickness model animals, and the ingredients absorbed into the body are not clear, which is not conducive to determining the material basis of its drug effect

Method used

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  • Method for structuring motion sickness model of dragon tiger panacea
  • Method for structuring motion sickness model of dragon tiger panacea
  • Method for structuring motion sickness model of dragon tiger panacea

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Experimental program
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Effect test

Embodiment 1

[0028] 1. Materials and methods

[0029] 1.1. Animals

[0030] Clean grade Wistar rats (250±20g) were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine. The temperature of the breeding room was 23±2°C, the humidity was 60±5%, and the light and dark cycle was 12 hours. After the animals acclimated to the environment for 3 days, they were fasted for 12 hours before the experiment and had free access to water.

[0031] 1.2. Establishment of motion sickness model

[0032] After the animals are adaptively fed for 3 days, they are put into the animal seasickness simulator without restraint for simulated seasickness stimulation, that is, clockwise at an acceleration of 16° / s 2 , accelerating from a speed of 0 to 120° / s, and then immediately at 48° / s 2 Decelerate to 0, stop for one second, and then accelerate counterclockwise at 16° / s 2 Accelerate from speed 0 to 120° / s, then 48° / s 2 Reduce the speed to 0, and continue to stimulate ...

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Abstract

The method for constructing the motion sickness model of Long Hu Ren Dan comprises the following steps: (1) animal preparation: clean rats; (2) establishment of motion sickness model; (3) administration and sample collection; (4) Sample determination and (5) pharmacokinetic analysis and statistical analysis, calculate the plasma drug concentration of the active ingredient in the corresponding batch through the accompanying standard curve of each determination batch, and obtain the concentration-time data. In this study, the 8 non-volatile components LC-MS / MS and 4 volatile components HS-SPDE-GC-MS / MS biological sample analysis methods in Longhu Rendan were used to study the normal and Pharmacokinetic study rules in rats with motion sickness. The results of the present invention can provide help for understanding the anti-motion sickness medicinal substance of Longhuren Dan.

Description

technical field [0001] The invention relates to a method for constructing a motion sickness model of Longhurendan, in particular to the research on the pharmacokinetics of Longhurendan in motion sickness models and normal rats. Background technique [0002] Motion sickness (MS) refers to a series of symptoms of autonomic dysfunction that occurs when the linear or angular acceleration of the environment in which a person or animal lives changes, manifested as dizziness, nausea, vomiting, cold sweat, paleness, etc. Traditional Chinese medicine, especially the compound Chinese medicine, has unique thinking and practical advantages in the prevention and treatment of motion sickness. [0003] There is no relevant report on the pharmacokinetics of Longhurendan in motion sickness model animals, and the components absorbed into the body are not clear, which is not conducive to determining the material basis of its drug effect. Contents of the invention [0004] The object of the ...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K36/9068A61P1/08
CPCA61K49/0008A61K31/045A61K36/285A61K36/48A61K36/484A61K36/54A61K36/57A61K36/61A61K36/67A61K36/899A61K36/9064A61K36/9068
Inventor 金家骅丁礼琴朱丽曹无介马越鸣王天明
Owner SHANGHAI ZHONGHUA PHARMA
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