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A kind of rakicidins compound rakicidin B1 and its preparation method

A compound and structural formula technology, applied in biochemical equipment and methods, microorganism-based methods, microorganisms, etc., can solve the problem of high recurrence rate

Active Publication Date: 2019-01-11
FUJIAN INST OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Anaerobic Clostridium difficile infection is the primary cause of antibiotic-associated diarrhea in hospitals. Metronidazole, vancomycin, and fetamycin are currently recommended drugs for the treatment of Clostridium difficile infection. High relapse rates after either nidazole or vancomycin treatment, urgent need for new therapeutic agents

Method used

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  • A kind of rakicidins compound rakicidin B1 and its preparation method
  • A kind of rakicidins compound rakicidin B1 and its preparation method
  • A kind of rakicidins compound rakicidin B1 and its preparation method

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Experimental program
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Embodiment 1

[0036] Preparation of RakicidinB1

[0037] Step 1: The fermentation and culture conditions of Micromonospora strain FIM02-523 refer to the literature (Jiang Hong, Lin Ru, Zheng Wei, etc. The separation, identification and biological biological activity [J]. Chinese Journal of Antibiotics, 2006, 31(5): 267-270).

[0038] Step 2: Centrifuge the FIM02-523 fermentation broth obtained in Step 1 at 4500rpm for 15 minutes to obtain the mycelium residue, soak the obtained mycelium residue with 2 times the volume of anhydrous methanol or ethanol overnight, and sterilize the bacteria containing alcohol The silk residue was centrifuged again at 4500 rpm for 15 minutes, and the supernatants were combined to obtain a fermentation extract.

[0039] Step 3: HP20 macroporous resin adsorption column chromatography (diameter-to-height ratio 1:5-1:10, column volume 1.5-2.5L): use fermentation extract (40-60L) with 50%-55% Alcohol concentration, the flow rate is 40ml / min for column adsorption; ...

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Abstract

The present invention relates to the field of medicine, in particular to a Rakicidins compound Rakicidin B1. Pharmacodynamic tests have proved that Rakicidin B1 of the present invention has the ability to treat solid tumors such as gastric cancer, liver cancer, breast cancer, pancreatic cancer, intestinal cancer and Diarrhea caused by anaerobic bacteria, digestive tract inflammation, oral inflammation and skin acne and other diseases.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a Rakicidins compound Rakicidin B1. Pharmacodynamic tests have proved that Rakicidin B1 of the present invention has the ability to treat solid tumors such as gastric cancer, liver cancer, breast cancer, pancreatic cancer, intestinal cancer and Diarrhea caused by anaerobic bacteria, digestive tract inflammation, oral inflammation and skin acne and other diseases. Background technique [0002] The anti-cancer drug market has grown rapidly in recent years. In 2014, the global sales of anti-cancer drug market reached 100 billion US dollars; by 2018, the anti-cancer drug market will reach 147 billion US dollars, with a compound growth rate of 11.6%. The research and development of anti-cancer drugs will make huge profits . Hypoxia is one of the characteristics of malignant solid tumors. Hypoxia is closely related to tumor angiogenesis, invasion and metastasis, resistance to radiother...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/062C12P21/02C12N1/20A61K38/05A61P35/00A61P31/04A61P1/12A61P29/00A61P1/00A61P1/02A61P17/10C12R1/29
CPCA61K38/00C07K5/06017C12P21/02C12N1/205C12R2001/29
Inventor 林风江红连云阳王传喜江宏磊赵薇陈丽周剑方东升陈晓明
Owner FUJIAN INST OF MICROBIOLOGY
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