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Bile acid components and medicinal uses of bear bile

A technology of bear bile and active ingredients, applied in the field of bile acid components and the medical use of bear bile

Active Publication Date: 2019-01-29
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many models cannot fully simulate the symptoms of clinically depressed patients, it is certain that stress can cause depression

Method used

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  • Bile acid components and medicinal uses of bear bile
  • Bile acid components and medicinal uses of bear bile
  • Bile acid components and medicinal uses of bear bile

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Antidepressant Pharmacodynamic Study of Bear Bile

[0046] Material:

[0047] Bear bile powder sample source: Heilongjiang Heibao Pharmaceutical Co., Ltd., batch number: 150516+20141112.

[0048] method:

[0049] 1. Establishment and administration of chronic unpredictable stress depression mouse model

[0050] Four-week-old male C57BL / 6 mice were adaptively fed for two weeks after purchase, and were randomly divided into blank control group, model group, positive drug group (venlafaxine 12.5 mg / kg), bear bile powder low-dose group (low 0.05g / kg), bear bile powder middle dose group (middle0.1g / kg), bear bile powder high dose group (high 0.2g / kg), 12 to 16 animals in each group. The mice in the blank group were reared normally with 4 mice per cage, and the mice in the other groups were housed alone in a single cage, and given the following stimuli from time to time every day: ① restraint for 3 hours, ② reverse day and night for 48 hours, ③ fasting for 24 hou...

Embodiment 2

[0056] Example 2 Detection of bile acid components in bear bile and research on antidepressant pharmacodynamics

[0057] 1. Detection of bile acid components in bear bile by UPLC-MS

[0058] 1.1. Standard total ion chromatogram

[0059] Using UPLC-MS full-scan mode to scan the standard, the fingerprint results are as follows: figure 2 .

[0060] Preparation of reference substance solutions: Take 2 mg of each of the 16 bile acid reference substances (Table 1), weigh them accurately, add 1 mL of methanol to dissolve them, and prepare 2 mg / mL solutions of each reference substance. Take an appropriate amount of each reference substance solution, add methanol and mix to make a mixed reference substance solution of 100 μg / mL.

[0061] Table 1

[0062]

[0063] Bear bile powder sample source: Heilongjiang Heibao Pharmaceutical Co., Ltd., batch number: 150516+20141112.

[0064] Chromatographic conditions: chromatographic column is ACQUITY UPLC BEH column (1.7μm, 1.0mm×100mm);...

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Abstract

The invention relates to the field of medicine, in particular to medical application of a bile acid ingredient and bear bile.The bile acid ingredient and the bear bile can be applied to prevention and treatment of depression.

Description

technical field [0001] The invention relates to the field of medicine and health products, in particular to a bile acid component and the medical application of bear bile. Background technique [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, and even suicidal thoughts and behaviors in severe cases. In the study of modern epidemics, depression has become the focus of human attention, and it is expected that it will develop into the second largest disease after coronary heart disease in the next few years, seriously endangering human health and life. [0003] Antidepressant drugs commonly used in clinical practice include tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, etc., often have side effects or are relatively expensive, limiting their wide clinical application. Through drug treatment, most patients can obtain different degrees ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K35/413A61P25/24
CPCA61K31/575A61K35/413
Inventor 吴晓俊王峥涛黄菲郑方周强
Owner SHANGHAI UNIV OF T C M