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Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof

A technology of levamisole hydrochloride and oral liquid, which is applied to medical preparations containing active ingredients, liquid delivery, and pharmaceutical formulas, which can solve problems such as troublesome use, prevent parasitic infections, and improve anti-stress effects and immunity Effect

Active Publication Date: 2018-04-13
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, levamisole deworming drugs are mostly injections on the market, which is quite troublesome to use in animal husbandry

Method used

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  • Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0056] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0057] (3) Take 5L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0058] (4) Add 2.0kg of levamisole hydrochloride, 400g of cobalt sulfate, 50g of disodium edetate, 100ml of Tween-80 and 300g of sodium citrate, add water to 100L, stir well, and homogenize while stirring machine;

[0059] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

Embodiment 2

[0061] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0062] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0063] (3) Take 8L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0064] (4) Add 2.0kg of levamisole hydrochloride, 400g of cobalt sulfate, 50g of disodium edetate, 100ml of Tween-80 and 300g of sodium citrate, add water to 100L, stir well, and homogenize while stirring machine;

[0065] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

Embodiment 3

[0067] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0068] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0069] (3) Take 5L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0070] (4) Add 3.0kg levamisole hydrochloride, 400g cobalt sulfate, 50g disodium edetate, 100ml Tween-80 and 300g sodium citrate, add water to 100L, stir evenly, and homogenize while stirring machine;

[0071] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

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Abstract

The invention discloses a veterinary compound levamisole hydrochloride suspension oral liquid and a preparation method thereof; the compound levamisole hydrochloride suspension oral liquid consists of levamisole hydrochloride, losalamide, cobalt sulfate, agar powder, suspending agent, Composition of wetting agent, disodium edetate, surfactant, etc. The present invention is based on levamisole hydrochloride and losalamide, wetting with a wetting agent, utilizing the dispersing properties of surfactants and the suspending properties of suspending agents, to form a stable and uniform under the action of mechanical shear force Dispersion system, made into a compound suspension oral liquid, deworming cattle, sheep, etc. by mixing materials or mixing drinking water, etc., to treat and prevent parasites such as gastrointestinal nematodes and lung nematodes in clinical and animal production Infection, and can improve the anti-stress effect and immunity of animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to a compound levamisole hydrochloride suspension oral liquid for animals and a preparation method thereof. Background technique [0002] Gastrointestinal nematodes are a general term for parasitic diseases caused by various nematodes that live in the digestive tract. There are many kinds of nematodes, they are widely distributed, and most of them are mixed infections. They are one of the important parasitic diseases of livestock and cause serious economic losses to animal husbandry. There are many parasites in cattle and sheep, which often cause certain economic losses to the animal husbandry due to insufficient attention or improper prevention and treatment. [0003] Levamisole hydrochloride is the hydrochloride salt of levamisole. It is a broad-spectrum, high-efficiency, and low-toxicity anthelmintic drug commonly used in veterinary clinics and animal production. There...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/609A61K9/10A61P33/10A61K31/429
Inventor 吴俊伟姜波陈红伟邓开峰
Owner CHONGQING BULL ANIMAL PHARMA
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