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Application of ulinastatin containing composition to preparation of medicines for treating bladder cancers

A technology for ulinastatin and a composition is applied in the field of preparing medicines for the treatment of bladder cancer, can solve the problems such as that ulinastatin has not been found yet, and achieve the effects of significant curative effect and low toxic and side effects

Inactive Publication Date: 2016-07-27
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching, there is no research about ulinastatin, somatostatin alone, or combination of ulinastatin and somatostatin in the treatment of bladder cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Ulinastatin

[0018] Preparation process: take prescribed amount of ulinastatin and somatostatin, dissolve in 500ml of 0.9% normal saline injection, filter, pot, and sterilize at 100°C for 30 minutes.

Embodiment 2

[0020] Ulinastatin

[0021] Preparation process: take prescribed amount of ulinastatin and somatostatin, dissolve in 500ml of 0.9% normal saline injection, filter, pot, and sterilize at 100°C for 30 minutes.

Embodiment 3

[0023] Ulinastatin

[0024] Preparation process: Take prescription amount of ulinastatin and somatostatin, add 20 grams of mannitol to dissolve, adjust pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity, sterile filter, sub-package Freeze-dried under aseptic conditions in 1000 vials to obtain the product.

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PUM

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Abstract

The invention belongs to the technical field of medicines and particularly discloses application of an ulinastatin containing composition to preparation of medicines for treating bladder cancers. The composition comprises ulinastatin and somatostatin. According to animal experiments, the composition has an evident inhibition effect on human bladder cancer xenografts in nude mice, and the composition is low in toxic and side effect and can be used as a medicine for treating bladder cancers.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of a composition containing ulinastatin in preparing a medicine for treating bladder cancer. Background technique [0002] Bladder cancer refers to malignant tumors that occur on the bladder mucosa. It is the most common malignant tumor of the urinary system and one of the ten most common tumors in the world. It accounts for the first place in the incidence of urogenital tumors in my country, and ranks second in the West after prostate cancer. Bladder cancer can occur at any age, even in children, and its incidence increases with age, with the highest incidence age being 50-70 years old. The incidence of bladder cancer in men is 3-4 times that of women. 70-80% of bladder cancer is superficial bladder cancer, which seriously threatens people's health and quality of life. [0003] The etiology of bladder cancer is complex, including both internal genetic fact...

Claims

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Application Information

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IPC IPC(8): A61K38/57A61P35/00A61K38/12
CPCA61K9/0019A61K38/12A61K38/57A61K2300/00
Inventor 宋建东叶晓春孙明晖侯维静赵菁
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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