Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1

A fused, selected technique, for use in conditions or diseases, in the field of preparation of compounds as defined herein, capable of solving problems such as inactivity
CN105814040BActive Publication Date: 2019-07-30CANCER RES TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CANCER RES TECH LTD
Publication Date
2019-07-30

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Abstract

The present invention relates to compounds of formula I, wherein A 1 、A 2 , R 4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and / or prevention of proliferative diseases such as cancer. The invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising these compounds.
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Description

[0001] introduction

[0002] The present invention relates to novel compounds that act as inhibitors of heat shock factor 1 (HSF1) activity. The invention also relates to processes for the preparation of the compounds defined herein, pharmaceutical compositions comprising them, and their use in the treatment of HSF1 -mediated conditions or diseases such as cancer, autoimmune and viral diseases.

[0003] Background of the invention

[0004] Cancer arises from uncontrolled and unregulated cell proliferation. Precisely what causes cells to become malignant and proliferate in an uncontrolled and unregulated manner has been the focus of intense research in recent decades. This research has led to the identification of many molecular targets associated with key metabolic pathways known to be associated with malignancy.

[0005] Heat shock factor 1 (HSF1) is one such target molecule. HSF1 is a master regulator of the heat shock response, in which multiple genes are induced in respo...

Claims

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