Preparation method of radix tetrastigme polysaccharide particle with antitumor function
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An anti-tumor effect, the technology of cloverleaf, applied in the field of medicine, can solve the problem of few Chinese patent medicine preparations, achieve good anti-tumor, low cost, and inhibit tumor growth effects
Active Publication Date: 2016-08-03
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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[0005] The purpose of the present invention is to provide a preparation method of Clover polysaccharide particles ...
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Embodiment 1
[0036] Preparation of Clover polysaccharide
[0037] Take the aboveground part or tuber of Clover 35-65℃ and dry it in an oven, dry it to constant weight and crush it, weigh the corresponding required amount, put it into a round bottom flask, and add double distilled water to reflux according to the material ratio of 1:15 Extract 3 times, 30min each time. After filtration, the extracts were combined for 3 times, concentrated by distillation under reduced pressure, 95% ethanol with 3 times the mass of the concentrated solution was added, water extracted and ethanol precipitated 3 times, and after standing overnight at 4°C, centrifuged at 4200 rpm for 15 minutes at a high speed to obtain a precipitate. The precipitate was washed twice with absolute ethanol, and freeze-dried in a vacuum to obtain a trifoliate polysaccharide powder.
Embodiment 2
[0039] Preparation of Clover Polysaccharide Granules
[0040] Get the 100g Clover polysaccharide powder prepared in Example 1, 200g hydroxypropyl methylcellulose, 150g microcrystalline cellulose, pass through a 100 mesh sieve after mixing evenly, add 20g1-5% ethanol solution of ethylcellulose, 50g Dry at ℃ for 5 hours, then sieve through a 20-mesh sieve for granulation, add 4g of micropowder silica gel, and mix well to obtain the trefoil polysaccharide granule preparation.
Embodiment 3
[0042] Preparation of Clover Polysaccharide Granules
[0043]Get 100g Clover polysaccharide prepared in Example 1, 200g ethyl cellulose, 150g lactose, mix evenly and pass through a 100 mesh sieve, add 20g of 1-5% ethyl cellulose ethanol solution, dry at 50°C for 5 hours, then Sieve through a 20-mesh sieve for granulation, add 4g of magnesium stearate, and mix well to obtain the trefoil polysaccharide granule preparation.
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Abstract
The invention relates to a preparation method of a radix tetrastigme polysaccharide particle with an antitumor function. Radix tetrastigme polysaccharide is the active component, and other pharmaceutical auxiliary materials such as sustained release material, filling agent, adhesive, lubricant, and the like, are added to prepare the particle. Various transplantation tumor mouse models and in-vitro lymphocyte proliferation assay are used to evaluate the effect of radix tetrastigme polysaccharide particle on preventing tumors and enhancing immunity, the effect is good; compared with chemotherapeutic drugs, the side and toxic effects are less, and thus the radix tetrastigme polysaccharide particle has a good application prospect in antitumor aspect. The radix tetrastigme polysaccharide particle is user-friendly, can be directly swallowed or dissolved into water and then eaten, is bad in dustability, adhesiveness, and hygroscopicity, and has a stable drug content.
Description
technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a preparation method of trefoil polysaccharide granules used in anti-tumor. Background technique [0002] Cancer is a worldwide disease and has become the primary enemy that threatens human life and health, and its incidence is also increasing year by year. According to a research report released by the World Health Organization (WHO), 14 million people were diagnosed with cancer in 2012 alone, and it is predicted that new cancer cases worldwide will increase by nearly half in 2035, and the incidence and mortality of cancer continue to rise. [0003] In the treatment of cancer, drug treatment is a very important link. The use of effective anticancer drugs can help patients survive longer and have hope of survival. Chemotherapy is a routine treatment for clinical tumors, but the effect of chemotherapeutic drugs lacks selectivity. While killing tumor cells...
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