Anti-BASIGIN humanized antibody and application thereof

A technology of humanized antibodies and monoclonal antibodies, which is applied in the fields of antibodies, anti-infective drugs, anti-tumor drugs, etc., and can solve problems such as allergic and toxic reactions and blocking antibodies

Active Publication Date: 2016-08-03
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the repeated injection of mouse McAb into the human body will cause the patient to induce human antimouse antibody (human antimouse antibody, HAMA) reaction, cause systemic allergic toxicity and block the efficacy of the antibody

Method used

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  • Anti-BASIGIN humanized antibody and application thereof
  • Anti-BASIGIN humanized antibody and application thereof
  • Anti-BASIGIN humanized antibody and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0043] 1. Terminology Explanation:

[0044] Immunoglobulin refers to a class of structurally related glycoproteins consisting of two pairs of polypeptide chains, a pair of low molecular weight light chains (L) and a pair of high molecular weight heavy chains (H), all four chains passing through Disulfide bonds link each other. Each heavy chain typically consists of a heavy chain variable region (abbreviated herein as VH) and a heavy chain constant region (abbreviated herein as CH). Each light chain typically consists of a light chain variable region (abbreviated herein as VL) and a light chain constant region (abbreviated herein as CL). The light chain constant region typically consists of one domain, CL. VH and VL can be further subdivided into hypervariable regions (or hypervariable hypervariable regions in sequence and / or in the form of structurally defined loops), also known as complementarity determining regions (CDRs), interspersed with more conserved region, known as...

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Abstract

The invention discloses an anti-BASIGIN humanized antibody and application thereof. The antibody contains an immunoglobulin light-chain variable region and an immunoglobulin heavy-chain variable region, wherein the immunoglobulin light-chain variable region contains CDR1 shown as SEQ ID NO:13 in a sequence table, CDR2 shown as SEQ ID NO:14 in the sequence table and CDR3 shown as SEQ ID NO:15 in the sequence table, the immunoglobulin heavychain variable region contains CDR1 shown as SEQ ID NO:16 in the sequence table, CDR2 shown as SEQ ID NO:17 in the sequence table and CDR3 shown as SEQ ID NO:18 in the sequence table. The anti-BASIGIN humanized antibody is applied to the preparation of drugs for treating lung cancers, liver cancers and colorectal cancers and the preparation of drugs for treating malaria.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular, the invention provides an anti-BASIGIN humanized antibody and its application. Background technique [0002] BASIGIN (EMMPRIN, Neurothelin, M6antigen, BASIGIN) is a highly glycosylated transmembrane glycoprotein with a molecular weight of 50-60kD, which is a member of the immunoglobulin superfamily (IgSF). In humans, BASIGIN consists of 269 amino acids, which can be divided into extracellular region, transmembrane region and intracellular region. The first 21 residues after N-terminal translation are signal peptides, 22-205 constitute the extracellular region, 206-229 are transmembrane regions with a typical leucine zipper structure, and C-terminal 230-269 is the intracellular region. BASIGIN has been shown to be overexpressed in many types of human solid tumors, such as lung, liver, cervical, colon, breast, ovarian, esophageal or gastric cancer. [0003] Previous studies have shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/42A61K39/395A61P35/00A61P33/06
CPCC07K16/4241C07K2317/565C07K2317/567C07K2317/73C07K2317/92C07K2317/76C07K2317/24A61K39/395C07K16/42C07K16/005C07K16/2803C07K2317/622A61P1/04A61P1/16A61P11/00A61P15/00A61P33/06A61P35/00Y02A50/30A61K2039/505A61K9/0019C07K16/32
Inventor 陈志南朱平黄婉张征张阳张梦瑶边惠洁蒋建利
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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