A kind of pharmaceutical composition and preparation method for treating hypertension

A composition and high blood pressure technology, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of short drug effect duration, poor drug treatment effect, and long onset time, and achieve long drug effect duration, Improve batch-to-batch uniformity and short onset time

Active Publication Date: 2018-09-14
ZHENGZHOU TAIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the treatment of hypertension, conventional antihypertensive drugs have large blood pressure fluctuations in the process of reducing blood pressure in hypertension, poor drug treatment effect, large side effects, long onset time, and short drug effect duration

Method used

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  • A kind of pharmaceutical composition and preparation method for treating hypertension
  • A kind of pharmaceutical composition and preparation method for treating hypertension
  • A kind of pharmaceutical composition and preparation method for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 pharmaceutical composition tablet and preparation method

[0061] Dissolve reserpine, pentathiazine and hydroxypropyl cellulose in ethanol first, add the other auxiliary materials except lubricant into the fluidized bed granulation coating machine, spray into the above ethanol solution after fluidized mixing After granulation, dry, add lubricant after granulation, mix evenly, and compress into tablets.

[0062](1) Composition formula

[0063] Reserpine 0.3g, hydralazine hydrochloride 10g, pentathiazide 0.25g, hydrochlorothiazide 15g, promethazine hydrochloride 20g, potassium chloride 300g, rutin 50g, chloroquine phosphate 25g, vitamin B1 10g, vitamin B6 10g, rich Malic acid 50g, lactose 613g, croscarmellose sodium 36g, hydroxypropyl cellulose 50g and magnesium stearate 10g.

[0064] (2) Weigh the above raw materials according to step (1), the preparation process is as follows

[0065] ① First, add reserpine and pentathiazine into 1000ml of 95% ethanol, s...

Embodiment 2

[0071] Embodiment 2 pharmaceutical composition tablet and preparation method

[0072] Basically the same as Example 1, the difference is:

[0073] The composition formula of embodiment 2 is:

[0074] Reserpine 0.6g, hydralazine hydrochloride 20g, pentathiazide 0.5g, hydrochlorothiazide 30g, promethazine hydrochloride 40g, potassium chloride 600g, rutin 100g, chloroquine phosphate 50g, vitamin B1 20g, vitamin B6 20g, rich Malic acid 120g, lactose 1300g, croscarmellose sodium 70g, hydroxypropyl cellulose 100g, magnesium stearate 30g.

[0075] Explanation: The purified water and ethanol added in this example are prepared through the preparation method and finally dried to obtain the product, and the added purified water and ethanol are all evaporated;

[0076] The preparation process of the composition of embodiment 2 is the same as embodiment 1.

Embodiment 3

[0077] Embodiment 3 pharmaceutical composition tablet and preparation method

[0078] Basically the same as Example 1, the difference is:

[0079] The composition formula of embodiment 3 is:

[0080] Reserpine 0.3g, hydralazine hydrochloride 10g, pentathiazide 0.25g, hydrochlorothiazide 15g, promethazine hydrochloride 20g, potassium chloride 300g, rutin 50g, chloroquine phosphate 25g, vitamin B1 10g, vitamin B6 10g, rich 50g of malic acid, 315g of lactose, 315g of microcrystalline cellulose, 35g of croscarmellose sodium, 50g of hydroxypropyl cellulose, 5g of micronized silica gel and 10g of magnesium stearate.

[0081] Explanation: The purified water and ethanol added in this example are prepared through the preparation method and finally dried to obtain the product, and the added purified water and ethanol are all evaporated;

[0082] The preparation process of the composition of embodiment 3 is the same as embodiment 1.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating hypertension and a preparation method thereof and aims to overcome the defects of the preparation method of a compound reserpine composition. The compound reserpine pharmaceutical composition comprises various active components such as reserpine, hydrochlorothiazide, vitamin B6, potassium chloride and rutin. The prepared compound reserpine pharmaceutical composition has the advantages that the composition is small in toxic and side effects, quick in action and lasting in medicine effect, blood pressure fluctuation is small during blood pressure lowering, long-term treatment of a patient is facilitated, medicine use safety is increased, and medicine use compliance is improved; in addition, the dissolution difference of the compound reserpine pharmaceutical composition can be lowered evidently, and sample stability and batch-to-batch evenness can be increased.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition for treating hypertension and a preparation method. Background technique [0002] Reserpine is an adrenergic neuron-blocking antihypertensive drug, which achieves antihypertension, slows heart rate and inhibits blood pressure by depleting adrenaline at peripheral sympathetic nerve endings, catecholamines and serotonin in heart, brain and other tissues. The role of the central nervous system. Widely used in the treatment of mild and moderate hypertension; antihypertensive and stable drugs, the antihypertensive effect is slow, but the effect is long-lasting, and the effect disappears slowly after stopping the drug, especially when combined with thiazide diuretics, it has a good effect , is one of the main components of commonly used compound antihypertensive drugs. Hyalalazine hydrochloride is a vasodilator. For moderat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/475A61K31/549A61K31/7048A61K31/51A61K31/4415A61K31/502A61K33/14A61P9/12A61K31/5415A61K31/4706A61K31/194
CPCA61K9/0056A61K9/2054A61K9/2081A61K31/194A61K31/4415A61K31/4706A61K31/475A61K31/502A61K31/51A61K31/5415A61K31/549A61K31/7048A61K33/14A61K2300/00
Inventor 任逢晓杨艳丽王延敏高敬轩
Owner ZHENGZHOU TAIFENG PHARMA CO LTD
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