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Monochiral compound with antidepressant activity and its preparation method and application

A chiral compound and antidepressant technology, applied in the field of medicine and chemical industry, can solve the problems of slow onset, low efficacy, large side effects, etc., and achieve the effects of simple steps, convenient operation and good antidepressant activity

Active Publication Date: 2018-03-27
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Clinically, many traditional antidepressant drugs are facing the problems of low efficacy, slow onset of action, and large side effects, and there is an urgent need to develop new antidepressant drugs

Method used

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  • Monochiral compound with antidepressant activity and its preparation method and application
  • Monochiral compound with antidepressant activity and its preparation method and application
  • Monochiral compound with antidepressant activity and its preparation method and application

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Embodiment Construction

[0021] In order to facilitate the understanding of those skilled in the art, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings, and the contents mentioned in the embodiments are not intended to limit the present invention.

[0022] 1. Preparation of new compounds:

[0023] Take 2.8107g (0.01mol) of 1-(m-trifluoromethylphenyl)-2-bromo-acetone and 35ml (0.363mol) of NMP into the reaction vessel, stir evenly with a magnetic force, then add (R)-2-aminopropanol 3.0044 g (0.04mol), under nitrogen protection, heat and control the temperature to 53°C for 1 hour, cool in an ice bath, add saturated sodium carbonate solution to adjust the pH value to alkaline, add 40ml of anhydrous ether, stir for several minutes, and let stand to separate layers. Suction filtration, the filtrate was extracted with anhydrous ether (20ml×3), the organic layer was washed with distilled water (20ml×3), the organic layer was collected, dr...

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Abstract

A single chiral compound with antidepressant activity and a preparation method and application thereof are related to the technical field of pharmaceutical chemicals. The single chiral compound has a following structural formula. The structure of the compound is different from that of an existing antidepressant compound, and the compound has a novel molecular structure and has good antidepressant activity.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical industry, in particular to a single chiral compound with antidepressant activity and its preparation method and application. Background technique [0002] Depression is a potentially life-threatening mental illness that can cause enormous mental stress to people and even lead to suicide in severe cases. With the rapid development of society and economy and the acceleration of the pace of life, the incidence of depression shows an increasing trend year by year. According to statistics, there are more than 26 million patients with depression in China. Clinically, many traditional antidepressant drugs are faced with the problems of low efficacy, slow onset of action, and large side effects, and there is an urgent need to develop new antidepressant drugs. [0003] Drugs with different chirality (that is, different three-dimensional structure) may exhibit different pharmacokinetic behavi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D265/32A61P25/24
CPCC07D265/32
Inventor 肖新荣郭倩田芳杰郑友霖唐小敏罗甜
Owner NANHUA UNIV