Application of lactobacillus plantarum to preparation of product with liver protecting function

A technology of Lactobacillus plantarum and products, applied in the fields of application, function of food ingredients, medical preparations containing active ingredients, etc., can solve the problems of lack, kidney side effects, liver injury treatment and prevention, etc.

Inactive Publication Date: 2016-11-09
JILIN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing measures are not effective in the treatment and prevention of liver damage, and some drugs will have side effects on the kidneys after taking them
Due to the unclear pathogenesis, there is currently a lack of drugs approved by the FDA for the prevention and treatment of alcoholic liver disease and acute liver injury

Method used

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  • Application of lactobacillus plantarum to preparation of product with liver protecting function
  • Application of lactobacillus plantarum to preparation of product with liver protecting function
  • Application of lactobacillus plantarum to preparation of product with liver protecting function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Embodiment 1, the acquisition of Lactobacillus plantarum C88

[0107] Strain C88 was isolated from milk tofu, a traditional fermented food in Inner Mongolia. It was identified as Lactobacillus plantarum (Lactobacillus plantarum) by API50CHL biochemical reaction and 16srDNA sequence amplification comparison, and named Lactobacillus plantarum C88.

[0108] Lactobacillus plantarum (Lactobacillus plantarum) C88 was deposited in the China Center for Type Culture Collection (CCTCC for short, address: Luojia Mountain, Wuchang, Wuhan, Wuhan University, Zip Code 430072) on November 5, 2009, and the preservation number is CCTCC NO: M 209254.

[0109] Lactobacillus plantarum (Lactobacillus plantarum) C88 has applied for a patent on January 15, 2010 and obtained authorization. The application number is 201010034128.1. The authorization announcement number is CN 101864375B, and the authorization announcement date is November 02, 2011.

Embodiment 2

[0110] Example 2, the protective effect of Lactobacillus plantarum C88 on acute liver injury

[0111] 1. Group processing method

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Abstract

The invention discloses application of lactobacillus plantarum to preparation of a product with a liver protecting function. The preservation number of the lactobacillus plantarum C88 is CCTCC NO: M 209254. The product is food or a health care product or a drug. The main functions of the product include reduction of organism oxidative stress and inflammatory reactions caused by acute liver injuries, promotion of intactness of the intestinal barrier function and effective relief of acute liver injury symptoms. The lactobacillus plantarum C88 or a fungal preparation thereof is taken every day to replace drugs to protect the liver against injuries. The lactobacillus plantarum C88 can serve as functional probiotics to be applied to the fields of food, health care products and drugs and has broad application prospects.

Description

technical field [0001] The invention relates to the application of plantarum lactobacillus in preparing products with functions of protecting the liver. Background technique [0002] Alcoholic liver disease refers to a series of liver damage caused by long-term or excessive alcohol intake. After the body ingests a large amount of alcohol, it will inhibit the tricarboxylic acid cycle and weaken the oxidation of fatty acids, thereby affecting fat metabolism, resulting in fat deposition in liver cells. At the same time, alcohol ingestion can change the structure of the liver and intestines, causing increased sensitivity of the liver and increased intestinal permeability, which in turn leads to intestinal-derived endotoxins entering the blood circulation and stimulating hepatic macrophages to produce inflammation-related cytokines, resulting in Inflammation, necrosis and fibrosis occur in fatty liver. The existing measures are not effective in the treatment and prevention of l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A23L33/135A61P1/16
CPCA61K35/747A23V2002/00A23V2200/32
Inventor 李盛钰段翠翠高磊赵玉娟牛春华栾畅赵文博
Owner JILIN ACAD OF AGRI SCI
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