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Application of a traditional Chinese medicine composition in preparation of medicine for treating renal cancer

A composition and technology of traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve problems such as unsustainable curative effect, difficulty in long-term treatment, and loss of surgery opportunities, so as to avoid recurrence and metastasis, reduce adverse reactions, and improve The effect of medicine

Inactive Publication Date: 2019-08-09
HEILONGJIANG UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment is the most commonly used and most effective method, and it is also the only method currently recognized as a possible cure for renal cancer, but most patients have lost the best opportunity for surgery when they are diagnosed; Drug properties make renal cancer insensitive to radiotherapy, chemotherapy and hormone therapy; α-interferon (INF-α) and interleukin 2 (IL-2) are biological immunotherapeutic preparations that have been studied more at present. Chemotherapy has a certain curative effect, but only some patients have achieved good curative effect, and the curative effect is not long-lasting, and the treatment has brought many adverse reactions, such as nausea, vomiting, bone marrow suppression, etc., which have brought difficulties to long-term treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 capsule

[0018] Preparation of Astragalus water extract: crush Astragalus into coarse powder, add 7 times of water to soak for 1 hour, reflux for 2 hours, filter, and the filtrate for later use, add 5 times of water to the dregs, reflux for 1.5 hours, filter, and combine the two filtrates , concentrated to one-third of the original volume, added 95% ethanol until the alcohol concentration reached 70%, left to stand, precipitated, filtered, dried the resulting precipitate, and ultrafinely pulverized to 300 mesh to obtain the Astragalus water extract .

[0019] Preparation of Solanum solanum ethanol extract: Grind Solanum solanum into coarse powder, add 8 times the amount of 75% ethanol solution, heat and reflux for extraction, extract for 1.5h, filter, and the filtrate is set aside, add 6 times the amount of 75% ethanol The ethanol solution was extracted by heating under reflux, extracted for 1 h, filtered, the two filtrates were combine...

Embodiment 2

[0023] The curative effect test of embodiment 2 Chinese medicine composition treatment kidney cancer

[0024] normal information

[0025] Randomly selected 38 renal cancer patients receiving chemotherapy, including 26 males and 12 females, aged 41.6-70.3 years, with an average age of 55.7 years. The 38 patients were randomly divided into two groups, namely the test group and the control group. There was no statistical difference between the two groups in terms of age, gender, and stage of renal cancer.

[0026] Treatment method: the control group maintained the original chemotherapy administration method, and the test group took the capsules prepared in Example 1, 3 times a day, 3-5 capsules each time, for 3 months.

[0027] Evaluation method: After taking the medicine for 3 months, the liver and kidney function and hematuria of all patients were checked routinely, and the toxic and side effects of the treatment were evaluated. During the follow-up of the patients, B-ultraso...

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Abstract

The invention relates to application of a traditional Chinese medicine composition to preparation of a drug for treating renal carcinoma, and belongs to the field of traditional Chinese medicine application. The traditional Chinese medicine composition is prepared from radix astragali, black nightshade herb and alcohol extract / aqueous extract of herba salviae chinensis. The content of the effective component is increased by the traditional Chinese medicine composition to improve the pharmacological function, when the drug is combined with chemotherapy to treat renal carcinoma, relapse and metastasis of renal carcinoma can be effectively avoided to achieve the effects of reducing toxicity and improving the effect, adverse effects when a patient with renal carcinoma uses the chemotherapy drug for a long time are reduced, and life quality of the patient is improved.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in preparing medicine for treating kidney cancer, belonging to the field of traditional Chinese medicine application. Background technique [0002] Kidney cancer, also known as renal cell carcinoma, originates from renal tubular epithelial cells and can occur in any part of the renal parenchyma, but it is more common in the upper and lower levels. In my country, renal cancer accounts for about 3% of all adult malignant tumors. One of the most common malignant tumors, its incidence rate is second only to bladder cancer, and the older the age, the higher the prevalence rate. The etiology of kidney cancer is not yet clear. On the one hand, it is related to lifestyle factors, such as smoking, drinking, food, obesity, and drugs; on the other hand, it is related to environmental factors, such as occupational exposure to chemical substances, radiation, and kidney dialysis; ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61P35/00
CPCA61K36/481A61K36/53A61K36/81A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 解颖白吉祥王书惠韩洁茹张海丽
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE