Targeted drug-carried nanoscale ultrasound microbubble and preparation method thereof

A technology of drug-loaded nano and ultrasonic microbubbles, which is applied in pharmaceutical formulations, echo/ultrasonic imaging agents, anti-tumor drugs, etc., can solve the problems of single function, low sensitivity, clarity and accuracy, and overcome the problem of single function Effect

Active Publication Date: 2016-11-23
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem of single function of traditional ultrasound contrast agents and low sensitivity, clarity and accuracy, and proposes a targeted drug-loaded nanoscale ultrasonic microbubble and its preparation method

Method used

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  • Targeted drug-carried nanoscale ultrasound microbubble and preparation method thereof
  • Targeted drug-carried nanoscale ultrasound microbubble and preparation method thereof

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0018] Specific embodiment 1: A targeted drug-loaded nanoscale ultrasonic microbubble includes: microbubble membrane wall, FA-CNTs-PTX targeted drug-loaded complex, and inert gas wrapped inside the microbubble membrane wall; wherein the FA is folic acid, CNTs is carbon nanotubes, and PTX is paclitaxel;

[0019] The carbon nanotubes are placed inside the microbubble membrane wall, one end of the targeting factor folic acid is connected to the carbon nanotubes through chitosan, and the other end passes through the microbubble membrane wall to the outside of the microbubble membrane wall, and the carbon nanotubes connected to the folic acid The tubes were loaded with the antineoplastic drug paclitaxel by physical adsorption.

specific Embodiment approach 2

[0020] Embodiment 2: This embodiment differs from Embodiment 1 in that: the microbubble membrane wall is a lipid bilayer structure, and the microbubble membrane wall materials are Span60 and PEG1500.

[0021] Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0022] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the particle size of the targeted drug-loaded nano-scale ultrasonic microbubbles is 400-600 nm.

[0023] Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention relates to a targeted drug-carried nanoscale ultrasound microbubble and a preparation method thereof, and aims at solving the problems that a traditional ultrasound contrast agent has a single function and low sensitivity, definition and accuracy. The targeted drug-carried nanoscale ultrasound microbubble comprises a microbubble membrane wall, an FA-CNTs-PTX targeted drug-carried compound and inert gas wrapped in the microbubble membrane wall, wherein FA is folic acid, CNTs are carbon nanotubes, and PTX is paclitaxel. The preparation method comprises the steps that 1, a folic acid-chitosan conjugate is prepared; 2, the carbon nanotubes are subjected to carboxylation to obtain carboxylation-modified carbon nanotubes; 3, a targeted compound FA-CS-CNTs is prepared; 4, the targeted drug-carried compound FA-CNTs-PTX is prepared; 5, the microbubble composited with the FA-CNTs-PTX is prepared. The targeted drug-carried nanoscale ultrasound microbubble and the preparation method thereof are applied to the field of medical preparations.

Description

technical field [0001] The invention relates to targeted drug-loaded nano-scale ultrasonic microbubbles and a preparation method thereof. Background technique [0002] Ultrasound contrast agents (Ultrasound Contrast Agents, UCAs) are a class of diagnostic drugs that can significantly enhance medical ultrasound detection signals. Through intravenous injection, they reach the microcirculation of various organs of the human body, and microbubbles can significantly enhance the echo signal of the site. An ideal ultrasound contrast agent can be used as a blood pool imaging tracer distributed throughout the body with blood flow, reflecting the blood perfusion of organs without interfering with hemodynamics. Ultrasound contrast agents can effectively enhance the two-dimensional ultrasound images and blood Doppler signals of solid organs such as the myocardium, liver, kidney, and brain, and significantly improve the sensitivity and specificity of ultrasound diagnosis. Good applicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K31/337A61K47/48A61P35/00
CPCA61K31/337A61K49/221A61K49/223
Inventor 张杰胡明张宇刘俊希侯巍张云杰焦淑清张云龙赵越
Owner JIAMUSI UNIVERSITY
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