Chiral heterogeneous compound contained lysine five-dimensional drug combination and purpose thereof

A composition and technology of lysine, applied in the field of medicine, can solve the problems of not being fully suitable for clinical application, not being able to be optimized, D-lysine is not easy to absorb and utilize, etc.

Inactive Publication Date: 2016-12-07
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many deficiencies in the preparations of the prior art. Its lysine hydrochloride contains half of D-lysine and L-lysine, and only L-lysine is easily absorbed and utilized by the body, which has great utilization for the human body. value, and D-lysine is not easy to be absorbed and utilized by the human body; although L-lysine hydrochloride granules whose name is limited to a single optical isomer are also publicly reported, they are limited to single-component administration
In addition, the five-dimensional lysine granules in the prior art are not suitable for patients with hyperchloremia, acidosis, and renal insufficiency in some cases, especially if they are not known or difficult to know in advance. adverse consequences; and the use of L-lysine is not limited in the cur

Method used

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  • Chiral heterogeneous compound contained lysine five-dimensional drug combination and purpose thereof
  • Chiral heterogeneous compound contained lysine five-dimensional drug combination and purpose thereof
  • Chiral heterogeneous compound contained lysine five-dimensional drug combination and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 5

[0041] The preparation of embodiment 1 five-dimensional L-lysine capsules, prescription (1000): L-lysine hydrochloride 50g, vitamin B 1 1.2g, vitamin B 2 0.15g, vitamin B 6 0.075g, niacinamide 2.4g, D-calcium pantothenate or D-calcium pantothenate 2 hydrate 0.15g; preparation process: take prescription amount, L-lysine hydrochloride and vitamin B through a 100-mesh sieve respectively 1 , Vitamin B 2 , vitamins, niacinamide, D-calcium pantothenate, mixed uniformly according to the method of equal incremental dilution, measuring the content of the main drug L-lysine hydrochloride in the granules, filling capsules according to the dosage, packaging, and testing to obtain finished products.

Embodiment 2 5

[0042] The preparation of embodiment 2 five-dimensional L-lysine capsules, prescription (1000): L-lysine 40g, vitamin B 1 1.2g, vitamin B 2 0.15g, vitamin B 6 0.075g, niacinamide 2.4g, D-calcium pantothenate 2 hydrate 0.15g; preparation process: take the prescription amount, each component passed through a 100-mesh sieve, and mix them evenly according to the method of equal-incremental dilution, and measure the main content of the granules. The content of drug L-lysine is filled into capsules according to the dose, packaged and inspected to obtain a finished product.

Embodiment 3

[0043] Example 3 Preparation of L-5-dimensional lysine capsules, prescription (1000 capsules): L-lysine acetate 56.458g, vitamin B 1 1.2g, vitamin B 2 0.15g, vitamin B 6 0.075g, niacinamide 2.4g, D-calcium pantothenate 0.15g; preparation process: take the prescription amount, each component passed through a 100-mesh sieve, mix evenly according to the method of equal incremental dilution, and measure L-lysine hydrochloride in the granules After the content of the acid is qualified, the capsules are filled according to the dose, packaged, inspected, and the finished product is obtained.

[0044] The preparation of embodiment 4L-five-dimensional lysine capsules (prescription (1000) L-lysine hydrochloride 45g, vitamin B 1 1.44g, vitamin B 2 0.12g, vitamin B 6 0.09g, niacinamide 2.12g, D-calcium pantothenate 0.18g, magnesium stearate 1g; preparation process: take the prescription amount, each component passed through a 100-mesh sieve, mix evenly according to the method of equal...

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Abstract

The present invention provides the application in the health food or the medicine of five kinds of vitamins and lysine compositions containing the chiral isomer compound for the prevention or treatment of human and mammal L-lysine deficiency, poor growth and development, etc., so that the product can be used in In clinical use, it has more new adaptation populations or better pertinence and better clinical safety.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to provide prevention or treatment to promote normal growth and development or supplement L-lysine for patients with L-lysine deficiency, or metabolic acidosis, hyperchloremia but need to supplement lysine A five-dimensional pharmaceutical composition of lysine containing chiral isomeric compounds or a pharmaceutical composition of five-dimensional lysine and its preparation and use. Background technique [0002] Lysine is a basic amino acid and has three basic forms: DL-lysine, D-lysine and L-lysine. L-lysine is one of the eight essential amino acids for the human body. L-lysine Provides structural components for the synthesis of carnitine, which drives the synthesis of fatty acids in cells. Especially in the period of child development, recovery after illness, pregnancy and lactation, the demand for L-lysine is higher. Due to its low content in foods such as rice and corn, it i...

Claims

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Application Information

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IPC IPC(8): A61K31/525A23L1/305A61P3/02A61P3/00A61P3/14A61P19/10A61P19/08A61K31/197A61K31/4415A61K31/455A61K31/51A61K31/198
Inventor 刘力
Owner 刘力
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