Plush thread bioartificial liver reactor

Abstract

The invention discloses a plush thread bioartificial liver reactor, which comprises a reactor shell, a plurality of plush threads and a plurality of hollow fiber tubes arranged in the inner cavity of the reactor shell; one end of the reactor shell is provided with a The plasma / preflush inlet and the nutrient solution / liver cell suspension inlet are provided at the other end with the plasma / preflush outlet and the nutrient solution outlet; the two ends of the hollow fiber tube are respectively connected to the plasma / preflush inlet and the The plasma / preflush outlet is connected; the plurality of plush threads and the plurality of hollow fiber tubes are arranged in parallel and alternately at intervals. The beneficial effects of the present invention are: significantly increasing the area of ​​the hepatocytes that can adhere to the wall in the reactor, improving the uniformity of the distribution of the hepatocytes, maintaining good cell activity, and being conducive to the maximum play of the function of the hepatocytes, thereby achieving the best good therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of bioartificial liver, and in particular relates to a plush thread type bioartificial liver reactor. Background technique [0002] The liver undertakes important functions such as detoxification, storage of glycogen, and protein synthesis in the body. Once a large number of liver cells are necrotic for some reason, liver failure will occur, which will lead to metabolic disorders and accumulation of toxic substances, which in turn will aggravate liver cell damage, affect liver cell regeneration, and cause malignant liver failure. cycle. End-stage liver failure can only be cured through liver transplantation, but due to the extreme shortage of liver donors, most patients with liver disease cannot be cured. The artificial liver system is an effective means to prevent the deterioration of the disease and buy time for patients waiting for liver transplantation or regeneration of autologous liver cells. [000...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defects of uneven distribution of hepatocytes, low adherence rate and poor cell activity in the existing bioartificial liver reactor, and provide a method that can effectively increase the adherent area of ​​hepatocytes and promote the formation of hepatocytes in the bioartificial liver. Adhesive growth in the reactor, thereby increasing the growth density and activity of hepatocytes, a plush thread bioartificial liver reactor

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