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Synthetic method for nutrient substances of organ peptides

A technology of nutrients and synthesis methods, applied in the field of organ peptide nutrient synthesis, can solve the problems of inability to inhibit cancer mutation, failure to repair DNA, low absorption and utilization rate, etc., to enhance cellular immunity, improve absorption and utilization rate, Anti-aging effect

Inactive Publication Date: 2016-12-21
SHANGHAI JIAOJIAREN MEDICAL COSMETOLOGY OUT PATIENT DEPT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the placenta in the prior art has the following defects: 1. It is usually taken orally, and the absorption and utilization rate is not high; 2. It contains estrogen, which increases the risk of tumors for the user; 3. The functional effect is single, only It has ordinary health care functions, cannot inhibit cancer mutations, and does not have the function of repairing DNA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Example: Taking synthetic huBPP as an example, the synthetic cleavage and purification process on Pioneer is briefly introduced.

[0012] (1) Instruments and reagents

[0013] Pioneer peptide synthesizer, argon gas, purity 99.99%, dimethylformamide (DMF), piperidine, HATU, diisopropylethylamine, methanol, TFA (trifluoroacetic acid), side bond protected amino acids required for synthesis, Resin Fmoc-PAL-PEG-PS.

[0014] Note: Fmoc-fluorenylmethyl oxycarbonyl (Fluoreny lmethyl oxycarbonyl); PEG-polyethylene glycol; PAL-peptide amide linker (peptide amide linker); PS-resin (polystyrene).

[0015] (2) Synthesis process

[0016] Prepare gas→flush pipeline→check pipeline→synthesis preparation (reagent loading, input sequence, etc.)→synthesis→synthesis end.

[0017] (3) Operating procedures

[0018] 1. Turn on the machine and adjust the air pressure, check for air leakage:

[0019] 1) Turn on the power switch, UPS switch, and computer in turn;

[0020] 2) Install all bot...

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PUM

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Abstract

The invention discloses a synthetic method for nutrient substances of organ peptides. The method comprises the following steps: coupling a protected amino group: coupling the first protected amino group on a solid phase carrier in the form of a covalent bond; carrying out deprotection: carrying out the deprotection on the amino group under the condition of keeping a side chain group stable, and exposing free amino groups; coupling: condensing the next activated amino acid with the former amino acid combined to the solid phase carrier, and forming peptide bonds; extending the peptide bonds: repeatedly carrying out the two steps of the deprotection and coupling to extend the peptide bonds to designed lengths; cutting: cutting synthesized peptides from the solid phase carrier and carrying out the deprotection of side chains, finally purifying and identifying the cut peptides. By adopting the synthetic method for the nutrient substances of the organ peptides, more than 3000 types of cellular activity factors and a variety of nutrient substances of FGF, AFGF, EFG, stem cell small molecules and the like are extracted from placentas. The organ peptides in the invention have uniqueness, can realize targeted localization and have the abilities of scavenging free radicals, resisting antioxidation, repairing DNA and regulating immunity.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a method for synthesizing organ peptide nutrients. Background technique [0002] Placenta is a commonly used health product, which is a general term for small molecular compounds with immune activity extracted from animal placenta. The theory of traditional Chinese medicine believes that the placenta is dry and salty, and it belongs to the lung and kidney meridian. Its function is to replenish qi, nourish blood, and benefit essence. Its effects mainly include the following points: it has health care effect on the skin, has a great impact on immunity and exercise ability, and has anti-fatigue, anti-aging and cellular immunity effects. Because the placenta has the above-mentioned many functions, it has become an important subject to extract and separate its active ingredients with modern bioengineering technology and modern chemical methods. The method of extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/08C07K1/06C07K1/04
CPCC07K1/04C07K1/06C07K1/08
Inventor 王浩
Owner SHANGHAI JIAOJIAREN MEDICAL COSMETOLOGY OUT PATIENT DEPT CO LTD
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