83 results about "Heavy ion beam" patented technology

A tape data carrier for protecting articles and documents from counterfeiting and copying is formed by a polymer structure including at least one polymer layer of which at least one layer has at least one of through-perforations and pits. These through-perforations and pits are preferably between 0.001 mum and 20 mum in size and can be filled with different materials. The data carriers can carry concealed and visible macro-and micro- images created by heavy-ion bombardment of the polymer film, subsequent exposure of the bombarded film to ultraviolet radiation, and etching of the polymer film in a solvent. A device for manufacturing a data carrier of this type includes the following elements configured in series: a heavy ion source; a heavy ion beam-formation system; an ion guide; a three-dimensional amplitude modulation unit; and a target which is destined to become the data carrier. The three-dimensional amplitude modulation unit is designed to hold a matrix of wafers and is connected to a drive for rotating and translating the wafers. The drive is connected via a control unit to the three-dimensional amplitude modulation unit for positioning the target.

The invention discloses a monitoring system and a monitoring method for SRAM type FPGA single particle functional interruption, and relates to the field of a single particle. The method comprises the steps of: A, setting a heavy ion beam flow with an initial LET value to irradiate a test board; B, judging whether a single particle functional interruption phenomenon happens to the test board, if so, recording that the single particle functional interruption phenomenon happens one time to the test board, and if not, considering that the single particle functional interruption phenomenon does not happen to the test board; C, judging whether the test board satisfies the following condition that the number of the single particle functional interruption phenomenon reaches a predetermined number or the total injection quantity of incident particles reaches a predetermined quantity, if so, performing a step D, and if not, performing the step B; D, judging whether a [sigma]-LET curve can be obtained by means of fitting, if so, obtaining the [sigma]-LET curve by means of fitting, and if not, adjusting the LET value of the heavy ion beam flow and performing the step B. The system and the method provided by the invention are capable of predicting the SEFI rate of an FPGA in various kinds of space environments.

The invention relates to the field of heavy ion beam (comprising proton beam) tumor treatment technology, in particular to a heavy ion beam current transverse dosage distribution measuring detector and a two-dimensional imaging method thereof. The detector is mainly characterized by comprising a gas sealing cavity (1) in which an ionization chamber inner core (2) is arranged and a multi-path signal transfer board (3) electrically connected with the ionization chamber inner core (2); the gas sealing cavity (1) consists of a main body framework (1-1), an entrance window (1-2) and an exit window (1-3); the ionization chamber inner core (2) consists of two groups of ionization chamber units, and each ionization chamber unit consists of a signal pole (2-1), an insulating cushion board (2-2) and a high-voltage pole (2-3); and one end of the multi-path signal transfer board (3) is provided with a contact end (3-3) which is inserted into a sealing port (1-5) of the gas sealing cavity (1) and connected with the signal pole (2-1) of the ionization chamber inner core (2), while the other end is provided with a multi-core connector (3-2) which is a signal output port of a beam current profile monitoring detector.

The present invention is a chemical synthesis process of quinolone, which relates to the field of veterinary drug feed additives. The existing synthesis technology is to select from various quinoxaline compound substituted derivatives, but these compounds have relatively large toxic and side effects, and simply change The side chain can no longer meet the needs. The present invention uses heavy ion beams to modify the structure of quinoxaline to produce new compound molecules. Through pharmacodynamic research, the standard sample is separated for chemical synthesis. The present invention designs three synthetic routes. Corresponding to the three chemical synthesis processes, the new compound was identified by spectrum, and it was determined to be quinolone. After further growth-promoting and toxicity tests, it showed obvious improvement and improvement compared with the lead compound quinolone. The invention has the beneficial effects of greatly shortening the development cycle and greatly saving the development cost, and shows that quinolone is a very vital veterinary drug feed additive.

The invention mainly relates to a method and a device for implanting non-full stripping heavy ion beams which are provided by a cyclotron and have mass numbers less than or equal to 40 into a synchrotron. The method comprises the following steps: 1. accelerating the heavy ion beams which are not fully stripped and have mass numbers less than or equal to 40 until the energy is 5.0-10.0MeV/u and the intensity of the heavy ion beams is 2.0-6.0mu A; 2. deflecting the heavy ion beams with mass numbers less than or equal to 40 in the step 1 to a stripping foil and embossing the central track of the synchrotron to the position of the stripping foil in the position of an implanting point; 3. reducing the embossment of the central track in the step 2, implanting the stripped heavy ion beams to fill in the space of the synchrotron and enabling the heavy ion beams to carry out cyclotron in the synchrotron. The invention also provides the device for implanting the heavy ion beams into the synchrotron. The device has the advantages of simple device, convenient operation and high implantation efficiency and can realize multiple choices of the charge states of the heavy ion beams by adjusting the thickness of the stripping foil.

The invention relates to the field of radioactive nuclear beam physics, heavy ion beam cancer treatment, heavy ion irradiation materials and heavy ion irradiation breeding. A position sensitive detector for higher energy heavy ion beam diagnosis is mainly characterized in that a beam probe is arranged in an air seal cavity, and the beam probe is fixedly connected to a fixing support of a port sealing flange assembly. The air seal cavity comprises an incidence window arranged on one side of an air box and an exitance window arranged on the other side of the air box. The beam probe is composed of two beam measuring units. Each beam measuring unit is composed of a high voltage pole, an insulating cushion plate and a signal pole which are sequentially arranged. The port sealing flange assembly is composed of the fixing support and a port sealing flange. A multichannel signal leading out pin board comprises a multichannel signal leading out board and a multichannel signal pin board. A contact end is arranged at one end of the multichannel signal pin board, inserted into a sealing opening of a sealing flange, and is connected with the signal output end of the multichannel signal leading out board. A multi-core connector is arranged at the other end of the multichannel signal pin board and serves as a signal output end opening of the beam position sensitive device. The signal input end of the multichannel signal leading out board is connected with the signal poles of the beam probe.

The invention relates to a device and a method for demarcating and calibrating a dose monitoring detector in heavy ion beam cancer treatment. The structure of the device is characterized in that a collimator, the dose monitoring detector, a mini ridge-shaped filter, a water tank and a standard ionization chamber are arranged on a beam flux axis in sequence. The standard ionization chamber is arranged inside the water tank. The depth position of an irradiation beam mini spread-out Bragg peak in water is obtained by measuring absorbed dose of the standard ionization chamber at different depth in aqueous medium. At the depth position, the dose monitoring detector is demarcated and calibrated by the standard ionization chamber so as to obtain demarcating and calibrating factors of the measurement of the dose monitoring detector for the mini spread-out Bragg peak cancer treatment beam with a Gauss arrangement. With the demarcating and calibrating factors, the entire process of three-dimensional conformal irradiation therapy with uniform physical absorption dose or uniform biological effective dose in a tumor target volume can be conveniently controlled, the requirements of the treatment of different clinical cases in practical clinical treatment are satisfied, and the treatment efficiency of a treatment device is improved.

The invention discloses a single particle latch monitoring method and apparatus of an FPGA. The method specifically comprises the following steps: using a heavy ion beam flow to irradiate the FPGA, monitoring the working current of the FPGA, and when the working current exceeds a specified value, performing reconfiguration on the FPGA; if the reconfiguration fails, performing power-off restarting on the FPGA, and reloading a program; and if program reloading succeeds, recording a single particle latch for once. By using the method provided by the invention, the working current of a device can be monitored in real time, the determination of an FPGA single partial latch is facilitated, at the same time, since a programmable power supply controlled by a computer is employed, a tested device can be protected.

The invention relates to an accelerator which combines a cyclotron and a synchrotron and is used for cancer therapy with protons-heavy ion beams, comprising an ion source E and the synchrotron C. The accelerator is characterized in that the synchrotron C comprises a septum magnet implanting device (5), a septum magnet extracting device (6), a radio-frequency accelerating device (9), eight bending sections of the synchrotron (1-1 to 1-8) and eight straight sections of the synchrotron (2-1 to 2-8), which are connected by an ion beam transmission line F; the ion beam implantation end of the synchrotron C is provided with a sector focusing cyclotron A or/and a separated sector focusing cyclotron B. By adopting the method of combining the cyclotron and the synchrotron, a set of accelerator devices required by cancer therapy with protons and heavy ion beams is set up to realize the requirements of clinical therapy on beam parameters; the mass numbers of the protons and the heavy ions are less than or equal to 40; the protons and heavy ion beams have wide energy range from 10MeV/u to 400MeV/u and high flux (the ion number provided by each pulse is up to 10<7-10> magnitude).

The invention relates to a device used in 3-D conformal radiotherapy to gross tumor volume with heavy ion beams, comprising a magnet scanning system, a beam monitor system, a mini-ridge filter, a range shifter, a multi-leaf collimator and a patient body surface compensator, which are sequentially arranged on the body surface of the patient. The centers of the components and the center of the gross tumor volume are located at the beam axis. The invention overcomes the defects that the conformality is low and the scatterer impairs beam quality in current 2-D conformal radiotherapy by heavy ion beams based on a passive beam flow distribution system, and adopts 3-D conformal irradiation without the scatterer needed in current 2-D conformal radiotherapy, thus improving conformality in the therapy to the gross tumor volume with heavy ion beams. The invention can protect the health organs around the gross tumor volume to the largest extent and reduce incidence of disease at the normal organs without reducing the rate of using large quantity of Bragg peak to efficiently kill the cells in the gross tumor volume, thus improving curative effect of the heavy ion beams.

The invention relates to an operation method for eliminating a hysteresis effect influence of a synchronous accelerator. The operation method is used for solving the problem that the position and intensity of heavy ion beams in the synchronous accelerator under different energy conditions are inconsistent because a magnet has a hysteresis effect. The operation method of an accelerator in a magnetic field major cycle mode mainly comprises the following steps of: 1, determining the maximal energy value of a beam of the synchronous accelerator required for a tumor cell therapy; 2, calculating a power operation curve of a dipolar magnet, a quadrupole magnet and a sectupole magnet for controlling a beam track by using magnetism measuring parameters; 3, uploading an operation curve data packet of the magnets to a remote database connected with a power supply controller; 4, analyzing the data packet by the remote database and issuing data to corresponding control front-ends; and 5, trigging data by using a trigger to output the data to the power source of the related power supply and control the track of the heavy ion beam.

The provision of a new method for analyzing organic molecules such as protein and endocrine disrupting chemicals with excellent sensitivity. A secondary ion mass spectrometry method using a heavy ion beam as a primary ion beam enables the detection of, for example, an organism-related material at the sub-amol level with high sensitivity. As a result, favorable imaging of an organism-related sample can be performed.

The present invention is heavy ion beam irradiation effect to obtain quinhydroxy ketone, and relates to heavy ion beam irradiation technology. Heavy ion beam irradiation process for developing new medicine is superior to available chemical synthesis process, which has long developing period, high cost and high manpower consumption, and can obtain new matter in short period and separate out lead compound with obvious medicine effect. The heavy ion beam irradiation process of obtaining quinhydroxy ketone is to irradiate quinalkenyl ketone with 16O8+ and 12C6+ heavy ions in the initial energy of 75 MeV/micron, and energy depositions of 1.585x10<2> Gy-1.585x10<12>Gy and 1.656x10 Gy-1.656x10<9>Gy. The irradiation product quinhydroxy ketone has strengthened antibacterial activity and lowered toxicity, and the present invention provides one effective way for developing new medicines.

The invention discloses a preparation method of a graphene nano-hole which is supported by a micropore, belonging to the fields of application of heavy ion beams and processing of films. A porous graphene composite material supported by the micropore is mainly characterized by comprising monolayer graphene, wherein the monolayer graphene is arranged on a polymer film; a nanoscale hole is formed in the graphene, overlapped and communicated with a cone-shaped hole of the polymer film. Through the preparation method, a graphene/polymer film composite structure is irradiated by using high-energy heavy ions; a hole with the diameter being several nanometers is formed in the graphene by using irradiation damage effect of the heavy ions; meanwhile, a columnar damage area is formed in the polymer film; then an irradiated area of a polymer is etched to form a cone-shaped nano-hole by using a chemical etching method; since the position of the graphene hole is overlapped and communicated with the position of the cone-shaped hole of the polymer, the graphene nano-hole which is supported by the micropore can be obtained. Due to the support effect of the polymer micropore, the graphene nano-hole is wide in application prospet in rectification of the ions, filtration and screening of the ions and detection of biological molecules.

The invention relates to a heavy ion production device for industrial production of nuclear track membrane. The heavy ion production device comprises an ion source, an LEBT beam line, a particle accelerator, an HEBT beam line and a membrane irradiation terminal; the ion source is used for generating a heavy ion beam in a high charge state and carrying out primary acceleration on the heavy ion beam; the LEBT beam line is used for analyzing the heavy ion beam and transmitting the heavy ion beam to the particle accelerator in a matching manner; the particle accelerator performs main accelerationon the heavy ion beam and then injects the heavy ion beam into the HEBT beam line; the HEBT beam line splits the injected heavy ion beam into a plurality of heavy ion beams and then transmits the heavy ion beams to a plurality of membrane irradiation terminals, and the membrane irradiation terminals lead out the heavy ion beams and irradiate a thin membrane placed in the atmospheric environment. Due to the fact that the thin membrane can be placed in the atmospheric environment to be irradiated, the thin membrane is convenient and rapid to replace, the thin membrane replacing time is greatly shortened, multiple terminals can irradiate the thin membrane at the same time, the irradiation efficiency of the thin membrane is greatly improved, and thus the production efficiency of the nuclear track membrane is improved.

The invention relates to a manufacturing method of a collimator. The problems that the shape of a pinhole of an existing pinhole collimator is not ideal, so that low-energy scattering of heavy ion microbeams is serious, heavy ion beam spots are large, and the application needs can not be met are solved. The manufacturing method of the pinhole collimator includes the following steps: 1) blade grinding, the top ends of cutting edges of blades are ground to be smooth and clean by using precision abrasive paper; 2) slit structure splicing, the cutting edges of the two blades are oppositely fixed on a bottom liner, and a slit is reserved between the cutting edges; 3) assembling, two slit structures are fixed together in an overlaying mode to form the pinhole of the pinhole collimator. The top ends of the cutting edges of the blades of the pinhole collimator manufactured according to the manufacturing method are good in straightness, the width of the spliced slit can be smaller than 1 micron, low-energy scattering ingredients of the heavy ion microbeams can be better lowered, the generated heavy ion beam spots are good in quality, and the application in heavy ion microbeam irradiation equipment is well achieved.

The invention relates to the accelerator beam flow diagnosis, beam flow measurement, and vertical beam bunch shape measurement field and especially relates to a proton heavy ion-beam-flow vertical beam bunch shape measurement detector. The detector comprises a detector main body and a microwave band shape line structure arranged on the detector main body. The detector main body comprises a flange. A tantalum copper composite board is connected to the flange through a support frame. A water cooling pipe is arranged between the flange and the tantalum copper composite board. The microwave band shape line structure is arranged on an inner side of the tantalum copper composite board. The microwave band shape line structure is fixed to a microwave band shape line bottom plate. Adaptors are arranged above and below the microwave band shape line structure respectively. The microwave band shape line structure comprises a medium substrate. Upper layer ground and lower layer ground are arranged above and below the medium substrate respectively. The medium substrate is provided with a positioning hole, a first metallization through hole and a second metallization through hole. A band shape line conduction band and a microstrip line conduction band are arranged on the medium substrate. The structure is compact, processing and operation control are easy to achieve, time resolution is high and anti-interference performance is high.

The invention relates to the field of technology of heavy-ion beam cancer therapy, in particular to a Bragg curve detector and a using method thereof. A Bragg curve detector for quick measurement in heavy-ion cancer therapy comprises an outer frame (1) and a plurality of unit ionization chambers (2), and is mainly characterized in that: water equivalent bodies (3) with different thicknesses are arranged in front of the unit ionization chambers (2); an incidence window (1-1) and an emergence window (1-5) are arranged at front and rear ends of the outer frame (1); a supporting plate (1-2) with a groove, a signal lead-out plate (1-3) and a high-voltage input plate (1-4) are arranged between the incidence window (1-1) and the emergence window (1-5); each unit ionization chamber (2) comprises a signal pole (2-1) which is connected with the signal lead-out plate (1-3) and a high-voltage plate (2-2) which is connected with the high-voltage input plate (1-4); and the unit ionization chambers (2) and the water equivalent bodies (3) in front are arranged inside the supporting plate (1-2) with the groove. The detector can realize Bragg curve measurement on incident particles in ms-order time.

The invention relates to a heavy ion beam irradiation breeding method of artemisia carvifolia. The method comprises the following steps: (1), planting high quality seeds from Yongzhou of Human in fields of Yuzhou of Henan, and screening and reserving seeds according to yield, disease resistance, cold resistance and artemisinin content; (2), performing irradiation induced mutation on artemisia carvifolia seeds obtained in the first step through heavy ion beam, so as to obtain irradiated seeds; meanwhile taking nonirradiated artemisia carvifolia seeds obtained in the first step as a comparison;(3), plating the irradiated seeds to the fields, so as to form a first-generation group; meanwhile taking the nonirradiated artemisia carvifolia seeds as a comparison to select variant individual plants, and determining an optimal irradiation dosage; (4), selecting beneficial mutation types, and screening excellent variant strains; (5), performing identification test on the yield, quality and resistance of the excellent variant strains, observing and detecting hereditary stability an SRAP molecular marker, performing provincial region production testing and quality detection on stable strains,then performing variety technical evaluation, and declaring new varieties. The method effectively improves the breeding efficiency.

The invention belongs to the technical field of irradiation measurement, and particularly relates to an irradiation on-line internal friction in-situ measurement device. The device comprises a sealed vacuum chamber (1) provided with a heavy ion beam pipeline (9), the interior of the vacuum chamber (1) is used for arranging an irradiation sample (12) and can heat the irradiation sample (12), an accelerated heavy ion beam can irradiate the interior of the irradiation sample (12) through the heavy ion beam pipeline (9), and the device further comprises a displacement detector (7) used for measuring the displacement change of the irradiation sample (12). The device realizes on-line in-situ measurement of the mechanical property of the material in a heavy ion irradiation experiment in a high-temperature environment, can visually obtain the change of the mechanical property of the material by measuring an internal friction spectrum in the irradiation process, and obtains the type, concentration and dynamic diffusion process of irradiation defects generated in the material irradiation process, and information of irradiation embrittlement, defect evolution and the like of the material under irradiation conditions such as temperature, irradiation dose and the like is obtained.

The invention discloses a method for mutagenizing soybeans through heavy ion beam C irradiation, relates to a soybean breeding method, and aims to solve the technical problems of low mutation rate andfavorable mutation rate of an existing heavy ion beam irradiation method. The method comprises the following steps of 1, irradiating soybean seed hilum by adopting heavy ion beam carbon ions to obtain current-generation M0 seeds; 2, irradiating the current-generation M0 seeds by adopting the heavy ion beam carbon ions, and performing sowing to obtain a generation M1; 3, in spring of the second year, planting all M1-generation single plants in plant rows, harvesting, numbering and storing all variant single plants, and performing seed testing indoors; 4, in winter of the same year, performingharvesting, numbering and seed testing on strain single plants which are continuously separated from a generation M3; and 5, in spring of the third year, planting the single plants harvested from theM3 to obtain a generation M4, and selecting out a strain with excellent characters and stable inheritance to complete the process. According to the method, the mutation rate can be increased, offspring mutation materials are rich, multiple beneficial types are achieved, and excellent mutation characters such as high protein, lodging resistance, high yield and large grains can be screened out.

The invention belongs to the technical field of agriculture, relates to a sweet sorghum breeding method, in particular to a method for breeding sweet sorghum by using a heavy ionmutation breedingtechnique. The sweet sorghum breeding method is mainly characterized by comprising the following steps: (1) performing heavy ion beam radiation, namely, providing carbon, oxygen or argon heavy ion beams by using a heavy ion accelerator, and performing radiation treatment on sweet sorghum seeds at a vertical radiation terminal for 4-6 minutes under the conditions that the energy is 80-100MeV/mu, the radiation dosage is 80-120Gy and the dosage rate is 20-30Gy/minute; (2) performing mutant screening; (3) performing mutant detection; (4) performing hybridized combination optimization. Due to the adoption of the breeding method provided by the invention, after heavy ion radiation, mutant planting resources which are good in precocity property, high in sweet, high in yield and resistant to adversity can be obtained, after being planted for M3-M4 generations, the mutants can be stabilized, and the efficiency of mutant screening, mutant detection and hybridized combination blending is increased by more than 10% when being compared with that of a single crossbreeding method.

The invention discloses application of a PCBP1 gene in preparing a radiotherapy sensitivity enhancing kit, and in particular relates to application of the PCBP1 gene in preparing a sensitivity enhancing kit for tumor radiotherapy utilizing ionizing radiation including heavy ion rays. The nucleotide sequence of the PCBP1 gene is as shown in SEQ ID NO.1 and the PCBP1 gene is established in eukaryotic expression plasmid. Together with heavy ion beams, the PCBP1 gene regulates and controls expression of the CD44v6 gene related to tumor metastasis and invasion, inhibits proliferation, migration and invasion of HeLa tumor cells, remarkably down-regulates the cell cycle regulatory protein Cyclin D1, prompts cells to generate G0/G1 retardation, enhances the radiotherapy sensitivity of HeLa cells, up-regulates pro-apoptotic protein Tap73 and expression of the mitochondria apoptosis pathway MCL, down-regulates the apoptosis inhibition DelNp73 protein, and induces apoptosis of many HeLa cells.

The present invention discloses a chemical synthesis process of hydroxy quinocetone. In the existing synthesis technology, the substituted derivatives of a variety of quinoxaline compounds are selected, but the compounds have high toxic-side effects, and the requirements cannot be met by simply changing the side chains. According to the present invention, heavy ion beam is used to transform the structure of quinoxaline to generate the new compound molecule, and with the pharmacodynamic research, the standard sample is separated and chemical synthesis is performed; three synthesis routes are designed and are corresponding to three chemical synthesis processes, the new compound is subjected to spectroscopy identification, the new compound is determined as hydroxy quinocetone, and the further growth promoting and toxicity test results show that the hydroxy quinocetone provides significant improvement compared with the lead compound quinocetone; and the process has beneficial effects of substantially-shortened research period and substantially-saved research cost, and the research results show that the hydroxy quinocetone is the extremely viable veterinary feed additive.