Holding structure and detector including holding structure

Abstract

A holding structure for holding a sample detection orifice plate. The orifice plate is equipped with electrodes and accommodates samples. The holding structure includes a holder and a pressure conversion plate. The holder includes a holder body having an accommodating portion for receiving the orifice plate; and at least one probe module disposed at the bottom of the accommodating portion. The probe module includes a plurality of contact probes, one end of which includes elastic contacts that translate perpendicularly to the bottom of the accommodating part and the other end is electrically connected to the holder control circuit; at least one switch probe, one end of which includes elastic contacts that are perpendicular to the bottom of the accommodating part. The bottom of the elastic pressing part is translated and the other end is electrically connected to the holder control circuit; and the electrical insulating plate, the contact probe and the switch probe are penetrated on the electrical insulating plate. When the orifice plate is received in the accommodating part, the bottom of the orifice plate presses against the elastic contact of the contact probe and the elastic pressing part of the switch probe, and the elastic contact is electrically connected to the electrode provided on the bottom of the orifice plate, And the orifice plate is located between the pressure conversion plate and the bottom of the accommodating part.

Description

technical field [0001] The invention relates to a holding structure for holding a sample detection hole plate, and to a detector comprising the holding structure. Background technique [0002] In the field of sample detection, especially in the field of liquid biopsy detection, an orifice plate with multiple holes is usually used to contain biological samples. The electrodes of the orifice plate are electrically connected to the bottom of the holes, so that the weak current signal of the biological sample It can be output to the signal detection processing unit outside the orifice plate through the electrodes. In addition, because the concentration of the captured target molecule is very low, the current signal that can be detected is also very weak, usually on the order of nanoampere or picoampere. However, in the currently existing detection equipment, it is generally only possible to detect the milliamp level. Therefore, a holding structure is needed, which can repeated...

AI Technical Summary

Problems solved by technology

In addition, because the concentration of the captured target molecule is very low, the current signal that can be detected is also very weak, usually on the order of nanoampere or picoampere

However, in the existing detection equipment, generally only the detection of milliampere level can be achieved.

Images