Application of cinnamaldehyde in the preparation of drugs for targeted treatment of bacterial infections
A technology for bacterial infection and targeted therapy, applied in the field of medicine, can solve problems such as untimely treatment, difficult clinical treatment of infectious diseases, and increased mortality.
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Embodiment 1
[0035] Example 1 is cinnamaldehyde 1.25, Tween-80 0.05g.
[0036]1. Methods: 30 strains of non-repeated multidrug-resistant bacteria isolated from inpatients in the Second Hospital of Hebei Medical University were selected, including methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Acinetobacter baumannii (CR-ABA), carbapenem-resistant Klebsiella pneumoniae (CRE), carbapenem-resistant Pseudomonas aeruginosa (CR-PAE), vancomycin-resistant Enterococcus (VRE). At the same time, 28 strains of each of the above five non-multidrug-resistant Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterococcus faecium were selected to compare the effects of cinnamic aldehyde on the above bacteria. Effect.
[0037] Quality control strains: ATCC25922, ATCC25923, ATCC29212, ATCC27853.
[0038] 2. Results:
[0039] The results show that cinnamaldehyde has good sensitivity to multi-drug resistant bacteria, see Table 1
...
Embodiment 2
[0045] Embodiment 2 cinnamic aldehyde monomer clathrate of the present invention
[0046] Composition: Cinnamaldehyde 1.25g (50 parts by weight)
[0047] 2-hydroxypropyl-β-cyclodextrin 1.25g (50 parts by weight)
[0048] Preparation:
[0049] 1) Add 2-hydroxypropyl-β-cyclodextrin to 80°C deionized distilled water, stir to dissolve, then cool down to 20°C to prepare an aqueous solution for use; among them, 2-hydroxypropyl-β-cyclodextrin The weight mg / volume mL ratio of essence and deionized distilled water is 1:10;
[0050] 2) Under stirring, slowly add cinnamon aldehyde dissolved in ethyl acetate dropwise to the aqueous solution obtained in step 1). After the dropwise addition, raise the temperature to 70°C and continue stirring for 1 hour, then refrigerate for 24 hours to obtain a refrigerated solution , standby; wherein, the volume mL ratio of cinnamaldehyde to ethyl acetate is 1:6;
[0051] 3) Filter the refrigerated liquid obtained in step 2), wash the solid matter wit...
Embodiment 3
[0051] 3) Filter the refrigerated liquid obtained in step 2), wash the solid matter with a small amount of distilled water, dry it in vacuum at a low temperature of 5°C for 24 hours, grind it, sieve it through 80 mesh, wash it with ethyl acetate three times, and dry it in the air to obtain white Loose cinnamaldehyde monomer inclusion compound. Embodiment 3 cinnamic aldehyde monomer clathrate of the present invention
[0052] Composition: Cinnamaldehyde 1g (10 parts by weight)
[0053] 2-hydroxypropyl-β-cyclodextrin 2g (20 parts by weight)
[0054] Preparation method: with embodiment 2.
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