Lipid-lowering drug comprising wild chrysanthemum extract and preparation method of wild chrysanthemum extract

The technology of wild chrysanthemum flower extract and blood lipid-lowering drug is applied in the field of preparation of wild chrysanthemum flower extract, which can solve the problems of low biological activity and poor agonistic activity, and achieve the effect of good development prospect and good blood lipid-lowering effect.

Inactive Publication Date: 2017-01-25
广州市爱菩新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims at the problem that existing LXR agonists cannot enter into clinical trials due to their poor activating activity and low biological activity, and the attempts of LXR agonists to treat hyperlipidemia have not been successful. A blood-lipid-lowering drug whose activity is better than LXR agonist GW395, and a preparation method of the active ingredient wild chrysanthemum extract in the blood-lipid-lowering drug

Method used

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  • Lipid-lowering drug comprising wild chrysanthemum extract and preparation method of wild chrysanthemum extract
  • Lipid-lowering drug comprising wild chrysanthemum extract and preparation method of wild chrysanthemum extract
  • Lipid-lowering drug comprising wild chrysanthemum extract and preparation method of wild chrysanthemum extract

Examples

Experimental program
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Effect test

Embodiment 1

[0041] This example provides a preparation method of the wild chrysanthemum extract and the analysis of the physiological activities of compounds 1-4 in the wild chrysanthemum extract.

[0042] The preparation method of wild chrysanthemum extract comprises the following steps:

[0043] (1) extraction

[0044] Weigh 7.0Kg of dried wild chrysanthemum, soak the dried wild chrysanthemum with 10L of ethanol (95%) at normal temperature and pressure for 24h, then filter, and collect the filtrate. Repeat the extraction of Flos Chrysanthemum for three times, combine the filtrates extracted three times, and then place the filtrate in a water bath to concentrate under normal pressure to obtain 2.0Kg of extract.

[0045] (2) Extraction

[0046] Put the extract extract into 5L of water, stir to make the extract extract become a turbid suspension, then extract with ethyl acetate to obtain an extract, concentrate the extract to obtain a concentrate, and dry the concentrate to obtain 425g o...

Embodiment 2

[0134] This embodiment provides a blood lipid-lowering drug containing the wild chrysanthemum extract, which contains the wild chrysanthemum extract and / or pharmaceutically acceptable carrier described in Example 1, and the active ingredient is twice as much as that contained in the wild chrysanthemum extract. Semiterpenoids, namely Compound 1, Compound 2, Compound 3 and Compound 4 described in Example 1.

[0135] From the test results in Example 1, it can be seen that the blood lipid-lowering drug containing the wild chrysanthemum extract of this embodiment has the effect of reducing the accumulation of oil droplets and triglycerides in the differentiation process of 3T3-L1 preadipocytes, so it has a good blood lipid-lowering effect. Effect, there is a good development prospect in the treatment of hyperlipidemia.

Embodiment 3

[0137] This example provides a blood lipid-lowering drug containing the extract of Chrysanthemum chrysanthemum, which contains Compound 1 described in Example 1 and / or a pharmaceutically acceptable carrier, and the active ingredient is Compound 1.

[0138] From the test results in Example 1, it can be seen that the blood lipid-lowering drug containing the wild chrysanthemum extract of this embodiment has the effect of reducing the accumulation of oil droplets and triglycerides in the differentiation process of 3T3-L1 preadipocytes, so it has a good blood lipid-lowering effect. Effect, there is a good development prospect in the treatment of hyperlipidemia.

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Abstract

The invention relates to the technical field of lipid-lowering drugs, and specifically relates to a lipid-lowering drug comprising a wild chrysanthemum extract and a preparation method of the wild chrysanthemum extract. The wild chrysanthemum extract in the lipid-lowering drug comprises a sesquiterpenoids compound disclosed by the invention, wherein the sesquiterpenoids compound remarkably inhibits the accumulation of triglyceride and total fat in the differentiation process of preadipocyte 3T3-L1, the inhibiting effect is better than that of berberine, a positive control compound; liver X receptors alpha and beta (LXRalpha and LXRbeta) are also remarkably excited, the exciting effect is better than that of an LXR agonist tool molecule GW3965, and particularly, the exciting effect of a compound 4 is remarkably better than that of GW3965. In addition, the sesquiterpenoids compound further regulates the mRNA expression quantity of transcription factors SREBP-1c, PPARgama and CEBPdelta which are of vital importance for cholesterol metabolism. Therefore, the disclosed lipid-lowering drug comprising the wild chrysanthemum extract has an excellent effect of lowering lipid, and has an excellent development prospect on the treatment of hyperlipidaemia.

Description

technical field [0001] The invention relates to the technical field of blood lipid-lowering drugs, in particular to a blood fat-lowering drug containing wild chrysanthemum extract and a preparation method of wild chrysanthemum extract. Background technique [0002] Hyperlipidemia can induce atherosclerosis, hypertension, diabetes, coronary heart disease or other cardiovascular and cerebrovascular diseases. The successful development of high-efficiency, low-toxicity, and economically reasonable lipid-lowering drugs can reduce the incidence of a group of diseases and the resulting mortality, such as atherosclerosis, hypertension, diabetes, and coronary heart disease. Therefore, the research and development of blood lipid-lowering drugs is a key scientific and technological problem that needs to be solved urgently in the social development of our country, and has great social benefits. [0003] Cholesterol level is one of the important indicators to measure hyperlipidemia. Liv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/287A61P3/06
Inventor 徐峻李婵娟顾琼
Owner 广州市爱菩新医药科技有限公司
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