Preparation method of aldehyde-containing phosphorylcholine polymer and dopamine cross-linked coating

A technology of phosphorylcholine and polymers, which is applied in the field of preparation of phosphorylcholine polymers and dopamine cross-linked coatings, can solve the problems of limited application range, harsh conditions in the synthesis process, and difficulty in preservation, and achieve wide application The effect of prospect, simple preparation method and convenient operation

Inactive Publication Date: 2017-02-08
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the crosslinkable group of the polymer is easy to hydrolyze and crosslink during the synthesis process, which

Method used

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  • Preparation method of aldehyde-containing phosphorylcholine polymer and dopamine cross-linked coating
  • Preparation method of aldehyde-containing phosphorylcholine polymer and dopamine cross-linked coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of the phosphorylcholine polymer containing aldehyde group and dopamine cross-linked coating of the present embodiment comprises the following steps:

[0027] Step 1. Weigh 16mmol 2-methacryloyloxyethylphosphorylcholine and 4mmol methacrolein, use 0.1mmol azobisisobutyronitrile as the initiator, and mix methanol and tetrahydrofuran at a volume ratio of 4:1 The mixed solvent was used as the reaction solvent. Under the protection of nitrogen, the polymerization reaction was carried out at 70°C for 24 hours. After the reaction was completed, it was dialyzed with a dialysis bag with a molecular weight cut-off of 7000, and then freeze-dried at -50°C to obtain the aldehyde group-containing phosphorylcholine polymer thing;

[0028] Step 2, dissolving dopamine and the phosphorylcholine polymer containing aldehyde group described in step 1 in methanol to obtain a mixed solution, the concentration of dopamine in the mixed solution is 0.25mg / mL, and the phos...

Embodiment 2

[0034] The preparation method of the phosphorylcholine polymer containing aldehyde group and dopamine cross-linked coating of the present embodiment comprises the following steps:

[0035] Step 1. Weigh 14mmol 2-methacryloyloxyethylphosphorylcholine and 6mmol methacrolein, use 0.1mmol azobisisobutyronitrile as the initiator, mix methanol and tetrahydrofuran according to the volume ratio of 5:1 The mixed solvent was used as the reaction solvent. Under the protection of nitrogen, the polymerization reaction was carried out at 70°C for 24 hours. After the reaction was completed, it was dialyzed, and then freeze-dried at -50°C to obtain an aldehyde group-containing phosphorylcholine polymer;

[0036] Step 2, dissolving dopamine and the phosphorylcholine polymer containing aldehyde group described in step 1 in methanol to obtain a mixed solution, the concentration of dopamine in the mixed solution is 0.5mg / mL, and the phosphorylcholine polymer containing aldehyde group The concentr...

Embodiment 3

[0040] The preparation method of the phosphorylcholine polymer containing aldehyde group and dopamine cross-linked coating of the present embodiment comprises the following steps:

[0041] Step 1. Weigh 19mmol 2-methacryloyloxyethylphosphorylcholine and 1mmol methacrolein, use 0.1mmol azobisisobutyronitrile as the initiator, mix methanol and tetrahydrofuran according to the volume ratio of 3:1 The mixed solvent was used as the reaction solvent. Under the protection of nitrogen, the polymerization reaction was carried out at 70°C for 24 hours. After the reaction was completed, it was dialyzed, and then freeze-dried at -50°C to obtain an aldehyde group-containing phosphorylcholine polymer;

[0042] Step 2, dissolving dopamine and the phosphorylcholine polymer containing aldehyde group described in step 1 in methanol to obtain a mixed solution, the concentration of dopamine in the mixed solution is 0.4mg / mL, and the phosphorylcholine polymer containing aldehyde group The concentr...

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Abstract

The invention discloses a preparation method of an aldehyde-containing phosphorylcholine polymer and dopamine cross-linked coating. The method comprises the steps of 1, preparing an aldehyde-containing phosphorylcholine polymer; 2, dissolving the dopamine and the aldehyde-containing phosphorylcholine polymer in a polar solvent to obtain a mixed solution, coating the mixed solution onto the surface of a to-be-modified material, and drying the to-be-modified material; 3, placing the dried to-be-modified material in an alkaline aqueous solution, and heating the material at 40 DEG C to 90 DEC C for 2-12 hours to obtain a cross-linked adhesive bionic coating of a cell outer membrane-simulated structure. The preparation method is simple and convenient in operation, which provides a novel approach for preparing a stable surface with the cross-linked adhesive bionic coating of the cell outer membrane-simulated structure. The prepared coating has a wide application prospect in the fields of blood purification, in-vivo implantation materials, tissue engineering, drug sustained release, biological sensors and the like.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a preparation method of a phosphorylcholine polymer containing aldehyde group and dopamine cross-linked coating. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers 2010, 79:724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino group on the chitosan molecule helps to adsorb various toxins in the blood, and can be used as a hemoperfusion material (Chemical Journal of Chinese Universities, 2002, 23:75-77; Journal of Microencapsulation 1993, 10:475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as hemodialysis material (Journal of Applied Polym...

Claims

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Application Information

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IPC IPC(8): C09D143/02C09D7/12C08J3/24C08J7/04C08F230/02C08F216/34B01D15/08A61L27/34A61L27/54A61L31/10A61L31/16C08L5/08C08L43/02
CPCA61L27/34A61L27/54A61L31/10A61L31/16B01D15/08C09D143/02C08F230/02C08J3/246C08K5/17C08J2305/08C08J2443/02C08J7/0427C08F216/34C08L43/02
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH
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