Theobromine or its derivatives for use in the treatment or prevention of nephrolithiasis
A technology for kidney stones and uses, applied in the field of uric acid crystal inhibitors, can solve problems such as the absence of known clinical studies
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[0031] A turbidimeter was used to obtain kinetic curves on the crystallization of uric acid corresponding to a 400 mg / l uric acid solution in synthetic urine (similar to the average composition of urine) at different pH and theobromine concentrations. figure 1 Kinetic curves are shown for uric acid (without theobromine) at pH=4.67 and for the same uric acid concentration with 10 mg / l, 20 mg / l and 40 mg / l added theobromine. As can be seen, the induction time (time when crystals start to appear) increases significantly with increasing theobromine concentration, indicating that this substance acts as a uric acid nucleation inhibitor.
[0032] The induction times were thus calculated for 400 mg / l uric acid in synthetic urine at different pH and different theobromine concentrations (Table 2). as by figure 2 As can be seen from the curves in , the induction time increases with increasing theobromine concentration. Additionally, the inhibitory effect was much more pronounced for i...
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