Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Theobromine or its derivatives for use in the treatment or prevention of nephrolithiasis

A technology for kidney stones and uses, applied in the field of uric acid crystal inhibitors, can solve problems such as the absence of known clinical studies

Active Publication Date: 2020-03-27
UNIV DE LAS ISLAS BALEARES
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although some in vitro studies of potential uric acid crystallization inhibitors have been performed, which have shown that saponins, glycosaminoglycans and glycoproteins display a surprising ability to inhibit uric acid crystallization, there are no known clinical studies on this subject. Research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Theobromine or its derivatives for use in the treatment or prevention of nephrolithiasis
  • Theobromine or its derivatives for use in the treatment or prevention of nephrolithiasis
  • Theobromine or its derivatives for use in the treatment or prevention of nephrolithiasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] A turbidimeter was used to obtain kinetic curves on the crystallization of uric acid corresponding to a 400 mg / l uric acid solution in synthetic urine (similar to the average composition of urine) at different pH and theobromine concentrations. figure 1 Kinetic curves are shown for uric acid (without theobromine) at pH=4.67 and for the same uric acid concentration with 10 mg / l, 20 mg / l and 40 mg / l added theobromine. As can be seen, the induction time (time when crystals start to appear) increases significantly with increasing theobromine concentration, indicating that this substance acts as a uric acid nucleation inhibitor.

[0032] The induction times were thus calculated for 400 mg / l uric acid in synthetic urine at different pH and different theobromine concentrations (Table 2). as by figure 2 As can be seen from the curves in , the induction time increases with increasing theobromine concentration. Additionally, the inhibitory effect was much more pronounced for i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the use of theobromine or derivatives thereof as inhibitors of uric acid crystals in order to prevent uric acid crystal formation in urine and thus prevent nephrolithiasis or in particular uric acid nephrolithiasis.

Description

technical field [0001] The present invention relates to the use of theobromine or derivatives thereof as inhibitors of uric acid crystals to avoid the formation of uric acid crystals in urine and thus avoid uric acid nephrolithiasis. Background technique [0002] It is currently known that the fundamental problem of uric acid nephrolithiasis lies in the more or less persistent existence of a urine pH value below 5.5. Urinary supersaturation with uric acid linked to excretion of this substance is important, but there are few cases where it has been shown to be a determinant in the development of urolithiasis. Intuitively, it seems likely that the presence of uric acid crystallization inhibitors must be relevant, since among individuals with the same urine pH and uric acid concentration, some individuals form uric acid nephrolithiasis and others do not. However, although some in vitro studies of potential uric acid crystallization inhibitors have been performed, which have sh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/522A61P13/12A61P13/04
CPCA61K31/522A61P13/04A61P13/12A61P19/06A23L33/10A23V2002/00A23V2200/30
Inventor F·格拉塞斯弗雷瑟达斯A·科斯塔巴乌萨R·M·普列托阿尔米拉利A·罗德里格斯罗德里格斯
Owner UNIV DE LAS ISLAS BALEARES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com