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Oral potassium chloride sustained-release tablet and preparation method thereof

A technology of potassium chloride sustained-release tablets and potassium chloride, which is applied to the active ingredients of alkali/alkaline earth metal chlorides, pharmaceutical formulations, metabolic diseases, etc., and can solve the problem of inability to achieve effective and stable slow-release of potassium chloride and high requirements for process conditions , complex process steps, etc., to avoid sudden release or rapid local drug release, avoid easy damage, and achieve stable and sustained release effects

Active Publication Date: 2021-05-25
BRIGHT FUTURE PHARMA LAB LTD (CN) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The purpose of the present invention is to overcome the above-mentioned defects in the prior art, and provide a kind of oral potassium chloride sustained-release tablet, aiming at solving the problem that the existing potassium chloride sustained-release tablet has potential safety hazards due to side effects and cannot realize effective and stable sustained release of potassium chloride. technical problem
[0019] Another object of the present invention is to overcome the above-mentioned prior art defect, provide a kind of preparation method of oral potassium chloride sustained-release tablet of the present invention, aim to solve existing process step complicated process of existing potassium chloride sustained-release tablet preparation method, to process Demanding conditions leading to technical issues that limit yields

Method used

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  • Oral potassium chloride sustained-release tablet and preparation method thereof
  • Oral potassium chloride sustained-release tablet and preparation method thereof
  • Oral potassium chloride sustained-release tablet and preparation method thereof

Examples

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preparation example Construction

[0050] Based on the oral potassium chloride sustained-release tablet described above, the embodiment of the present invention also provides a preparation method of the above oral potassium chloride sustained-release tablet. The preparation method of oral potassium chloride sustained-release tablet comprises the steps:

[0051] S01: compressing the potassium chloride tablet core material containing an effective dose into the tablet core after wet granulation;

[0052] S02: coating the tablet core with a coating solution to form the coating on the surface of the tablet core.

[0053] Specifically, the potassium chloride tablet core material in the above step S01 can be potassium chloride and the above-mentioned auxiliary materials added to the solvent to prepare the tablet core slurry. In one embodiment, the particle size of the potassium chloride dry particles is Preferably but not only 20 to 40 mesh, more preferably 25 to 30 mesh.

[0054] The solvent used for wet granulatio...

Embodiment 1

[0061] An oral potassium chloride sustained-release tablet and a preparation method thereof. Wherein, the oral potassium chloride sustained-release tablet comprises a potassium chloride tablet core and a sustained-release coating coated on the surface of the tablet core.

[0062] Among them, the potassium chloride tablet core includes potassium chloride, polyvinylpyrrolidone, and microcrystalline cellulose magnesium stearate in a weight ratio of 85.7:5.0:7.8:1.5, specifically as shown in the following table 11; the slow-release coating includes Amino methacrylate copolymer type A, ethyl cellulose, polyethylene glycol, and talc in a weight ratio of 90:10:10:5, as shown in Table 12 below.

[0063] The preparation method of present embodiment 1 oral potassium chloride slow-release tablet is as follows:

[0064] Preparation of potassium chloride tablet core:

[0065] Polyvinylpyrrolidone K90 was dissolved in ethanol, and potassium chloride crystal powder and microcrystalline cellu...

Embodiment 2

[0077] An oral potassium chloride sustained-release tablet and a preparation method thereof. Wherein, the oral potassium chloride sustained-release tablet comprises a potassium chloride tablet core and a sustained-release coating coated on the surface of the tablet core. Among them, the components contained in the potassium chloride tablet core are shown in Table 21 below, and the components contained in the sustained-release coating are shown in Table 22 below.

[0078] The preparation method of present embodiment 2 oral potassium chloride sustained-release tablets is as follows:

[0079] Preparation of sustained-release coating: refer to the preparation method of potassium chloride tablet core in Example 1.

[0080] Table 21

[0081]

[0082] Preparation of the sustained-release coating: refer to the preparation method of the sustained-release coating in Example 1.

[0083] Table 22

[0084]

[0085] The oral potassium chloride sustained-release tablets with a coat...

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Abstract

The invention discloses an oral potassium chloride sustained-release tablet and a preparation method thereof. An oral potassium chloride sustained-release tablet of the present invention comprises a tablet core containing an effective dose of potassium chloride and a coating coated on the tablet core, and is characterized in that: the coating is a sustained-release coating, which includes weight A mixture of aminomethacrylate copolymer type A and ethylcellulose in a ratio of (1-9):1. The preparation method includes the following steps: wet granulation of the potassium chloride tablet core material containing an effective dose, and then compressing into the tablet core, coating the tablet core with a coating liquid, and forming the tablet core on the surface of the tablet core. Coating step. In the embodiment of the present invention, the oral potassium chloride sustained-release tablet coating releases potassium chloride by means of membrane diffusion, so as to achieve stable sustained release of potassium chloride, without causing potential safety hazards to patients, and the preparation method is simple in process, and the process conditions It is easy to control, so that the prepared oral potassium chloride sustained-release tablet of the present invention has a high qualification rate and yield.

Description

technical field [0001] The invention belongs to the field of drug controlled-release preparations, and in particular relates to an oral potassium chloride sustained-release tablet and a preparation method thereof. Background technique [0002] Oral diuretics cause patients to lose potassium and sodium from the body. Diuretics may not cause any problems if taken short-term, but may cause potassium loss if taken long-term for high blood pressure. In some cases patients developed edema. Some patients showed substantial potassium depletion, but some patients were asymptomatic. There is evidence that potassium depletion is more likely in patients treated with diuretics and the mineralocorticoid active carbenoxolic acid. [0003] From the above, it can be seen that many treatment methods or procedures can lead to potassium depletion, that is, hypokalemia. Potassium depletion can be accompanied by defects in carbohydrate tolerance and glycogen deposition. In addition, antidiur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K33/14A61P3/12A61K9/22
Inventor 刘华吴涛汤明辉李海华张志燕
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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