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Application of peiminine for preparing drug for improving sensitivity of tumor cells to chemotherapy drugs

A technology of tumor cells and peiminin B, which is applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulations to achieve the effect of improving sensitivity

Inactive Publication Date: 2017-03-08
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the large dosage of some drugs, the toxicity to the body will also increase, so it is of great significance to find chemotherapy sensitizers with low toxicity and less adverse reactions to improve the therapeutic effect of chemotherapy.

Method used

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  • Application of peiminine for preparing drug for improving sensitivity of tumor cells to chemotherapy drugs
  • Application of peiminine for preparing drug for improving sensitivity of tumor cells to chemotherapy drugs
  • Application of peiminine for preparing drug for improving sensitivity of tumor cells to chemotherapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: The application of the peiminin B as a drug for improving the sensitivity of tumor cells to chemotherapy drugs, and the tumor cells are esophageal cancer cells or / and liver cancer cells or / and breast cancer cells or / and cervical cancer cells or / and lung cancer cells.

Embodiment 2

[0031] Example 2: As an optimization of Example 1, the esophageal cancer cells are esophageal cancer Eca109 cells.

Embodiment 3

[0032] Example 3: As an optimization of Example 1, the liver cancer cells are liver cancer HepG2 cells.

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PUM

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Abstract

The invention relates to the technical field of application of peiminine, and discloses application of peiminine for preparing a drug for improving sensitivity of tumor cells to chemotherapy drugs. The invention proposes the application of the peiminine for preparing the drug for improving the sensitivity of esophagus cancer cells, liver cancer cells, breast cancer cells, cervical carcinoma cells and lung cancer cells to chemotherapy drugs for the first time, and combination of the peiminine and the chemotherapy drugs can improve the sensitivity of the tumor cells to the chemotherapy drugs, and can obviously inhibit proliferation of the esophagus cancer cells, liver cancer cells, breast cancer cells, cervical carcinoma cells and lung cancer cells, thereby providing a new means for improving the therapeutic effects on esophagus cancer, liver cancer, breast cancer, cervical carcinoma and lung cancer.

Description

technical field [0001] The invention relates to the technical field of application of peiminin B, and relates to the application of peiminin B as a medicine for improving the sensitivity of tumor cells to chemotherapeutic drugs. Background technique [0002] Malignant tumor is one of the major diseases that endanger human health. For the treatment of malignant tumors, a combination of surgery, radiotherapy, and chemotherapy is the main method of comprehensive treatment. Clinically, the current drugs for treating tumors are mainly chemical drugs. However, due to the high toxicity of chemical drugs, they can also kill the body's own immune cells while killing tumor cells. The adverse reactions of patients are large, and there are great limitations in clinical use. . [0003] Chemosensitizer refers to a drug that can significantly improve the effect of chemotherapy by using a small dose of this substance in combination with chemotherapy drugs. Such drugs have no obvious anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P35/00
CPCA61K31/4375
Inventor 顾政一唐倩倩王云飞张裴聂勇战于军张论理
Owner XINJIANG INST OF MATERIA MEDICA
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